KHD1A_MOUSE
ID KHD1A_MOUSE Reviewed; 166 AA.
AC Q3UWR2; Q7TNM0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=KH homology domain-containing protein 1A;
DE AltName: Full=Nur77 downstream gene 1 protein;
GN Name=Khdc1a; Synonyms=Ndg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RC STRAIN=C57BL/6J;
RX PubMed=14657025; DOI=10.1093/emboj/cdg620;
RA Rajpal A., Cho Y.A., Yelent B., Koza-Taylor P.H., Li D., Chen E., Whang M.,
RA Kang C., Turi T.G., Winoto A.;
RT "Transcriptional activation of known and novel apoptotic pathways by Nur77
RT orphan steroid receptor.";
RL EMBO J. 22:6526-6536(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Has pro-apoptotic activity. {ECO:0000269|PubMed:14657025}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14657025}.
CC -!- INDUCTION: By NR4A1/NUR77. {ECO:0000269|PubMed:14657025}.
CC -!- SIMILARITY: Belongs to the KHDC1 family. {ECO:0000305}.
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DR EMBL; AY238603; AAP51210.1; -; mRNA.
DR EMBL; AK136166; BAE22852.1; -; mRNA.
DR CCDS; CCDS14848.1; -.
DR RefSeq; NP_899145.2; NM_183322.2.
DR AlphaFoldDB; Q3UWR2; -.
DR STRING; 10090.ENSMUSP00000085749; -.
DR PaxDb; Q3UWR2; -.
DR PRIDE; Q3UWR2; -.
DR DNASU; 368204; -.
DR Ensembl; ENSMUST00000088407; ENSMUSP00000085749; ENSMUSG00000067750.
DR GeneID; 368204; -.
DR KEGG; mmu:368204; -.
DR UCSC; uc007aln.1; mouse.
DR CTD; 368204; -.
DR MGI; MGI:2676610; Khdc1a.
DR VEuPathDB; HostDB:ENSMUSG00000067750; -.
DR eggNOG; ENOG502TCCK; Eukaryota.
DR GeneTree; ENSGT00940000154353; -.
DR HOGENOM; CLU_102222_0_1_1; -.
DR InParanoid; Q3UWR2; -.
DR OMA; CEPLAIG; -.
DR OrthoDB; 1594877at2759; -.
DR PhylomeDB; Q3UWR2; -.
DR TreeFam; TF337964; -.
DR BioGRID-ORCS; 368204; 1 hit in 37 CRISPR screens.
DR ChiTaRS; Khdc1a; mouse.
DR PRO; PR:Q3UWR2; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3UWR2; protein.
DR Bgee; ENSMUSG00000067750; Expressed in animal zygote and 21 other tissues.
DR Genevisible; Q3UWR2; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IDA:MGI.
DR GO; GO:0008266; F:poly(U) RNA binding; IDA:MGI.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd12795; FILIA_N_like; 1.
DR Gene3D; 3.30.1370.10; -; 1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR031952; MOEP19_KH-like.
DR Pfam; PF16005; MOEP19; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; Reference proteome; RNA-binding.
FT CHAIN 1..166
FT /note="KH homology domain-containing protein 1A"
FT /id="PRO_0000311433"
FT DOMAIN 19..78
FT /note="KH; atypical"
FT CONFLICT 21
FT /note="V -> A (in Ref. 1; AAP51210)"
FT /evidence="ECO:0000305"
FT CONFLICT 28
FT /note="K -> R (in Ref. 1; AAP51210)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 166 AA; 19690 MW; BB4FC5FD844145F3 CRC64;
MSDLRRKGWW NVPDYFHSPL VFDMEEDKED YIFGPHDEYL HTLEVHSNTL IQLERWFTPT
GQTRVTVVGP LKARLWVMDM IRKVGSKNNL DQIKGKMMLL QIRDHPLRDR DLELHPESGS
SLWITTMNDT TFVEVPHFLR FPLTVAWLFC GFVRILGIHN FADLHW
