ID   KHPA_MYCTU              Reviewed;          80 AA.
AC   P9WFM7; L0TB00; P67236; Q10826;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=RNA-binding protein KhpA {ECO:0000255|HAMAP-Rule:MF_00088};
DE   AltName: Full=KH-domain protein A {ECO:0000255|HAMAP-Rule:MF_00088};
GN   Name=khpA {ECO:0000255|HAMAP-Rule:MF_00088}; OrderedLocusNames=Rv2908c;
GN   ORFNames=MTCY274.40c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, DETERMINATION OF TRANSLATIONAL START
RP   SITE, AND CLEAVAGE OF INITIATOR METHIONINE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=17259624; DOI=10.1099/mic.0.2006/001537-0;
RA   Rison S.C., Mattow J., Jungblut P.R., Stoker N.G.;
RT   "Experimental determination of translational starts using peptide mass
RT   mapping and tandem mass spectrometry within the proteome of Mycobacterium
RT   tuberculosis.";
RL   Microbiology 153:521-528(2007).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: A probable RNA-binding protein. {ECO:0000255|HAMAP-
CC       Rule:MF_00088}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00088}.
CC   -!- SIMILARITY: Belongs to the KhpA RNA-binding protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_00088}.
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DR   EMBL; AL123456; CCP45710.1; -; Genomic_DNA.
DR   PIR; G70927; G70927.
DR   RefSeq; NP_217424.1; NC_000962.3.
DR   RefSeq; WP_003414728.1; NZ_NVQJ01000006.1.
DR   AlphaFoldDB; P9WFM7; -.
DR   SMR; P9WFM7; -.
DR   STRING; 83332.Rv2908c; -.
DR   PaxDb; P9WFM7; -.
DR   DNASU; 887336; -.
DR   GeneID; 45426895; -.
DR   GeneID; 887336; -.
DR   KEGG; mtu:Rv2908c; -.
DR   TubercuList; Rv2908c; -.
DR   eggNOG; COG1837; Bacteria.
DR   OMA; AVKMDKR; -.
DR   PhylomeDB; P9WFM7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.300.20; -; 1.
DR   HAMAP; MF_00088; KhpA; 1.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR009019; KH_sf_prok-type.
DR   InterPro; IPR020627; KhpA.
DR   PANTHER; PTHR34654; PTHR34654; 1.
DR   SUPFAM; SSF54814; SSF54814; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; RNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:17259624"
FT   CHAIN           2..80
FT                   /note="RNA-binding protein KhpA"
FT                   /id="PRO_0000163231"
FT   DOMAIN          33..80
FT                   /note="KH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00088"
SQ   SEQUENCE   80 AA;  8521 MW;  B3DE2DDF0CF3CEE6 CRC64;
     MSAVVVDAVE HLVRGIVDNP DDVRVDLITS RRGRTVEVHV HPDDLGKVIG RGGRTATALR
     TLVAGIGGRG IRVDVVDTDQ