ID   KHDC4_XENLA             Reviewed;         585 AA.
AC   Q2NLB0;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=KH homology domain-containing protein 4;
DE   AltName: Full=Brings lots of money 7 {ECO:0000250|UniProtKB:Q7Z7F0};
DE   AltName: Full=Pre-mRNA splicing factor protein khdc4;
GN   Name=khdc4; Synonyms=blom7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein involved in pre-mRNA splicing. Interacts
CC       with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the
CC       spliceosome. Involved in regulating splice site selection. Binds
CC       preferentially RNA with A/C rich sequences and poly-C stretches.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SUBUNIT: Interacts with PRPF19. {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z7F0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- DOMAIN: The C-terminal part is necessary for the interaction with the
CC       PRP19C/Prp19 complex/NTC/Nineteen complex.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- DOMAIN: The KH domains mediate RNA-binding.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SIMILARITY: Belongs to the KHDC4 family. {ECO:0000305}.
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DR   EMBL; BC110758; AAI10759.1; -; mRNA.
DR   RefSeq; NP_001089931.1; NM_001096462.1.
DR   AlphaFoldDB; Q2NLB0; -.
DR   SMR; Q2NLB0; -.
DR   DNASU; 735000; -.
DR   GeneID; 735000; -.
DR   KEGG; xla:735000; -.
DR   CTD; 735000; -.
DR   Xenbase; XB-GENE-5958036; khdc4.L.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 735000; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0006376; P:mRNA splice site selection; ISS:UniProtKB.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR031121; RIK/BLOM7.
DR   PANTHER; PTHR15744; PTHR15744; 1.
DR   SUPFAM; SSF54791; SSF54791; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..585
FT                   /note="KH homology domain-containing protein 4"
FT                   /id="PRO_0000296673"
FT   DOMAIN          105..185
FT                   /note="KH 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   DOMAIN          240..322
FT                   /note="KH 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   REGION          455..523
FT                   /note="Required for nuclear retention"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   REGION          482..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          543..585
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..577
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   585 AA;  62400 MW;  D73F2DB692E64DEE CRC64;
     MSAGSGRRSK WDQPGPPTTT LLLPGVIPAI IPFTAGAFLS PPEIAAADAT SEAVSAPSGA
     LDAAAAVAAK INAMLVAKGK IKPSQNATEK VHVPGKAPAA AKSKDDLVVA EVEINDVPLT
     CRNLLTRGQT QDEISRMSGA AVSTRGRYMT AEEKAKIGPG DRPLYLHVQG QTRELVDRAV
     NRIKEIITSG VVKAATGSSP TFNGATVTVY HQPAPVTPVV SAAPPKPQFQ SGMHYVQDKL
     FVGLEHAVAT FNVKEKVEGP GCSYLQHIQM ETGAKVFLRG KGSGCIEPAS GREAFEPMYI
     YISHPKPEGL AAAKKLCENL LQTVHAEYNR FVNQITSTAP MTGYAQPPQI SSVSMQPQYY
     PPNGYQTGFP VVQPPAPQPA VQVPYVVSTP IASPVPPPPG VVPNMAAPVP AVPTCYPIPQ
     VQPPGLSLPV PPQGQKRRFT EELPEERDSR LLGYQHGPIH MTNLGTGFLV QSKMDGASVR
     SDTVVVKERE RDRQLMPPPG FPVSAQKEPE EKSAAGTLGV AEDNSIKKLK TSDKTFGLVA
     YAGDSSDEEE DHGVLKNSGW SAGYQYPASQ QQQRPKPQMP FWMAP