ID   KHDCL_HUMAN             Reviewed;         128 AA.
AC   Q5JSQ8; E1P535;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Putative KHDC1-like protein;
GN   Name=KHDC1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the KHDC1 family. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction. {ECO:0000305}.
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DR   EMBL; AL365232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48776.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW48777.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW48779.1; -; Genomic_DNA.
DR   EMBL; BC004267; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS47450.1; -.
DR   RefSeq; NP_001119535.1; NM_001126063.2.
DR   AlphaFoldDB; Q5JSQ8; -.
DR   IntAct; Q5JSQ8; 2.
DR   MINT; Q5JSQ8; -.
DR   STRING; 9606.ENSP00000359415; -.
DR   BioMuta; KHDC1L; -.
DR   jPOST; Q5JSQ8; -.
DR   MassIVE; Q5JSQ8; -.
DR   PaxDb; Q5JSQ8; -.
DR   PeptideAtlas; Q5JSQ8; -.
DR   PRIDE; Q5JSQ8; -.
DR   DNASU; 100129128; -.
DR   Ensembl; ENST00000370388.4; ENSP00000359415.3; ENSG00000256980.5.
DR   GeneID; 100129128; -.
DR   KEGG; hsa:100129128; -.
DR   MANE-Select; ENST00000370388.4; ENSP00000359415.3; NM_001126063.3; NP_001119535.1.
DR   UCSC; uc003pgm.5; human.
DR   CTD; 100129128; -.
DR   GeneCards; KHDC1L; -.
DR   HGNC; HGNC:37274; KHDC1L.
DR   HPA; ENSG00000256980; Tissue enhanced (brain, testis).
DR   neXtProt; NX_Q5JSQ8; -.
DR   OpenTargets; ENSG00000256980; -.
DR   PharmGKB; PA165617988; -.
DR   VEuPathDB; HostDB:ENSG00000256980; -.
DR   eggNOG; ENOG502TCCK; Eukaryota.
DR   GeneTree; ENSGT00940000154353; -.
DR   HOGENOM; CLU_102222_1_0_1; -.
DR   InParanoid; Q5JSQ8; -.
DR   OMA; HYSKRHA; -.
DR   OrthoDB; 1594877at2759; -.
DR   PhylomeDB; Q5JSQ8; -.
DR   PathwayCommons; Q5JSQ8; -.
DR   BioGRID-ORCS; 100129128; 13 hits in 1065 CRISPR screens.
DR   GenomeRNAi; 100129128; -.
DR   Pharos; Q5JSQ8; Tdark.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q5JSQ8; protein.
DR   Bgee; ENSG00000256980; Expressed in caudate nucleus and 81 other tissues.
DR   Genevisible; Q5JSQ8; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
DR   CDD; cd12795; FILIA_N_like; 1.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR031952; MOEP19_KH-like.
DR   Pfam; PF16005; MOEP19; 1.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..128
FT                   /note="Putative KHDC1-like protein"
FT                   /id="PRO_0000395326"
SQ   SEQUENCE   128 AA;  14546 MW;  68E0AC61F410DA27 CRC64;
     MAVGTSALSK EPWWTLPENF HSPMVFHMEE DQEELIFGLD DTYLRCIELH SHTLIQLERC
     FTATGQTRVT VVGPPMAKQW LLLMFHCVGS QDSKCHARGL KMLERVRSQP LTNDDLVTSV
     SLPPYTGD