ID   KHDR2_DANRE             Reviewed;         346 AA.
AC   Q08BJ2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=KH domain-containing, RNA-binding, signal transduction-associated protein 2;
GN   Name=khdrbs2; ORFNames=zgc:153588;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that plays a role in the regulation of
CC       alternative splicing. {ECO:0000250|UniProtKB:Q9WU01}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WU01}.
CC   -!- SIMILARITY: Belongs to the KHDRBS family. {ECO:0000305}.
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DR   EMBL; BC124701; AAI24702.1; -; mRNA.
DR   RefSeq; NP_001070758.1; NM_001077290.1.
DR   AlphaFoldDB; Q08BJ2; -.
DR   SMR; Q08BJ2; -.
DR   STRING; 7955.ENSDARP00000091908; -.
DR   PaxDb; Q08BJ2; -.
DR   Ensembl; ENSDART00000101134; ENSDARP00000091908; ENSDARG00000069469.
DR   GeneID; 768147; -.
DR   KEGG; dre:768147; -.
DR   CTD; 202559; -.
DR   ZFIN; ZDB-GENE-061013-497; khdrbs2.
DR   eggNOG; KOG1588; Eukaryota.
DR   GeneTree; ENSGT00940000157134; -.
DR   HOGENOM; CLU_034976_0_0_1; -.
DR   InParanoid; Q08BJ2; -.
DR   OMA; HETYEEY; -.
DR   OrthoDB; 1012406at2759; -.
DR   PhylomeDB; Q08BJ2; -.
DR   TreeFam; TF314878; -.
DR   Reactome; R-DRE-8849468; PTK6 Regulates Proteins Involved in RNA Processing.
DR   PRO; PR:Q08BJ2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000069469; Expressed in brain and 24 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0048024; P:regulation of mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR045071; BBP-like.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR032571; Qua1_dom.
DR   InterPro; IPR032335; Sam68-YY.
DR   PANTHER; PTHR11208; PTHR11208; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF16274; Qua1; 1.
DR   Pfam; PF16568; Sam68-YY; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..346
FT                   /note="KH domain-containing, RNA-binding, signal
FT                   transduction-associated protein 2"
FT                   /id="PRO_0000308956"
FT   DOMAIN          65..131
FT                   /note="KH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   REGION          175..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  38829 MW;  42A78B0E28C7DCE7 CRC64;
     MDQDKYLPEL VAEKESLDAS FVHAMRLLAE EIEKFEGDEL RKDGEVKKYL DIISNKNIKL
     SERVLIPVQQ YPKFNFVGKL LGPRGNSMKR LQEETGAKMS ILGKGSMRDK GKEEELRKSG
     EAKYAHLSND LHVLIEVFAP PGEAYSRMSH ALEEIKKFLV PDYNDEIRQE QLRELSYLNG
     SDDPSRGRSA RGRGLRLTST ASPRGRGSAA PPAPPGRGAA APRGTVSSRT SVPTPARGVS
     APRTRGTAGT PGYRAPSLQA THKTYEDYGY DDGYDGEYDD QSYESYDDNY SNQSKSVSEY
     YEYGHGNNDE NYNNYEEDWI SSRPNLKAPA SRLTRGGYRD HPYGRY