ID   KHDC4_CHICK             Reviewed;         619 AA.
AC   Q5ZL54;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=KH homology domain-containing protein 4 {ECO:0000250|UniProtKB:Q7Z7F0};
DE   AltName: Full=Brings lots of money 7 {ECO:0000250|UniProtKB:Q7Z7F0};
DE   AltName: Full=Pre-mRNA splicing factor protein KHDC4;
GN   Name=KHDC4 {ECO:0000250|UniProtKB:Q7Z7F0}; Synonyms=BLOM7;
GN   ORFNames=RCJMB04_7l9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: RNA-binding protein involved in pre-mRNA splicing. Interacts
CC       with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the
CC       spliceosome. Involved in regulating splice site selection. Binds
CC       preferentially RNA with A/C rich sequences and poly-C stretches.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SUBUNIT: Interacts with PRPF19. {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z7F0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- DOMAIN: The C-terminal part is necessary for the interaction with the
CC       PRP19C/Prp19 complex/NTC/Nineteen complex.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- DOMAIN: The KH domains mediate RNA-binding.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SIMILARITY: Belongs to the KHDC4 family. {ECO:0000305}.
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DR   EMBL; AJ719880; CAG31539.1; -; mRNA.
DR   RefSeq; NP_001026499.1; NM_001031328.1.
DR   AlphaFoldDB; Q5ZL54; -.
DR   SMR; Q5ZL54; -.
DR   STRING; 9031.ENSGALP00000023567; -.
DR   PaxDb; Q5ZL54; -.
DR   Ensembl; ENSGALT00000023613; ENSGALP00000023567; ENSGALG00000014652.
DR   GeneID; 425070; -.
DR   KEGG; gga:425070; -.
DR   CTD; 22889; -.
DR   VEuPathDB; HostDB:geneid_425070; -.
DR   eggNOG; KOG1960; Eukaryota.
DR   GeneTree; ENSGT00510000047412; -.
DR   HOGENOM; CLU_032219_1_0_1; -.
DR   InParanoid; Q5ZL54; -.
DR   OMA; MSFCGTQ; -.
DR   PhylomeDB; Q5ZL54; -.
DR   PRO; PR:Q5ZL54; -.
DR   Proteomes; UP000000539; Chromosome 25.
DR   Bgee; ENSGALG00000014652; Expressed in lung and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0006376; P:mRNA splice site selection; ISS:UniProtKB.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR031121; RIK/BLOM7.
DR   PANTHER; PTHR15744; PTHR15744; 1.
DR   SUPFAM; SSF54791; SSF54791; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..619
FT                   /note="KH homology domain-containing protein 4"
FT                   /id="PRO_0000296671"
FT   DOMAIN          110..190
FT                   /note="KH 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   DOMAIN          245..327
FT                   /note="KH 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..554
FT                   /note="Required for nuclear retention"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   REGION          488..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..509
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        588..612
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  65051 MW;  42ACCF102BCBDD62 CRC64;
     MSAGGGGQRD AGTAGGRRSK WDQPGPAPAF LLSGAAPLPG RPFPGGGDGG TAVGVSESSA
     APSGALDAAA AVAAKINAML MAKGKLKPAP NTADKLQALG KGPATNKSKD DLVVAEVEIN
     DVPLTCRNLL TRGQTQDEIS RLSGAAVSTR GRFMTAEEKA KVGPGDRPLY LHVQGQTREL
     VDRAVNRIKE IITNGVVKAA TGSSPTFNGA TVTVYHQPAP ITQMSPAVGQ KPPFQSGMHY
     VQDKLFVGLE HAVPTFNVKE KVEGPGCSYL QHIQIETGAK VFLRGKGSGC IEPASGREAF
     EPMYIYISHP KPEGLAAAKK LCENLLQTVH AEYSRFVNQI TTAVPLAGFA QPAAINSVPS
     QPSYYPSNGY QSGYPVVPPP QQPVQPPYGV PGIVPPAVPM APGVLTTLPT GVPPVPTQYP
     ISQVQPPAST GQSPLSAPFL PAAAPVKTTL PAGTQPQVQP HPQGQKRRFT EELPDERESG
     LLGYQHGPIH MTNLGTGFSS QSEIDGAGSK PASSSGKERE RDRQLMPPPA FPVTGMKSES
     EERNGVGSLP GSHDHQAKKM KTSEKGFGLV AYAGDSSDEE EEHGGHKNAS TFSQGWSLGY
     QYPSSQQRAK QQMPFWMAP