ID   KHSE_CAUVN              Reviewed;         317 AA.
AC   B8H4W6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Homoserine kinase {ECO:0000255|HAMAP-Rule:MF_00301};
DE            Short=HK {ECO:0000255|HAMAP-Rule:MF_00301};
DE            Short=HSK {ECO:0000255|HAMAP-Rule:MF_00301};
DE            EC=2.7.1.39 {ECO:0000255|HAMAP-Rule:MF_00301};
GN   Name=thrB {ECO:0000255|HAMAP-Rule:MF_00301}; OrderedLocusNames=CCNA_03475;
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39; Evidence={ECO:0000255|HAMAP-Rule:MF_00301};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 4/5. {ECO:0000255|HAMAP-Rule:MF_00301}.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00301}.
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DR   EMBL; CP001340; ACL96940.1; -; Genomic_DNA.
DR   RefSeq; WP_010921193.1; NC_011916.1.
DR   RefSeq; YP_002518848.1; NC_011916.1.
DR   AlphaFoldDB; B8H4W6; -.
DR   SMR; B8H4W6; -.
DR   PRIDE; B8H4W6; -.
DR   EnsemblBacteria; ACL96940; ACL96940; CCNA_03475.
DR   GeneID; 7332472; -.
DR   KEGG; ccs:CCNA_03475; -.
DR   PATRIC; fig|565050.3.peg.3389; -.
DR   HOGENOM; CLU_053300_1_0_5; -.
DR   OMA; DPTHFER; -.
DR   OrthoDB; 1003984at2; -.
DR   PhylomeDB; B8H4W6; -.
DR   UniPathway; UPA00050; UER00064.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05153; HomoserineK_II; 1.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_II.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00938; thrB_alt; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Kinase; Nucleotide-binding;
KW   Reference proteome; Threonine biosynthesis; Transferase.
FT   CHAIN           1..317
FT                   /note="Homoserine kinase"
FT                   /id="PRO_1000196944"
SQ   SEQUENCE   317 AA;  35025 MW;  97C9304EB6508C8A CRC64;
     MAVYTDITDQ ELEAFLEGYD LGAPLAFKGI AEGVENSNFL LETEKGRYIL TVYERRVKAE
     DLPYFLNMLT WLADRGYPSA RPIPTRSGAT LSSLRGKPAA IVEFLPGLSV RKPTAAHCRE
     AGEGLAWLHL AGEGYPGRRA NDLGQAAWSP LFSKHRKAAE DLKPGLSATI DNDLAQLSLM
     WPRNLPTGTI HADYFPDNVF FQSNGKFAAA IDFYFACDDA YAYDVAVTLN AWCFEADGSF
     NITAAKALLN GYERRRPLSP IEKEALPILA RGAAMRFFLT RLADWGSTPA GALVRPKDPL
     EYERKLAVHR EGLVLFA