KEN2_CULQU
ID KEN2_CULQU Reviewed; 670 AA.
AC B0X0K1;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Transcription factor Ken 2 {ECO:0000250|UniProtKB:O77459};
GN Name=ken2 {ECO:0000250|UniProtKB:O77459}; ORFNames=CPIJ012629;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000312|EMBL:EDS38162.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000312|EMBL:EDS38162.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor required for terminalia development.
CC Negative regulator of the JAK/STAT pathway: represses JAK/STAT-
CC dependent expression of ventral veins lacking (vvl) in the posterior
CC spiracles (By similarity). {ECO:0000250|UniProtKB:O77459}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O77459}.
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DR EMBL; DS232239; EDS38162.1; -; Genomic_DNA.
DR RefSeq; XP_001863173.1; XM_001863138.1.
DR AlphaFoldDB; B0X0K1; -.
DR STRING; 7176.CPIJ012629-PA; -.
DR KEGG; cqu:CpipJ_CPIJ012629; -.
DR VEuPathDB; VectorBase:CPIJ012629; -.
DR VEuPathDB; VectorBase:CQUJHB012418; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_019233_0_0_1; -.
DR InParanoid; B0X0K1; -.
DR OMA; HIRIRMI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; B0X0K1; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045497; P:female analia development; ISS:UniProtKB.
DR GO; GO:0030540; P:female genitalia development; ISS:UniProtKB.
DR GO; GO:0045496; P:male analia development; ISS:UniProtKB.
DR GO; GO:0030539; P:male genitalia development; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..670
FT /note="Transcription factor Ken 2"
FT /id="PRO_0000355090"
FT DOMAIN 108..176
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 586..594
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 600..623
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 636..658
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 200..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..339
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..423
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 73609 MW; 5BCD3EAF960400BF CRC64;
MEVLKLCLLL TRKKQFEVEL IPEKIGARRP WKLETSSTAT EAVVSVVTYL EATSGNARDA
KEAGIYIRVY GAGWMIPEFV RMLMLHYSKH GECILQEIGA AFRGEHATDL LLICDGKETV
RAHKLVLAAA SPLIRMILEE TPVLDGVTTV YFPEVQVSYF RLLLDFLYSG QVYVRSVEEY
HHLQDLLALL QIKASIWKNS DGSDAGEPRK SEPLVDINRN TEGITGSSVV HQHPSRRRRS
KSQDSLSGDS ASGGGGTGSQ AGTPKKVSVK SERHSAGSSV DGDGDRDREE NLEYLDEVEE
AIIKSNNNHP LHPHQHHLVA GSGGHHLHHH HHHHHRQLHQ ISRHDGDDDA GGGSGNDGAS
EGGSGESGRA GSVAGESAGD RPTPTNLSSG GGGAGSGRRS GSGEPTEPAE DDEDYELDVE
DRGGDGDEAA GEGETRSRRS DPSANRRRSS SDPVNLSIVK QQQDVDSDDA NIDVETIGTA
TTKTLLPPRY LDPFRTKRKA AAYYIHPADA EALKPMDHEG LLHNSPDNYV VTPHRKRRPG
FHNSPAQNPP FVPSYLDDLR ARSKCFLSAP PTYLPEKYLS VLTRWNLKTH LRVHTGEKPF
ACRLCVAMFK QKAHLLKHLC SVHRNIINAP EAGGRYTCCF CSLVFETLQE LVRHLSGHHN
NLLLSKNLHE
