KHPA_LACPL
ID KHPA_LACPL Reviewed; 85 AA.
AC F9UP09;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=RNA-binding protein KhpA {ECO:0000255|HAMAP-Rule:MF_00088, ECO:0000303|PubMed:30894429};
DE AltName: Full=KH-domain protein A {ECO:0000255|HAMAP-Rule:MF_00088};
GN Name=khpA {ECO:0000255|HAMAP-Rule:MF_00088, ECO:0000303|PubMed:30894429};
GN OrderedLocusNames=lp_1637;
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=22156394; DOI=10.1128/jb.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=30894429; DOI=10.1128/msphere.00007-19;
RA Myrbraaten I.S., Wiull K., Salehian Z., Haavarstein L.S., Straume D.,
RA Mathiesen G., Kjos M.;
RT "CRISPR Interference for Rapid Knockdown of Essential Cell Cycle Genes in
RT Lactobacillus plantarum.";
RL MSphere 4:0-0(2019).
CC -!- FUNCTION: A probable RNA chaperone. Forms a complex with KhpB which
CC binds to cellular RNA and controls its expression. Plays a role in
CC peptidoglycan (PG) homeostasis and cell length regulation.
CC {ECO:0000255|HAMAP-Rule:MF_00088, ECO:0000269|PubMed:30894429}.
CC -!- FUNCTION: Necessary for correct cell elongation.
CC {ECO:0000269|PubMed:30894429}.
CC -!- SUBUNIT: Forms a complex with KhpB. {ECO:0000255|HAMAP-Rule:MF_00088,
CC ECO:0000305|PubMed:30894429}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00088}.
CC -!- DISRUPTION PHENOTYPE: Cell length is reduced.
CC {ECO:0000269|PubMed:30894429}.
CC -!- SIMILARITY: Belongs to the KhpA RNA-binding protein family.
CC {ECO:0000255|HAMAP-Rule:MF_00088}.
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DR EMBL; AL935263; CCC78948.1; -; Genomic_DNA.
DR RefSeq; WP_003640382.1; NC_004567.2.
DR RefSeq; YP_004889462.1; NC_004567.2.
DR STRING; 220668.lp_1637; -.
DR EnsemblBacteria; CCC78948; CCC78948; lp_1637.
DR GeneID; 57025219; -.
DR GeneID; 66449518; -.
DR KEGG; lpl:lp_1637; -.
DR PATRIC; fig|220668.9.peg.1384; -.
DR eggNOG; COG1837; Bacteria.
DR HOGENOM; CLU_132074_1_2_9; -.
DR OMA; HETDEYM; -.
DR PhylomeDB; F9UP09; -.
DR BioCyc; LPLA220668:G1GW0-1411-MON; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.20; -; 1.
DR HAMAP; MF_00088; KhpA; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR020627; KhpA.
DR PANTHER; PTHR34654; PTHR34654; 1.
PE 3: Inferred from homology;
KW Cell shape; Cell wall biogenesis/degradation; Cytoplasm;
KW Reference proteome; RNA-binding.
FT CHAIN 1..85
FT /note="RNA-binding protein KhpA"
FT /id="PRO_0000454537"
FT DOMAIN 32..85
FT /note="KH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00088"
SQ SEQUENCE 85 AA; 9578 MW; 1C52FB5A7E8FE8F9 CRC64;
MADIKALITT VVTPLVQYPD DIKVDFKETT RYLEYNLTVN PEDIGRVIGR QGRVASAIRT
IVYSVRVSGP KRVRLTIEDG QQKNS
