KEN_DROPS
ID KEN_DROPS Reviewed; 569 AA.
AC Q292R5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Transcription factor Ken {ECO:0000250|UniProtKB:O77459};
DE AltName: Full=Protein Ken and Barbie;
GN Name=ken {ECO:0000250|UniProtKB:O77459}; ORFNames=GA18980;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Transcription factor required for terminalia development.
CC Negative regulator of the JAK/STAT pathway: represses JAK/STAT-
CC dependent expression of ventral veins lacking (vvl) in the posterior
CC spiracles (By similarity). {ECO:0000250|UniProtKB:O77459}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O77459}.
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DR EMBL; CM000071; EAL24796.2; -; Genomic_DNA.
DR RefSeq; XP_001360222.2; XM_001360185.3.
DR AlphaFoldDB; Q292R5; -.
DR SMR; Q292R5; -.
DR STRING; 7237.FBpp0277351; -.
DR EnsemblMetazoa; FBtr0278913; FBpp0277351; FBgn0078979.
DR GeneID; 4803509; -.
DR KEGG; dpo:Dpse_GA18980; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_019233_0_0_1; -.
DR InParanoid; Q292R5; -.
DR OMA; QQFVYQW; -.
DR Proteomes; UP000001819; Chromosome 3.
DR Bgee; FBgn0078979; Expressed in female reproductive system and 3 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045497; P:female analia development; ISS:UniProtKB.
DR GO; GO:0030540; P:female genitalia development; ISS:UniProtKB.
DR GO; GO:0045496; P:male analia development; ISS:UniProtKB.
DR GO; GO:0030539; P:male genitalia development; ISS:UniProtKB.
DR GO; GO:0046426; P:negative regulation of receptor signaling pathway via JAK-STAT; IEA:EnsemblMetazoa.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..569
FT /note="Transcription factor Ken"
FT /id="PRO_0000355091"
FT DOMAIN 33..101
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 468..490
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 496..519
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 535..557
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 179..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 63301 MW; 923F14F30271DC36 CRC64;
MKEFQRMLML QYSKHGECIL KEIGAAFRGE HPADLTIVCE NKVKLHAHKL VLAAASPLIR
NLLEDTHLSD CSTTVYFPDV NATYFKFLLD FLYSGQTCIT SRDVNYLHDL LLLLQIKSDS
WKTTDSAYLN SKCGSIRERS RKQYSSSQNL DQTLKYEVDS VDESRNAADF SACSAEHCES
APECGGGGVA KEEDDECTHK DNRSEKDTDE IVNLSNAPPS GISNHSNTNS NSSNNNNNNS
AINPVNLSLD LRTKSENSAR SDASRTIGSG SDHSGIDLAI SASESTKRKG LFFDSHKDVL
KPLSDGSDIN SSPENYVVTP HRKRRPGFHN TQSDNQPFTS YQQNLLEELR LVKSTTSPIS
GFSSEKNMLA HLEDGALNGD TLTPDRKLIE SQRNHAQSPD IPMHLGPQFV YQWQSNQNAA
ISAMPNLQSR LSSLSHMNLG LDPEGRSSSA SGSNIASSNP HSSSVREYRC EYCGKQFGMS
WNLKTHLRVH TGEKPFACRL CVAMFKQKAH LLKHLCSVHR NIITTTNGTD TENRYSCCFC
SMCFESVQEL VRHLSGHHNN LLLTKNLRE
