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KGUA_LACLA
ID   KGUA_LACLA              Reviewed;         205 AA.
AC   Q9CEE3;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Guanylate kinase;
DE            EC=2.7.4.8;
DE   AltName: Full=GMP kinase;
GN   Name=gmk; OrderedLocusNames=LL1899; ORFNames=L149828;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:456216; EC=2.7.4.8;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the guanylate kinase family. {ECO:0000305}.
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DR   EMBL; AE005176; AAK05997.1; -; Genomic_DNA.
DR   PIR; C86862; C86862.
DR   RefSeq; NP_268056.1; NC_002662.1.
DR   RefSeq; WP_003131468.1; NC_002662.1.
DR   AlphaFoldDB; Q9CEE3; -.
DR   SMR; Q9CEE3; -.
DR   STRING; 272623.L149828; -.
DR   PaxDb; Q9CEE3; -.
DR   EnsemblBacteria; AAK05997; AAK05997; L149828.
DR   GeneID; 60356363; -.
DR   GeneID; 66442904; -.
DR   KEGG; lla:L149828; -.
DR   PATRIC; fig|272623.7.peg.2034; -.
DR   eggNOG; COG0194; Bacteria.
DR   HOGENOM; CLU_001715_1_0_9; -.
DR   OMA; EWAVVHG; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004385; F:guanylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00328; Guanylate_kinase; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR017665; Guanylate_kinase.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03263; guanyl_kin; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW   Transferase.
FT   CHAIN           1..205
FT                   /note="Guanylate kinase"
FT                   /id="PRO_0000170551"
FT   DOMAIN          5..183
FT                   /note="Guanylate kinase-like"
FT   BINDING         12..19
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   205 AA;  23623 MW;  17DAA417A31A2DED CRC64;
     MRERGLLIVF SGPSGVGKGT VRAKIFESEN NFEYSVSMTT RKQRPGEVDG KDYYFRTRDE
     FEEMIRNGQM LEYAEYVGNY YGTPLTYVNQ TLDEGKDVFL EIEVQGALQV KEKVPDGVFV
     FLTPPDLEEL RGRLVGRGTD SAEVIASRLE KAKEEIRLMS EYDYAVVNDK VELAAERVKK
     IIEAEHYRVD RVIERYVHMI DDVKV
 
 
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