KHA1_SCHPO
ID KHA1_SCHPO Reviewed; 889 AA.
AC Q9P7I1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=K(+)/H(+) antiporter 1;
GN Name=kha1; ORFNames=SPAC105.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: Potassium-proton antiport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000305}.
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DR EMBL; CU329670; CAB76234.2; -; Genomic_DNA.
DR PIR; T50062; T50062.
DR RefSeq; NP_593465.2; NM_001018898.2.
DR AlphaFoldDB; Q9P7I1; -.
DR SMR; Q9P7I1; -.
DR BioGRID; 279433; 4.
DR STRING; 4896.SPAC105.01c.1; -.
DR iPTMnet; Q9P7I1; -.
DR MaxQB; Q9P7I1; -.
DR PaxDb; Q9P7I1; -.
DR PRIDE; Q9P7I1; -.
DR EnsemblFungi; SPAC105.01c.1; SPAC105.01c.1:pep; SPAC105.01c.
DR GeneID; 2542995; -.
DR KEGG; spo:SPAC105.01c; -.
DR PomBase; SPAC105.01c; kha1.
DR VEuPathDB; FungiDB:SPAC105.01c; -.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_10_1_1; -.
DR InParanoid; Q9P7I1; -.
DR OMA; LYHVCIV; -.
DR PRO; PR:Q9P7I1; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:PomBase.
DR GO; GO:0015386; F:potassium:proton antiporter activity; ISS:PomBase.
DR GO; GO:0030007; P:cellular potassium ion homeostasis; ISS:PomBase.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..889
FT /note="K(+)/H(+) antiporter 1"
FT /id="PRO_0000317080"
FT TOPO_DOM 1..11
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..146
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..322
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..364
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 410..857
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 858..878
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 879..889
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 889 AA; 98953 MW; 5A967B8E2F9E265D CRC64;
MSTQSIFDGD NVVVYSASDP LLLFIVQAII IIALCRLIHI PLSFLQQPRV IAEIIGGIVL
GPTVMGRIPK FLDYIFPTSS MGPLNLVSNL GLVLFLFVIG MEVDLRVLVL NYKVTLLVTV
FSIVIPFGAG AGISAGLYKF TTREFEFGKF LLFISTAMSI TAFPVLARIL SELHLLHKRV
GVIVLSAGIG NDVIGWILLA LSVTLVNSGS GVRAVYILLL ALGWCLFLFI AIKPLVYLLA
VKTRSLKDKP SESFICIVLS MVLVSAFFTD IIGIHPIFGG FLVGTIIPHE NDLTVKITEK
IEDLVNCLFL PLYFASSGLK TNISTLNTGK IWGYTIGTIC VAIASKMGSS MLAARILKMP
WSDSLVVGSL MSCKGLVELI VLNIGLSTGI LNETIFSMFV FMAVITTFVT TPMTKFFLRF
TKSEHDDNSI ESSEELVQYL PELPTRLSFL INHPLDASAA MIFIQHIYEN RDKVSGCLHL
PQIIIHSIWT LFVDSRTSNL LRASQVDNKV ENEALMGLFE TFVKIKKFEY ESNALLVSGT
GYYNVVLETL KKSSSNILIM PYLKDYKTIE NESSSSPLSL SSIRLALGDS FKSLDELIPL
IKMARIPVGV FFTRNPHNLS VKKIRPIIRS TEYGSPKNDF EQLEKDKKSF DQVEISVKEK
GSTYERSKVV ILIYLGTEND LIALELLLKF LYEETSIAYI YTYDEFYKDD YATSLPNVVY
TSEVLLSKHN DSAFKVWPKL RKNIRKITKP NGFTTDQHSQ TFIPSQTHTK LDLRLSDVTD
SVRSRINVVK FGNLNSLLSC LHELIQPATL TPSFETEKSI TMFLGCRDKQ AVSEKLEVAA
LSEMKKLGYI ESSSEFGMLA GLIPLVLLSN FPLIDFFLGK APTKMVQGY
