ID   KES1_USTMA              Reviewed;         383 AA.
AC   P0C199; A0A0D1CP29; Q4P8S3;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Protein KES1;
GN   Name=KES1; ORFNames=UMAG_11086;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lipid transporter involved in lipid countertransport between
CC       the Golgi complex and membranes of the endoplasmic reticulum:
CC       specifically exchanges sterol with phosphatidylinositol 4-phosphate
CC       (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is
CC       degraded by the SAC1 phosphatase in the endoplasmic reticulum.
CC       {ECO:0000250|UniProtKB:P35844}.
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
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DR   EMBL; CM003148; KIS68398.1; -; Genomic_DNA.
DR   RefSeq; XP_011390093.1; XM_011391791.1.
DR   AlphaFoldDB; P0C199; -.
DR   SMR; P0C199; -.
DR   STRING; 237631.P0C199; -.
DR   EnsemblFungi; KIS68398; KIS68398; UMAG_11086.
DR   GeneID; 23567015; -.
DR   KEGG; uma:UMAG_11086; -.
DR   VEuPathDB; FungiDB:UMAG_11086; -.
DR   InParanoid; P0C199; -.
DR   OrthoDB; 949920at2759; -.
DR   Proteomes; UP000000561; Chromosome 9.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0008142; F:oxysterol binding; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..383
FT                   /note="Protein KES1"
FT                   /id="PRO_0000232938"
FT   REGION          317..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   383 AA;  42364 MW;  3168083003507AC0 CRC64;
     MGEEDIGEAV PKEQRQGWGQ FLKQIATFSG DLSSLTAPSF ILSPVSLVEF PAYWGEHPDE
     FAKISTGKDE IERMNLVLKW FIGTLKGQFT ARNTSMGSEK KPLNPILGEL FLGKWPDKND
     RGETTLTAEQ VSHHPPVTAY HIENRKAGVT LEGHCAQKTS FSGRTIQVKQ VGHAILRVKL
     AGSDKEELYL ITLPNLLIEG LWYGAPYVEL TGNSYIQSTT CLLTTLSYTG KGYFSGKAHS
     FKATIGAGGN ALYTVEGEWA GVSKYKGKSV SGGSNELFWD ASTQREEVSV EAVEQQGEME
     SRKVWKTVAH GIRSGDFETA SKDKARIENA QRQKRKDEAA AGTPHQLERF VHLDNDQEYS
     QLAAMFKGQP ATEDGYRSKP RVH