ID   KGUA_CAMJE              Reviewed;         207 AA.
AC   Q9PNB8; O32356; Q0P979;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Guanylate kinase;
DE            EC=2.7.4.8;
DE   AltName: Full=GMP kinase;
GN   Name=gmk; OrderedLocusNames=Cj1177;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-126.
RC   STRAIN=ATCC 700819 / NCTC 11168;
RA   Karlyshev A.V., Wren B.W.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:456216; EC=2.7.4.8;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the guanylate kinase family. {ECO:0000305}.
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DR   EMBL; AL111168; CAL35292.1; -; Genomic_DNA.
DR   EMBL; AJ000744; CAA04292.1; -; Genomic_DNA.
DR   PIR; C81323; C81323.
DR   RefSeq; WP_002860253.1; NC_002163.1.
DR   RefSeq; YP_002344568.1; NC_002163.1.
DR   AlphaFoldDB; Q9PNB8; -.
DR   SMR; Q9PNB8; -.
DR   IntAct; Q9PNB8; 50.
DR   STRING; 192222.Cj1177c; -.
DR   PaxDb; Q9PNB8; -.
DR   PRIDE; Q9PNB8; -.
DR   EnsemblBacteria; CAL35292; CAL35292; Cj1177c.
DR   GeneID; 905467; -.
DR   KEGG; cje:Cj1177c; -.
DR   PATRIC; fig|192222.6.peg.1158; -.
DR   eggNOG; COG0194; Bacteria.
DR   HOGENOM; CLU_001715_1_2_7; -.
DR   OMA; EWAVVHG; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004385; F:guanylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00328; Guanylate_kinase; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR017665; Guanylate_kinase.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03263; guanyl_kin; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW   Transferase.
FT   CHAIN           1..207
FT                   /note="Guanylate kinase"
FT                   /id="PRO_0000170515"
FT   DOMAIN          5..185
FT                   /note="Guanylate kinase-like"
FT   BINDING         12..19
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        81
FT                   /note="F -> V (in Ref. 2; CAA04292)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   207 AA;  24025 MW;  F258896CD6EE1AC2 CRC64;
     MKLQGFVLLI SGPSGAGKST LLKKLFDEFE DELYFSISST TRKPREGEKN GIHYHFISHE
     EFQKGIDSDH FLEWARVHEN FYGTSLKHTQ NALDNGKIVV FDIDVQGFKI ARKKMADKIV
     SVFITTKNKD ELKKRLIKRN TDTIIQLEKR LQNASDEMKE LSEYDYLIIN DELKQSYEAL
     RAILIAHKFR TKGQNLGQIQ NIWNEGE