KGUA_LACLA
ID KGUA_LACLA Reviewed; 205 AA.
AC Q9CEE3;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Guanylate kinase;
DE EC=2.7.4.8;
DE AltName: Full=GMP kinase;
GN Name=gmk; OrderedLocusNames=LL1899; ORFNames=L149828;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189,
CC ChEBI:CHEBI:456216; EC=2.7.4.8;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the guanylate kinase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE005176; AAK05997.1; -; Genomic_DNA.
DR PIR; C86862; C86862.
DR RefSeq; NP_268056.1; NC_002662.1.
DR RefSeq; WP_003131468.1; NC_002662.1.
DR AlphaFoldDB; Q9CEE3; -.
DR SMR; Q9CEE3; -.
DR STRING; 272623.L149828; -.
DR PaxDb; Q9CEE3; -.
DR EnsemblBacteria; AAK05997; AAK05997; L149828.
DR GeneID; 60356363; -.
DR GeneID; 66442904; -.
DR KEGG; lla:L149828; -.
DR PATRIC; fig|272623.7.peg.2034; -.
DR eggNOG; COG0194; Bacteria.
DR HOGENOM; CLU_001715_1_0_9; -.
DR OMA; EWAVVHG; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004385; F:guanylate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00328; Guanylate_kinase; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR017665; Guanylate_kinase.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00625; Guanylate_kin; 1.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03263; guanyl_kin; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW Transferase.
FT CHAIN 1..205
FT /note="Guanylate kinase"
FT /id="PRO_0000170551"
FT DOMAIN 5..183
FT /note="Guanylate kinase-like"
FT BINDING 12..19
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 205 AA; 23623 MW; 17DAA417A31A2DED CRC64;
MRERGLLIVF SGPSGVGKGT VRAKIFESEN NFEYSVSMTT RKQRPGEVDG KDYYFRTRDE
FEEMIRNGQM LEYAEYVGNY YGTPLTYVNQ TLDEGKDVFL EIEVQGALQV KEKVPDGVFV
FLTPPDLEEL RGRLVGRGTD SAEVIASRLE KAKEEIRLMS EYDYAVVNDK VELAAERVKK
IIEAEHYRVD RVIERYVHMI DDVKV