KEN1_CULQU
ID KEN1_CULQU Reviewed; 653 AA.
AC B0X9H6;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Transcription factor Ken 1 {ECO:0000250|UniProtKB:O77459};
GN Name=ken1 {ECO:0000250|UniProtKB:O77459}; ORFNames=CPIJ016082;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000312|EMBL:EDS43145.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000312|EMBL:EDS43145.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor required for terminalia development.
CC Negative regulator of the JAK/STAT pathway: represses JAK/STAT-
CC dependent expression of ventral veins lacking (vvl) in the posterior
CC spiracles (By similarity). {ECO:0000250|UniProtKB:O77459}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O77459}.
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DR EMBL; DS232537; EDS43145.1; -; Genomic_DNA.
DR RefSeq; XP_001866298.1; XM_001866263.1.
DR AlphaFoldDB; B0X9H6; -.
DR SMR; B0X9H6; -.
DR STRING; 7176.CPIJ016082-PA; -.
DR PRIDE; B0X9H6; -.
DR EnsemblMetazoa; XM_038254950.1; XP_038110878.1; LOC6049568.
DR GeneID; 6049568; -.
DR KEGG; cqu:CpipJ_CPIJ016082; -.
DR VEuPathDB; VectorBase:CPIJ016082; -.
DR VEuPathDB; VectorBase:CQUJHB012418; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_019233_0_0_1; -.
DR InParanoid; B0X9H6; -.
DR OMA; QQFVYQW; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; B0X9H6; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045497; P:female analia development; ISS:UniProtKB.
DR GO; GO:0030540; P:female genitalia development; ISS:UniProtKB.
DR GO; GO:0045496; P:male analia development; ISS:UniProtKB.
DR GO; GO:0030539; P:male genitalia development; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..653
FT /note="Transcription factor Ken 1"
FT /id="PRO_0000355089"
FT DOMAIN 35..103
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 555..577
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 583..606
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 619..641
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 126..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..269
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 71269 MW; 89C20764120FCCC1 CRC64;
MCSKRELRML MLHYSKHGEC ILQEIGAAFR GEHATDLLLI CDGKETVRAH KLVLAAASPL
IRMILEETPV LDGVTTVYFP EVQVSYFRLL LDFLYSGQVY VRSVEEYHHL QDLLALLQIK
ASIWKNSDGS GEGEPRKSEP LVDINRNTEG ITGSSVVHQH PSRRRRSKSQ DSLSGDSASG
GGGTGSQAGT PKKVSVKSER HSAGSSVDGD GDRDREENLE YLDEVEEAII KSNNNHPLHP
HQHHLVAGSG GHHHHHHHHH HHRQLHQIKT RSRRSDPSAN RRRSSSDPVN LSIVKQQQDV
DSDDANIDVE TIGTATTKTL LPPRYLDPFR TKRKAAAYYI HPADAEALKP MDHEGLLHNS
PDNYVVTPHR KRRPGFHNSP AQNPPFVPSY LDDLRARSKC FLSAPPTYLP ELRPGSPTSV
RHAEIAAGLS NNNNSSSNNN NNNNRIRPPS ADNKLAVAPF VYPWPTAALA GLPGGPSDLL
GLPYVHGGGP NAETSPADLL QQMKNFENSQ AELSARASAA GGGGGGSGGN GSGSGGVASG
GGGGSMGGNT AVREYRCEYC GKTFGMSWNL KTHLRVHTGE KPFACRLCVA MFKQKAHLLK
HLCSVHRNII NAPEAGGRYT CCFCSLVFET LQELVRHLSG HHNNLLLSKN LHE
