KEFX_HAEIN
ID KEFX_HAEIN Reviewed; 618 AA.
AC P44933;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Glutathione-regulated potassium-efflux system protein;
DE AltName: Full=K(+)/H(+) antiporter;
GN Name=kefBC; OrderedLocusNames=HI_0911;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Transport system that facilitate potassium-efflux, possibly
CC by potassium-proton antiport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L42023; AAC22568.1; -; Genomic_DNA.
DR PIR; A64102; A64102.
DR RefSeq; NP_439071.1; NC_000907.1.
DR RefSeq; WP_010869086.1; NC_000907.1.
DR AlphaFoldDB; P44933; -.
DR SMR; P44933; -.
DR STRING; 71421.HI_0911; -.
DR DNASU; 950431; -.
DR EnsemblBacteria; AAC22568; AAC22568; HI_0911.
DR KEGG; hin:HI_0911; -.
DR PATRIC; fig|71421.8.peg.952; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG1226; Bacteria.
DR HOGENOM; CLU_005126_9_3_6; -.
DR OMA; MMMLYMG; -.
DR PhylomeDB; P44933; -.
DR BioCyc; HINF71421:G1GJ1-950-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004771; K/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR TIGRFAMs; TIGR00932; 2a37; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Potassium; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..618
FT /note="Glutathione-regulated potassium-efflux system
FT protein"
FT /id="PRO_0000196614"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 411..533
FT /note="RCK N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
SQ SEQUENCE 618 AA; 68077 MW; 2F9AED8FCCE6B37A CRC64;
MSQLANPELM KVVILLASSV TIVPLFKRLG LGSVLGYLVA GCLIGPSVFG IVQEPTAVVH
LAELGVVMFL FIIGLEMYPE RLWAMRKAIF GRGLLQVGLC GCLLTFSGIY LLGLTKEVSF
IAGMGFTLSS TAIVMQSLEE RGLTSTSKGQ RVISTLIFED IAIVPLLASV AFLAPHSKEA
TPHTDWVSIG IALSAVVGLI VTGKWLMNPL FRLISKARIR EMMTAGALLV VLGAALAMEI
GGLSMAMGAF VAGVMMSESA FRHQLEADIE PFRGLLLGLF FMGVGMSLDL HLVFNHWILL
LGIVFLYILG KASAVYIIAR ITRLDHREAI GRMSLMAHGG EFAFVLFSAA ATAEVISNEE
QATFTAAVII SMLFSPIIAQ IARKLIQRTE PKHLDQLDEN DLDTIVDLED NVLVIGFGRF
SQIVCQTLLI RGISVSVIDR NIENIRAAAK FGFKVYYGDG IRLDVLRAAG IEKAKCVVLG
INDTQRIEHI VSQMKEAYPN LPILTRTYDR KTTVSLIKQD VDFIVRETFE SAITLSRATL
MKLGIDKIEA EEIIKEVRTL DQERLNEEVL HGFSNEIVKK YWTPRPFIKP HLDTKALNKE
TEEILSEKIE EEISNDHS
