KHPB_BACSU
ID KHPB_BACSU Reviewed; 208 AA.
AC Q01620;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=RNA-binding protein KhpB {ECO:0000255|HAMAP-Rule:MF_00867};
DE AltName: Full=RNA-binding protein EloR {ECO:0000255|HAMAP-Rule:MF_00867};
GN Name=khpB {ECO:0000255|HAMAP-Rule:MF_00867};
GN Synonyms=eloR {ECO:0000255|HAMAP-Rule:MF_00867},
GN jag {ECO:0000303|PubMed:1487728}; OrderedLocusNames=BSU41030;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=1487728; DOI=10.1099/00221287-138-12-2609;
RA Errington J., Appleby L., Daniel R.A., Goodfellow H., Partridge S.R.,
RA Yudkin M.D.;
RT "Structure and function of the spoIIIJ gene of Bacillus subtilis: a
RT vegetatively expressed gene that is essential for sigma G activity at an
RT intermediate stage of sporulation.";
RL J. Gen. Microbiol. 138:2609-2618(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / CRK2000;
RX PubMed=1552862; DOI=10.1111/j.1365-2958.1992.tb01510.x;
RA Ogasawara N., Yoshikawa H.;
RT "Genes and their organization in the replication origin region of the
RT bacterial chromosome.";
RL Mol. Microbiol. 6:629-634(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=7584024; DOI=10.1093/dnares/1.1.1;
RA Ogasawara N., Nakai S., Yoshikawa H.;
RT "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis
RT chromosome containing the replication origin.";
RL DNA Res. 1:1-14(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: A probable RNA chaperone. Forms a complex with KhpA which
CC binds to cellular RNA and controls its expression. Plays a role in
CC peptidoglycan (PG) homeostasis and cell length regulation.
CC {ECO:0000255|HAMAP-Rule:MF_00867}.
CC -!- SUBUNIT: Forms a complex with KhpA. {ECO:0000255|HAMAP-Rule:MF_00867}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00867}.
CC -!- DOMAIN: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH
CC and R3H). {ECO:0000255|HAMAP-Rule:MF_00867}.
CC -!- SIMILARITY: Belongs to the KhpB RNA-binding protein family.
CC {ECO:0000255|HAMAP-Rule:MF_00867}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z14225; CAA78596.1; -; Genomic_DNA.
DR EMBL; X62539; CAA44402.1; -; Genomic_DNA.
DR EMBL; D26185; BAA05233.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB16140.1; -; Genomic_DNA.
DR PIR; I40438; I40438.
DR RefSeq; NP_391983.1; NC_000964.3.
DR RefSeq; WP_003243764.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; Q01620; -.
DR SMR; Q01620; -.
DR STRING; 224308.BSU41030; -.
DR PaxDb; Q01620; -.
DR PRIDE; Q01620; -.
DR EnsemblBacteria; CAB16140; CAB16140; BSU_41030.
DR GeneID; 937933; -.
DR KEGG; bsu:BSU41030; -.
DR PATRIC; fig|224308.179.peg.4445; -.
DR eggNOG; COG1847; Bacteria.
DR InParanoid; Q01620; -.
DR OMA; MLDIASW; -.
DR PhylomeDB; Q01620; -.
DR BioCyc; BSUB:BSU41030-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR CDD; cd02414; jag_KH; 1.
DR CDD; cd02644; R3H_jag; 1.
DR Gene3D; 3.30.1370.50; -; 1.
DR Gene3D; 3.30.30.80; -; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR HAMAP; MF_00867; KhpB; 1.
DR InterPro; IPR038008; Jag_KH.
DR InterPro; IPR038247; Jag_N_dom_sf.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR039247; KhpB.
DR InterPro; IPR032782; KhpB_N.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034079; R3H_KhpB.
DR PANTHER; PTHR35800; PTHR35800; 1.
DR Pfam; PF14804; Jag_N; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM01245; Jag_N; 1.
DR SMART; SM00322; KH; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF82708; SSF82708; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Cell shape; Cell wall biogenesis/degradation; Chaperone; Cytoplasm;
KW Reference proteome; RNA-binding.
FT CHAIN 1..208
FT /note="RNA-binding protein KhpB"
FT /id="PRO_0000084279"
FT DOMAIN 58..135
FT /note="KH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00867"
FT DOMAIN 140..208
FT /note="R3H"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00867"
FT REGION 5..55
FT /note="Jag_N domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00867"
SQ SEQUENCE 208 AA; 23162 MW; A36657E594E0BE14 CRC64;
MRNVTAAGRN VDEAVQSGLQ ELGLTKDKVE ITVIEEGNKG FLGIFGKKPA IVKLVEKIDP
IQQAKLYLQT IAEAIAGKSD VTVQESKKTV RYHITGEKAA LLIGKRGQTL NALETLTQLA
LNRYPGQYKN VTVDAENYRL KRKETLSQLA IKLADQVLKT KKSIQLEPMP SSERKIIHDT
LSGYANHQIK TYSMGEGENR HLVISHKR
