KF22B_XENLA
ID KF22B_XENLA Reviewed; 650 AA.
AC Q7ZYL5; Q6GPG0; Q9I9A8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Kinesin-like protein KIF22-B;
DE AltName: Full=Chromokinesin kid-B;
DE Short=Xkid-B;
GN Name=kif22-b; Synonyms=kid-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Oocyte;
RX PubMed=10966105; DOI=10.1016/s0092-8674(00)00048-9;
RA Antonio C., Ferby I., Wilhelm H., Jones M., Karsenti E., Nebreda A.R.,
RA Vernos I.;
RT "Xkid, a chromokinesin required for chromosome alignment on the metaphase
RT plate.";
RL Cell 102:425-435(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Kinesin family member that is involved in spindle formation
CC and the movements of chromosomes during mitosis and meiosis. Binds to
CC microtubules and to DNA. {ECO:0000250|UniProtKB:Q9I869}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9I869}.
CC Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- PTM: Ubiquitinated, leading to its subsequent proteasomal degradation.
CC {ECO:0000250|UniProtKB:Q9I869}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH73177.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ249841; CAB71799.1; -; mRNA.
DR EMBL; BC043733; AAH43733.1; -; mRNA.
DR EMBL; BC073177; AAH73177.1; ALT_INIT; mRNA.
DR RefSeq; NP_001165449.1; NM_001171978.1.
DR AlphaFoldDB; Q7ZYL5; -.
DR SMR; Q7ZYL5; -.
DR BioGRID; 1078895; 3.
DR IntAct; Q7ZYL5; 1.
DR DNASU; 100337511; -.
DR GeneID; 100337511; -.
DR KEGG; xla:100337511; -.
DR CTD; 100337511; -.
DR Xenbase; XB-GENE-6464372; kif22.L.
DR OrthoDB; 787964at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 100337511; Expressed in egg cell and 17 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR026986; KIF22.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR PANTHER; PTHR24115:SF801; PTHR24115:SF801; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; DNA-binding;
KW Microtubule; Motor protein; Nucleotide-binding; Nucleus;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..650
FT /note="Kinesin-like protein KIF22-B"
FT /id="PRO_0000347239"
FT DOMAIN 31..359
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 365..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 452..498
FT /evidence="ECO:0000255"
FT MOTIF 560..563
FT /note="Important for regulated proteolytic degradation"
FT /evidence="ECO:0000250"
FT COMPBIAS 378..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 116..123
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT CONFLICT 18
FT /note="V -> A (in Ref. 1; CAB71799)"
FT /evidence="ECO:0000305"
FT CONFLICT 161
FT /note="Y -> H (in Ref. 1; CAB71799)"
FT /evidence="ECO:0000305"
FT CONFLICT 214
FT /note="E -> A (in Ref. 1; CAB71799)"
FT /evidence="ECO:0000305"
FT CONFLICT 522
FT /note="V -> A (in Ref. 1; CAB71799)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 650 AA; 73168 MW; 536088541FCE5353 CRC64;
MVLTGPPQRE SVSMVKRVSM LDQHKKSSCA RVRVAVRLRP YMEEKEEDKV PTACVRGLDS
HSLEIVNWRN QLETMQYQFD AFYGDSASQR EIYMGSVCHI LPHLLIGQNA SVFAYGPTGA
GKTHTMLGNP DQPGVIPRAV RELLQMTRMA ASAPENENWT YTITMSYVEI YQEKVMDLLE
PKNKDLPIRE DKDHNILIPG VTLKTINSFG DFDEHFIPAS QNRTVASTKL NDRSSRSHAV
LLIKVQKSQQ VAPFRQLIGK LYLIDLAGSE DNRRTGNQGI RLKESGAINS SLFTLSKVVD
ALNQGLPRIP YRDSKLTRLL QDSLGGSAHS VMITNIAPEQ TYYFDTLTAL NFAAKSKQII
NKPFSRETTQ TVAQPAMKRP REEAEATTSS RQRKKSKTDS TESSPNSSME STGKRKLNLA
SLDSAVVERL LKLDKILTEK GKKEAQLLST PKRERMALLK KWEESQMEIE RLKEKQKELE
QKAMEAEARL EKSNNSDLSD SSVSENTFRA PLRGRNTSTA KVKKVLRVLP MQGNSQLQST
IEEGIPVFEK KKKKQVTCDG HENQPTWEMN MRTDLLESGK ERILKLLNTG SVKELKSLQR
IGDKKAKLII GWREVNGLFK NVEELECLEG ISAKQVSSFI KANILSSISS
