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KEL3_YEAST
ID   KEL3_YEAST              Reviewed;         651 AA.
AC   Q08979; D6W3A7;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 161.
DE   RecName: Full=Kelch repeat-containing protein 3;
GN   Name=KEL3; OrderedLocusNames=YPL263C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169875;
RA   Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA   Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA   Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA   Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA   DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA   Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA   Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA   Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA   Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA   Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA   Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA   Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA   Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA   Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA   Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA   Vo D.H., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL   Nature 387:103-105(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ADR376;
RX   PubMed=17330950; DOI=10.1021/pr060559j;
RA   Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
RA   Elias J.E., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of alpha-factor-arrested
RT   Saccharomyces cerevisiae.";
RL   J. Proteome Res. 6:1190-1197(2007).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- MISCELLANEOUS: Present with 4010 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z73619; CAA97998.1; -; Genomic_DNA.
DR   EMBL; BK006949; DAA11173.1; -; Genomic_DNA.
DR   PIR; S65296; S65296.
DR   RefSeq; NP_015060.1; NM_001184077.1.
DR   AlphaFoldDB; Q08979; -.
DR   SMR; Q08979; -.
DR   BioGRID; 35950; 52.
DR   DIP; DIP-3926N; -.
DR   IntAct; Q08979; 2.
DR   MINT; Q08979; -.
DR   STRING; 4932.YPL263C; -.
DR   iPTMnet; Q08979; -.
DR   MaxQB; Q08979; -.
DR   PaxDb; Q08979; -.
DR   PRIDE; Q08979; -.
DR   EnsemblFungi; YPL263C_mRNA; YPL263C; YPL263C.
DR   GeneID; 855865; -.
DR   KEGG; sce:YPL263C; -.
DR   SGD; S000006184; KEL3.
DR   VEuPathDB; FungiDB:YPL263C; -.
DR   eggNOG; KOG1230; Eukaryota.
DR   GeneTree; ENSGT00390000003374; -.
DR   HOGENOM; CLU_008722_0_0_1; -.
DR   InParanoid; Q08979; -.
DR   OMA; GHRMTYY; -.
DR   BioCyc; YEAST:G3O-34146-MON; -.
DR   PRO; PR:Q08979; -.
DR   Proteomes; UP000002311; Chromosome XVI.
DR   RNAct; Q08979; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   Gene3D; 2.120.10.80; -; 1.
DR   InterPro; IPR025183; DUF4110.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR011498; Kelch_2.
DR   Pfam; PF13422; DUF4110; 1.
DR   Pfam; PF07646; Kelch_2; 1.
DR   SUPFAM; SSF117281; SSF117281; 1.
PE   1: Evidence at protein level;
KW   Kelch repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..651
FT                   /note="Kelch repeat-containing protein 3"
FT                   /id="PRO_0000119098"
FT   REPEAT          94..148
FT                   /note="Kelch 1"
FT   REPEAT          150..199
FT                   /note="Kelch 2"
FT   REPEAT          208..259
FT                   /note="Kelch 3"
FT   REPEAT          262..310
FT                   /note="Kelch 4"
FT   REPEAT          334..383
FT                   /note="Kelch 5"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          511..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        410..440
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..556
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        557..572
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         47
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:17330950,
FT                   ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198"
SQ   SEQUENCE   651 AA;  75433 MW;  FD0C665A6AB30843 CRC64;
     MAKKNKKDKE AKKARAELKN QKNQKKQEKK FQKNKNKSLN GEEDDESDQD LDEILSSFSK
     KQIELEHVDI TSVEKPSCRT HPLMFANPQH NKHELFIFGG EFTDPETKLT HFYNDLYSYS
     IKNNSWKKYV SQNAPLPRSS AAVAVHPSGI ALLHGGEFSS PKQSKFYHYS DTWLFDCVER
     KFTKLEFGGR DSSPSARSGH RIIAWKNYFI LFGGFRDLGN GQTSYLNDLW CFDISTYKWT
     KLETNSKPDA RSGHCFIPTD NSAILMGGYC KIIAKNNKNL MKGKILNDAW KLNLTPDPKK
     WQWEKLKNFK NQPSPRVGYS FNLWKQNKSV AFGGVYDLQE TEESLESVFY NDLYMFHLEL
     NKWSKLRIKP QRQTNSKNSP ATSKRKSNKD QEKELQDLLN SILAKSNLND DDDDNDDNST
     TGPNSIDDDE DNEDDSDLDN QEDITISNQL PHPRFNAATC VVGDSLFIYS GVWELGEKDY
     PINSFYSIDL NKLDGVKVYW EDLSAIEEAK RLGDRDSDED EFEYEDDEED EDDGEEEQDA
     GPLEGDEDEE SESDDDKQAQ MEIPDERSWL PHPKPFETLR AFYLREGANF LTWSISNNRN
     LKGKQLKTKS FELCEDRWWE RRDQVTLEEE RLEDTGGIIE RDTTTKPSKR R
 
 
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