ID   KHDC4_XENTR             Reviewed;         612 AA.
AC   A0JM64;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=KH homology domain-containing protein 4;
DE   AltName: Full=Brings lots of money 7 {ECO:0000250|UniProtKB:Q7Z7F0};
DE   AltName: Full=Pre-mRNA splicing factor protein khdc4;
GN   Name=khdc4; Synonyms=blom7;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein involved in pre-mRNA splicing. Interacts
CC       with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the
CC       spliceosome. Involved in regulating splice site selection. Binds
CC       preferentially RNA with A/C rich sequences and poly-C stretches.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SUBUNIT: Interacts with PRPF19. {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z7F0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- DOMAIN: The C-terminal part is necessary for the interaction with the
CC       PRP19C/Prp19 complex/NTC/Nineteen complex.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- DOMAIN: The KH domains mediate RNA-binding.
CC       {ECO:0000250|UniProtKB:Q7Z7F0}.
CC   -!- SIMILARITY: Belongs to the KHDC4 family. {ECO:0000305}.
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DR   EMBL; BC125755; AAI25756.1; -; mRNA.
DR   RefSeq; NP_001072751.1; NM_001079283.1.
DR   AlphaFoldDB; A0JM64; -.
DR   SMR; A0JM64; -.
DR   STRING; 8364.ENSXETP00000027314; -.
DR   DNASU; 780208; -.
DR   Ensembl; ENSXETT00000092027; ENSXETP00000098835; ENSXETG00000037253.
DR   GeneID; 780208; -.
DR   KEGG; xtr:780208; -.
DR   CTD; 22889; -.
DR   Xenbase; XB-GENE-5957982; khdc4.
DR   InParanoid; A0JM64; -.
DR   OrthoDB; 633868at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000037253; Expressed in neurula embryo and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0006376; P:mRNA splice site selection; ISS:UniProtKB.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR031121; RIK/BLOM7.
DR   PANTHER; PTHR15744; PTHR15744; 1.
DR   SUPFAM; SSF54791; SSF54791; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..612
FT                   /note="KH homology domain-containing protein 4"
FT                   /id="PRO_0000296674"
FT   DOMAIN          105..185
FT                   /note="KH 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   DOMAIN          237..319
FT                   /note="KH 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   REGION          477..545
FT                   /note="Required for nuclear retention"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z7F0"
FT   REGION          510..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          565..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        578..604
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   612 AA;  65049 MW;  274421FF37273945 CRC64;
     MSAGSGRRSK WDQPGPPSTT LLLPGVLPAI VPFTAGAFLS PPEMPPVTAT CESVSAPSGA
     LDAAAAVAAK INAMLMAKGK IKPTQNAPEK VQVPGKAPSA AKSKDDLVVA EVEINDVPLT
     CRNLLTRGQT QDEISRMSGA AVSTRGRYMT AEEKAKIGPG DRPLYLHVQG QTRELVDRAV
     NRIKEIITNG VVKAATGSSP TFNGATVTVY HQPAPVAPVA PPKPQFQSGM HYVQDKLFVG
     LEHAVATFNV KEKVEGPGCS YLQHIQLETG AKVFLRGKGS GCIEPASGRE AFEPMYIYIS
     HPKPEGLAAA KKLCENLLQT VHSEYNRFVN QIATTAPLTG YAQPPQIGAV PMQPQYYPPN
     GYQTGFPVVQ QPAPQPAVQV PYVVSTPIGS PVPPLPGVVP TMAAPVPPVP AVPTRYPIPQ
     VQPPGSTVPA QLTAPYMPAP HGKHAAAVVT QAPLQGQKRR FTEELPEERD SGLLGYQHGP
     IHMTNLGTGF PAQSKVDGAT IKSDTMVVKE RERDRQLMPP PGMPVSAQKE PEEKSSPGTV
     GVADDYPVKK LKSSGKTFGL VAYAGDSSDE EEDHGVLKSS GSLSQGWNAG YQYPASQQQQ
     RAKPQMPFWM AP