KHSE_BRASB
ID KHSE_BRASB Reviewed; 326 AA.
AC A5EAL1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Homoserine kinase {ECO:0000255|HAMAP-Rule:MF_00301};
DE Short=HK {ECO:0000255|HAMAP-Rule:MF_00301};
DE Short=HSK {ECO:0000255|HAMAP-Rule:MF_00301};
DE EC=2.7.1.39 {ECO:0000255|HAMAP-Rule:MF_00301};
GN Name=thrB {ECO:0000255|HAMAP-Rule:MF_00301}; OrderedLocusNames=BBta_0949;
OS Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX NCBI_TaxID=288000;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTAi1 / ATCC BAA-1182;
RX PubMed=17540897; DOI=10.1126/science.1139548;
RA Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL Science 316:1307-1312(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC EC=2.7.1.39; Evidence={ECO:0000255|HAMAP-Rule:MF_00301};
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 4/5. {ECO:0000255|HAMAP-Rule:MF_00301}.
CC -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC {ECO:0000255|HAMAP-Rule:MF_00301}.
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DR EMBL; CP000494; ABQ33205.1; -; Genomic_DNA.
DR RefSeq; WP_012041253.1; NC_009485.1.
DR AlphaFoldDB; A5EAL1; -.
DR SMR; A5EAL1; -.
DR STRING; 288000.BBta_0949; -.
DR EnsemblBacteria; ABQ33205; ABQ33205; BBta_0949.
DR KEGG; bbt:BBta_0949; -.
DR eggNOG; COG2334; Bacteria.
DR HOGENOM; CLU_053300_1_0_5; -.
DR OMA; DPTHFER; -.
DR OrthoDB; 1003984at2; -.
DR UniPathway; UPA00050; UER00064.
DR Proteomes; UP000000246; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd05153; HomoserineK_II; 1.
DR HAMAP; MF_00301; Homoser_kinase_2; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR005280; Homoserine_kinase_II.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR TIGRFAMs; TIGR00938; thrB_alt; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Kinase; Nucleotide-binding;
KW Threonine biosynthesis; Transferase.
FT CHAIN 1..326
FT /note="Homoserine kinase"
FT /id="PRO_0000300780"
SQ SEQUENCE 326 AA; 35641 MW; 6375334C136CF0E4 CRC64;
MAVYTDVAAD ELADFLKTYD IGELLSYKGI AEGVENSNFL LHTTKGYFIL TLYEKRVAVD
DLPYFLGLMA HLAERGVSCP QPARNRDGAV YSTLSGRPAA IINFLEGLWP RKPNVAHCAG
VGTALARMHL AGRDFPLVRK NPLSVSGWMS LFAQAADRAD TVQAGLSALL SAELDVLARS
WPTDLPEGVI HADLFPDNVF FLGDQLSGLI DFPFSCNDIL AYDVAICLNA WCFEADHSLN
VTKARAFFHA YGRERPLSQA ELAALPLLAR GAAIRFLLTR LVDWLNVPAG ALVKPKDPLE
YVRKLRFHQA VTSVRDYGLD GSGATA
