ID   KGUA_PSEAE              Reviewed;         203 AA.
AC   Q9HTM2;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Guanylate kinase;
DE            EC=2.7.4.8;
DE   AltName: Full=GMP kinase;
GN   Name=gmk; OrderedLocusNames=PA5336;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + GMP = ADP + GDP; Xref=Rhea:RHEA:20780,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:456216; EC=2.7.4.8;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the guanylate kinase family. {ECO:0000305}.
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DR   EMBL; AE004091; AAG08721.1; -; Genomic_DNA.
DR   PIR; F82978; F82978.
DR   RefSeq; NP_254023.1; NC_002516.2.
DR   RefSeq; WP_003098317.1; NZ_QZGE01000020.1.
DR   PDB; 7U5F; X-ray; 2.00 A; A/B/C/D=1-203.
DR   PDBsum; 7U5F; -.
DR   AlphaFoldDB; Q9HTM2; -.
DR   SMR; Q9HTM2; -.
DR   STRING; 287.DR97_2707; -.
DR   PaxDb; Q9HTM2; -.
DR   PRIDE; Q9HTM2; -.
DR   DNASU; 878047; -.
DR   EnsemblBacteria; AAG08721; AAG08721; PA5336.
DR   GeneID; 878047; -.
DR   KEGG; pae:PA5336; -.
DR   PATRIC; fig|208964.12.peg.5591; -.
DR   PseudoCAP; PA5336; -.
DR   HOGENOM; CLU_001715_1_0_6; -.
DR   InParanoid; Q9HTM2; -.
DR   OMA; EWAVVHG; -.
DR   PhylomeDB; Q9HTM2; -.
DR   BioCyc; PAER208964:G1FZ6-5458-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004385; F:guanylate kinase activity; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00328; Guanylate_kinase; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR017665; Guanylate_kinase.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03263; guanyl_kin; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..203
FT                   /note="Guanylate kinase"
FT                   /id="PRO_0000170587"
FT   DOMAIN          3..181
FT                   /note="Guanylate kinase-like"
FT   BINDING         10..17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   203 AA;  23102 MW;  DE35644BBE88623A CRC64;
     MSGTLYIVSA PSGAGKTSLV KALLDAAPEV RVSVSHTTRG MRPGEVDGVN YHFTSREEFL
     AMLERNEFLE HAEVFGNLYG TSQRWVEKTL AEGLDLILEI DWQGAQQVRR LMPEAQSIFI
     LPPSQEALRQ RLTNRGQDSD EVIERRMREA VSEMSHYVEY DHLVINDDFA HALDDLKAIF
     RARQLRQDAQ QQRHAELLGR LLA