ID   KES1_SCHPO              Reviewed;         388 AA.
AC   O74178; Q7LWB8;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1999, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Protein kes1;
GN   Name=kes1; ORFNames=SPBC1271.12;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3-388.
RA   Kawamukai M.;
RT   "S.pombe KES1/HES1 homolog.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lipid transporter involved in lipid countertransport between
CC       the Golgi complex and membranes of the endoplasmic reticulum:
CC       specifically exchanges sterol with phosphatidylinositol 4-phosphate
CC       (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is
CC       degraded by the SAC1 phosphatase in the endoplasmic reticulum.
CC       {ECO:0000250|UniProtKB:P35844}.
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA22202.1; -; Genomic_DNA.
DR   EMBL; AB016222; BAA31746.1; -; mRNA.
DR   PIR; T39348; T39348.
DR   PIR; T43391; T43391.
DR   RefSeq; NP_595138.1; NM_001021046.2.
DR   AlphaFoldDB; O74178; -.
DR   SMR; O74178; -.
DR   BioGRID; 276739; 5.
DR   STRING; 4896.SPBC1271.12.1; -.
DR   iPTMnet; O74178; -.
DR   MaxQB; O74178; -.
DR   PaxDb; O74178; -.
DR   PRIDE; O74178; -.
DR   EnsemblFungi; SPBC1271.12.1; SPBC1271.12.1:pep; SPBC1271.12.
DR   PomBase; SPBC1271.12; kes1.
DR   VEuPathDB; FungiDB:SPBC1271.12; -.
DR   eggNOG; KOG2210; Eukaryota.
DR   HOGENOM; CLU_012334_0_2_1; -.
DR   InParanoid; O74178; -.
DR   OMA; SSYWTEH; -.
DR   PhylomeDB; O74178; -.
DR   Reactome; R-SPO-1482801; Acyl chain remodelling of PS.
DR   Reactome; R-SPO-192105; Synthesis of bile acids and bile salts.
DR   PRO; PR:O74178; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0008142; F:oxysterol binding; ISO:PomBase.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0120015; F:sterol transfer activity; ISO:PomBase.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   GO; GO:0006629; P:lipid metabolic process; NAS:PomBase.
DR   GO; GO:0015918; P:sterol transport; ISO:PomBase.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..388
FT                   /note="Protein kes1"
FT                   /id="PRO_0000232937"
SQ   SEQUENCE   388 AA;  44592 MW;  E5B523A1589E402D CRC64;
     MSKTTSSDDS RDGEGDKRLR STTKSTWLSF LKSIATFSGD LSSLTAPSFI LSSTSLIEYS
     AYWAEHPELF ISLPRGETPL ERQLLVTKWF ASTLKNQYAA RNERYGSEKK PLNPILGELF
     TGKWNTDIGE DTELTSEQVS HHPPITAYHI YNKKAGVRLE GYNGHKSGFS GPQIHVKQIG
     HARLILEPHN EVYYITFPLV TLEGLWYGSP YIELGKKSYI ISTSGYLTTI EYSGKGYFTG
     KKNTFKATIV NAKTKSEPIY RIEGSWTGML KYCTFEDQKR SAWEDFLDCG NYKPVNISVA
     PIEEQGEYES RRVWKNFAVA LDAGDYAAAS QEKSKIEEGQ RELRRQEEEH NEVWHRKYFE
     WKDKDEGFEE ATKCLRQPVK EGFWYYLR