ID   KHDR2_XENTR             Reviewed;         345 AA.
AC   Q0VFL3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=KH domain-containing, RNA-binding, signal transduction-associated protein 2;
GN   Name=khdrbs2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein that plays a role in the regulation of
CC       alternative splicing. {ECO:0000250|UniProtKB:Q9WU01}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WU01}.
CC   -!- SIMILARITY: Belongs to the KHDRBS family. {ECO:0000305}.
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DR   EMBL; BC118787; AAI18788.1; -; mRNA.
DR   RefSeq; NP_001072215.1; NM_001078747.1.
DR   AlphaFoldDB; Q0VFL3; -.
DR   SMR; Q0VFL3; -.
DR   STRING; 8364.ENSXETP00000002264; -.
DR   PaxDb; Q0VFL3; -.
DR   DNASU; 779662; -.
DR   GeneID; 779662; -.
DR   KEGG; xtr:779662; -.
DR   CTD; 202559; -.
DR   Xenbase; XB-GENE-490722; khdrbs2.
DR   eggNOG; KOG1588; Eukaryota.
DR   HOGENOM; CLU_034976_0_0_1; -.
DR   InParanoid; Q0VFL3; -.
DR   OMA; YNNYEEW; -.
DR   OrthoDB; 1012406at2759; -.
DR   PhylomeDB; Q0VFL3; -.
DR   TreeFam; TF314878; -.
DR   Reactome; R-XTR-8849468; PTK6 Regulates Proteins Involved in RNA Processing.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004451; Expressed in brain and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0048024; P:regulation of mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR045071; BBP-like.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR032571; Qua1_dom.
DR   InterPro; IPR032335; Sam68-YY.
DR   PANTHER; PTHR11208; PTHR11208; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   Pfam; PF16274; Qua1; 1.
DR   Pfam; PF16568; Sam68-YY; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..345
FT                   /note="KH domain-containing, RNA-binding, signal
FT                   transduction-associated protein 2"
FT                   /id="PRO_0000308957"
FT   DOMAIN          65..131
FT                   /note="KH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   REGION          178..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  39273 MW;  D1FB13F88BDC690F CRC64;
     MEEEKYLPEL MAEKDSLDPS FVHAMRLLDE EIVKFQDSEG NKEDGEKKYL DIISNKNIKL
     SERVLIPVKQ YPKFNFVGKL LGPRGNSLKR LQEETGAKMS ILGKGSMRDK IKEEELRKSD
     EAKHAHLSDE LHVLLEVFAP PGEAYSRMSH ALEEIKKFLV PDYNDEIRQE QLRELSYLNG
     SDDSERGKGT RGRGIRVPST PSRNRGGVIS PAFPGRGASA TRGAPITRGT ISTVARGIPT
     PRAKAAPTTP GYRLPPPLTI ETYDDYGYDD GFGEDYDEQS YDIYENNYNS QTQSVSEYYD
     YEHGTNEESY NHYEQEEWSK SRSTLKAPLQ RPARAGYREH PYGRY