ID   KELP_ARATH              Reviewed;         165 AA.
AC   O65155;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=RNA polymerase II transcriptional coactivator KELP;
GN   Name=KELP; OrderedLocusNames=At4g10920; ORFNames=F25I24.130, F8M12.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9681033; DOI=10.1046/j.1365-313x.1998.00169.x;
RA   Cormack R.S., Hahlbrock K., Somssich I.E.;
RT   "Isolation of putative plant transcriptional coactivators using a modified
RT   two-hybrid system incorporating a GFP reporter gene.";
RL   Plant J. 14:685-692(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: General coactivator that functions cooperatively with TAFs
CC       and mediates functional interactions between upstream activators and
CC       the general transcriptional machinery. Binds single-stranded DNA (By
CC       similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       O65155; O65154: KIWI; NbExp=9; IntAct=EBI-2112322, EBI-2112286;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transcriptional coactivator PC4 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF053303; AAC08575.1; -; mRNA.
DR   EMBL; AF080118; AAC33951.1; -; Genomic_DNA.
DR   EMBL; AL049525; CAB40060.1; -; Genomic_DNA.
DR   EMBL; AL161518; CAB81193.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE82943.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE82944.1; -; Genomic_DNA.
DR   EMBL; AY085896; AAM63108.1; -; mRNA.
DR   EMBL; BT005847; AAO64782.1; -; mRNA.
DR   PIR; T52114; T52114.
DR   RefSeq; NP_001078372.1; NM_001084903.1.
DR   RefSeq; NP_192830.1; NM_117160.4.
DR   AlphaFoldDB; O65155; -.
DR   SMR; O65155; -.
DR   BioGRID; 11989; 7.
DR   IntAct; O65155; 5.
DR   STRING; 3702.AT4G10920.2; -.
DR   iPTMnet; O65155; -.
DR   PaxDb; O65155; -.
DR   PRIDE; O65155; -.
DR   ProteomicsDB; 250687; -.
DR   DNASU; 826690; -.
DR   EnsemblPlants; AT4G10920.1; AT4G10920.1; AT4G10920.
DR   EnsemblPlants; AT4G10920.2; AT4G10920.2; AT4G10920.
DR   GeneID; 826690; -.
DR   Gramene; AT4G10920.1; AT4G10920.1; AT4G10920.
DR   Gramene; AT4G10920.2; AT4G10920.2; AT4G10920.
DR   KEGG; ath:AT4G10920; -.
DR   Araport; AT4G10920; -.
DR   TAIR; locus:2123416; AT4G10920.
DR   eggNOG; KOG2712; Eukaryota.
DR   HOGENOM; CLU_094761_0_0_1; -.
DR   InParanoid; O65155; -.
DR   OMA; DEMTEYK; -.
DR   OrthoDB; 1616655at2759; -.
DR   PhylomeDB; O65155; -.
DR   PRO; PR:O65155; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O65155; baseline and differential.
DR   Genevisible; O65155; AT.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 2.30.31.10; -; 1.
DR   InterPro; IPR014876; DEK_C.
DR   InterPro; IPR017415; KELP.
DR   InterPro; IPR003173; PC4_C.
DR   InterPro; IPR009044; ssDNA-bd_transcriptional_reg.
DR   InterPro; IPR045125; Sub1/Tcp4-like.
DR   PANTHER; PTHR13215; PTHR13215; 1.
DR   Pfam; PF08766; DEK_C; 1.
DR   Pfam; PF02229; PC4; 1.
DR   PIRSF; PIRSF038156; RNA_pol_II_KELP; 1.
DR   SUPFAM; SSF54447; SSF54447; 1.
DR   PROSITE; PS51998; DEK_C; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..165
FT                   /note="RNA polymerase II transcriptional coactivator KELP"
FT                   /id="PRO_0000215948"
FT   DOMAIN          3..60
FT                   /note="DEK-C"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01342"
FT   REGION          66..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   165 AA;  19177 MW;  6620F1693D40D3D1 CRC64;
     MEKETKEKIE KTVIEILSES DMKEITEFKV RKLASEKLAI DLSEKSHKAF VRSVVEKFLD
     EERAREYENS QVNKEEEDGD KDCGKGNKEF DDDGDLIICR LSDKRRVTIQ EFKGKSLVSI
     REYYKKDGKE LPTSKGISLT DEQWSTFKKN MPAIENAVKK MESRV