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KEI1_SCHPO
ID   KEI1_SCHPO              Reviewed;         236 AA.
AC   O13994;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Inositol phosphorylceramide synthase regulatory subunit kei1;
DE            Short=ICP synthase regulatory subunit kei1;
GN   Name=kei1; ORFNames=SPAC26H5.13c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Regulatory component of the inositol phosphorylceramide (ICP)
CC       synthase which catalyzes the addition of a phosphorylinositol group
CC       onto ceramide to form inositol phosphorylceramide, an essential step in
CC       sphingolipid biosynthesis. Helps the medial Golgi localization of IPC
CC       synthase in a COPI vesicle-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the inositol phosphorylceramide synthase complex
CC       composed of at least aur1 and kei1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the KEI1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16198.1; -; Genomic_DNA.
DR   PIR; T38432; T38432.
DR   RefSeq; NP_594460.1; NM_001019889.2.
DR   AlphaFoldDB; O13994; -.
DR   SMR; O13994; -.
DR   STRING; 4896.SPAC26H5.13c.1; -.
DR   iPTMnet; O13994; -.
DR   PaxDb; O13994; -.
DR   PRIDE; O13994; -.
DR   EnsemblFungi; SPAC26H5.13c.1; SPAC26H5.13c.1:pep; SPAC26H5.13c.
DR   GeneID; 2541523; -.
DR   KEGG; spo:SPAC26H5.13c; -.
DR   PomBase; SPAC26H5.13c; kei1.
DR   VEuPathDB; FungiDB:SPAC26H5.13c; -.
DR   eggNOG; ENOG502S8B2; Eukaryota.
DR   HOGENOM; CLU_1180805_0_0_1; -.
DR   InParanoid; O13994; -.
DR   PRO; PR:O13994; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR   GO; GO:0070916; C:inositol phosphoceramide synthase complex; ISO:PomBase.
DR   GO; GO:0030173; C:integral component of Golgi membrane; ISO:PomBase.
DR   GO; GO:0070917; F:inositol phosphoceramide synthase regulator activity; ISO:PomBase.
DR   GO; GO:0006673; P:inositol phosphoceramide metabolic process; ISO:PomBase.
DR   GO; GO:0030148; P:sphingolipid biosynthetic process; IC:PomBase.
DR   InterPro; IPR013862; Kei1.
DR   PANTHER; PTHR28077; PTHR28077; 2.
DR   Pfam; PF08552; Kei1; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Lipid metabolism; Membrane; Reference proteome;
KW   Sphingolipid metabolism; Transmembrane; Transmembrane helix.
FT   CHAIN           1..236
FT                   /note="Inositol phosphorylceramide synthase regulatory
FT                   subunit kei1"
FT                   /id="PRO_0000341600"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   236 AA;  27112 MW;  947F8B57D7988E3F CRC64;
     MALFRRPNWS ALFEKIFIQK SFLGFCSLRV GCEIIIWFAI INKVSGLYGI VSLFQNSDAS
     PWQVLMYVSS VLMLILFSWL AIHIPKSSVP HALILFYVYL IDFLLNVLFT VLFALSWFSK
     LVQSDSSSTE ESADSDPSPS LLYLFFQAES IPSLLLLIFF ASLKFYFVLI TLSYSNKLIV
     DSGIRPQNLP PNFSGRVTRL LMKPYIMAAN RSYLRNHTKR FTDSIELEQR LMDEVV
 
 
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