KHNYN_MOUSE
ID KHNYN_MOUSE Reviewed; 671 AA.
AC Q80U38; Q14B94; Q8BGJ6; Q8C082;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein KHNYN;
DE AltName: Full=KH and NYN domain-containing protein;
GN Name=Khnyn; Synonyms=Kiaa0323;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, Head, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the N4BP1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC27665.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC65529.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK032037; BAC27665.1; ALT_FRAME; mRNA.
DR EMBL; AK033704; BAC28436.1; -; mRNA.
DR EMBL; AK047955; BAC33200.1; -; mRNA.
DR EMBL; AK122247; BAC65529.1; ALT_INIT; Transcribed_RNA.
DR EMBL; BC116260; AAI16261.1; -; mRNA.
DR EMBL; BC116261; AAI16262.1; -; mRNA.
DR CCDS; CCDS27134.1; -.
DR RefSeq; NP_081419.1; NM_027143.3.
DR AlphaFoldDB; Q80U38; -.
DR SMR; Q80U38; -.
DR BioGRID; 230106; 1.
DR STRING; 10090.ENSMUSP00000022831; -.
DR iPTMnet; Q80U38; -.
DR PhosphoSitePlus; Q80U38; -.
DR EPD; Q80U38; -.
DR MaxQB; Q80U38; -.
DR PaxDb; Q80U38; -.
DR PeptideAtlas; Q80U38; -.
DR PRIDE; Q80U38; -.
DR ProteomicsDB; 269298; -.
DR Antibodypedia; 186; 78 antibodies from 16 providers.
DR Ensembl; ENSMUST00000022831; ENSMUSP00000022831; ENSMUSG00000047153.
DR GeneID; 219094; -.
DR KEGG; mmu:219094; -.
DR UCSC; uc007ubb.1; mouse.
DR CTD; 23351; -.
DR MGI; MGI:2451333; Khnyn.
DR VEuPathDB; HostDB:ENSMUSG00000047153; -.
DR eggNOG; KOG3777; Eukaryota.
DR GeneTree; ENSGT00940000161993; -.
DR HOGENOM; CLU_014137_0_0_1; -.
DR InParanoid; Q80U38; -.
DR OMA; NQQQGRE; -.
DR OrthoDB; 771251at2759; -.
DR PhylomeDB; Q80U38; -.
DR TreeFam; TF315783; -.
DR BioGRID-ORCS; 219094; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Khnyn; mouse.
DR PRO; PR:Q80U38; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q80U38; protein.
DR Bgee; ENSMUSG00000047153; Expressed in granulocyte and 217 other tissues.
DR ExpressionAtlas; Q80U38; baseline and differential.
DR Genevisible; Q80U38; MM.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; IBA:GO_Central.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..671
FT /note="Protein KHNYN"
FT /id="PRO_0000084291"
FT DOMAIN 430..582
FT /note="RNase NYN"
FT /evidence="ECO:0000255"
FT REGION 234..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..364
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15037"
FT CONFLICT 106
FT /note="S -> G (in Ref. 1; BAC27665)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="P -> H (in Ref. 1; BAC27665)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 671 AA; 74565 MW; 92071C233535A55A CRC64;
MSTWGFASPT PDRFAVSAEA EDKVREQQTR LERIFNVGMS VLSKDCPENP HIWLQLEGPK
ENVCRAKEYL KGLCSPELQS EIHYPPRLHC IFLGAHGFFL DCLAWSTSAH LVPLLPGSLM
ISGLTEAFVM AQSRVEELVQ RLSWDLQLQS CPGAPDNGGV LRDFSALLQT REDAYTEALL
RLPLAVQEEL LSLVQEASRG QGPSREVGSS GLLSPQFQGV RAPLNEGREF VGTRVAGSGK
SPAVRGQSHT VEKEERKQDA VRDMGSGRKE LSGEEVWEPG VAYRSQLAGG GAEEVAPLKG
KASGKQEVPQ QRGGFSVQGE PSGAHVPCQR AAPIRGASLL QRLHNGSASP PRVPSPPPAP
EPPWPCGDRD RDRDRGDRGD KQQAGARGRG SPWKRGTRGG NLVTGTQRFQ EALQDPFTLC
LANVPGQPDL RHIVIDGSNV AMVHGLQHYF SSRGIALAVQ YFWDRGHRDI TVFVPQWRFS
KDSKVRESHF LQKLYSLSLL SLTPSRVMDG KRISSYDDRF MVKLAEETDG IIVSNDQFRD
LAEESDKWMA IIRERLLPFT FVGNLFMVPD DPLGRNGPTL DEFLKKPVRK QGSSKTQQPS
KGSTEQANQQ QGKDADRSNG GIRKTRETER LRRQLLEVFW GQDHKVDFIL QREPYCRDIN
QLSEALLSLN F
