ID   KGUA_MESFL              Reviewed;         297 AA.
AC   Q6F1S1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Guanylate kinase;
DE            EC=2.7.4.8;
DE   AltName: Full=GMP kinase;
GN   Name=gmk; OrderedLocusNames=Mfl195;
OS   Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)
OS   (Acholeplasma florum).
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales; Entomoplasmataceae;
OC   Mesoplasma.
OX   NCBI_TaxID=265311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33453 / NBRC 100688 / NCTC 11704 / L1;
RA   Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S.,
RA   Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:456216; EC=2.7.4.8;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the guanylate kinase family. {ECO:0000305}.
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DR   EMBL; AE017263; AAT75552.1; -; Genomic_DNA.
DR   RefSeq; WP_011183092.1; NC_006055.1.
DR   RefSeq; YP_053436.1; NC_006055.1.
DR   AlphaFoldDB; Q6F1S1; -.
DR   SMR; Q6F1S1; -.
DR   STRING; 265311.Mfl195; -.
DR   EnsemblBacteria; AAT75552; AAT75552; Mfl195.
DR   GeneID; 2898173; -.
DR   KEGG; mfl:Mfl195; -.
DR   PATRIC; fig|265311.5.peg.196; -.
DR   eggNOG; COG0194; Bacteria.
DR   HOGENOM; CLU_001715_1_0_14; -.
DR   OMA; FLMPPTL; -.
DR   Proteomes; UP000006647; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004385; F:guanylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00328; Guanylate_kinase; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR017665; Guanylate_kinase.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03263; guanyl_kin; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW   Transferase.
FT   CHAIN           1..297
FT                   /note="Guanylate kinase"
FT                   /id="PRO_0000266346"
FT   DOMAIN          5..184
FT                   /note="Guanylate kinase-like"
FT   REGION          205..297
FT                   /note="Unknown"
FT   BINDING         12..19
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   297 AA;  33826 MW;  94B819C9B7191BA2 CRC64;
     MKNKGKVIII SGPSGVGKGS VNGELLTNKD LKLEYSVSMT TRAPREGEVN GVNYFFVSKE
     EFANAIVNNE LIEYANFVGN SYGTPRKYVE EKLNEGKNVI LEIEVDGATQ VLRNEENVLS
     IFLMPPTLNE LESRIKGRAT ESDDKIKARL DKALLEIPLK HNYDYVVEND SVENAVSKIT
     DILIREKCTE SNEESKFKEL VKIVENIVDQ KYTYFINNWE ANVKLLAHNK EAKKEANDFD
     ARGELIKILS SEVYRKTLAH GDFSKINDVE YVDFKIQKLM FKINFFSIKQ RSDFSGD