ARAB_ALKHC
ID ARAB_ALKHC Reviewed; 563 AA.
AC Q9KBQ3;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Ribulokinase {ECO:0000255|HAMAP-Rule:MF_00520};
DE EC=2.7.1.16 {ECO:0000255|HAMAP-Rule:MF_00520};
GN Name=araB {ECO:0000255|HAMAP-Rule:MF_00520}; OrderedLocusNames=BH1872;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+);
CC Xref=Rhea:RHEA:17601, ChEBI:CHEBI:15378, ChEBI:CHEBI:17173,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58121, ChEBI:CHEBI:456216;
CC EC=2.7.1.16; Evidence={ECO:0000255|HAMAP-Rule:MF_00520};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:22072, ChEBI:CHEBI:15378, ChEBI:CHEBI:16880,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58226, ChEBI:CHEBI:456216;
CC EC=2.7.1.16; Evidence={ECO:0000255|HAMAP-Rule:MF_00520};
CC -!- PATHWAY: Carbohydrate degradation; L-arabinose degradation via L-
CC ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route):
CC step 2/3. {ECO:0000255|HAMAP-Rule:MF_00520}.
CC -!- SIMILARITY: Belongs to the ribulokinase family. {ECO:0000255|HAMAP-
CC Rule:MF_00520}.
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DR EMBL; BA000004; BAB05591.1; -; Genomic_DNA.
DR PIR; H83883; H83883.
DR RefSeq; WP_010898033.1; NC_002570.2.
DR PDB; 3QDK; X-ray; 2.31 A; A/B/C/D=3-563.
DR PDBsum; 3QDK; -.
DR AlphaFoldDB; Q9KBQ3; -.
DR SMR; Q9KBQ3; -.
DR STRING; 272558.10174490; -.
DR EnsemblBacteria; BAB05591; BAB05591; BAB05591.
DR KEGG; bha:BH1872; -.
DR eggNOG; COG1069; Bacteria.
DR HOGENOM; CLU_009281_9_1_9; -.
DR OMA; GHKAMWH; -.
DR OrthoDB; 1619686at2; -.
DR BRENDA; 2.7.1.16; 661.
DR UniPathway; UPA00145; UER00566.
DR EvolutionaryTrace; Q9KBQ3; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019150; F:D-ribulokinase activity; IEA:RHEA.
DR GO; GO:0008741; F:ribulokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019569; P:L-arabinose catabolic process to xylulose 5-phosphate; IEA:UniProtKB-UniRule.
DR CDD; cd07781; FGGY_RBK; 1.
DR HAMAP; MF_00520; Ribulokinase; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR005929; Ribulokinase.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR01234; L-ribulokinase; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Arabinose catabolism; ATP-binding; Carbohydrate metabolism;
KW Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..563
FT /note="Ribulokinase"
FT /id="PRO_0000198354"
FT STRAND 5..11
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 13..22
FT /evidence="ECO:0007829|PDB:3QDK"
FT TURN 23..25
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 28..35
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 41..45
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 61..77
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 86..93
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 98..101
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 108..110
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 114..116
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 118..120
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 121..123
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 131..144
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 149..152
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 161..171
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 173..178
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 180..184
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 185..194
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 201..207
FT /evidence="ECO:0007829|PDB:3QDK"
FT TURN 212..214
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 219..223
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 227..229
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 232..234
FT /evidence="ECO:0007829|PDB:3QDK"
FT TURN 235..237
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 246..250
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 253..259
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 266..268
FT /evidence="ECO:0007829|PDB:3QDK"
FT TURN 273..276
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 277..280
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 287..305
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 313..317
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 319..321
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 324..332
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 335..344
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 348..356
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 361..369
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 380..382
FT /evidence="ECO:0007829|PDB:3QDK"
FT TURN 390..392
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 394..396
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 399..404
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 410..433
FT /evidence="ECO:0007829|PDB:3QDK"
FT TURN 434..436
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 439..447
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 448..451
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 453..463
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 467..470
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 475..488
FT /evidence="ECO:0007829|PDB:3QDK"
FT TURN 490..493
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 498..505
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 517..538
FT /evidence="ECO:0007829|PDB:3QDK"
FT STRAND 539..541
FT /evidence="ECO:0007829|PDB:3QDK"
FT HELIX 544..551
FT /evidence="ECO:0007829|PDB:3QDK"
SQ SEQUENCE 563 AA; 61668 MW; CCBC399006669ACD CRC64;
MTTKYTIGVD YGTESGRAVL IDLSNGQELA DHVTPYRHGV IDQYLPNTNI KLGHEWALQH
PLDYVEVLTT SVPAVMKESG VDADDVIGIG VDFTACTMLP VDEEGQPLCL LAQYKDNPHS
WVKLWKHHAA QDKANAINEM AEKRGEAFLP RYGGKISSEW MIAKVWQILD EAEDVYNRTD
QFLEATDWIV SQMTGKIVKN SCTAGYKAIW HKREGYPSNE FFKALDPRLE HLTTTKLRGD
IVPLGERAGG LLPEMAEKMG LNPGIAVAVG NVDAHAAVPA VGVTTPGKLV MAMGTSICHM
LLGEKEQEVE GMCGVVEDGI IPGYLGYEAG QSAVGDIFAW FVKHGVSAAT FDEAQEKGVN
VHALLEEKAS QLRPGESGLL ALDWWNGNRS ILVDTELSGM LLGYTLQTKP EEIYRALLEA
TAFGTRAIVD AFHGRGVEVH ELYACGGLPQ KNHLLMQIFA DVTNREIKVA ASKQTPALGA
AMFASVAAGS EVGGYDSIEE AAKKMGRVKD ETFKPIPEHV AIYEKLYQEY VTLHDYFGRG
ANDVMKRLKA LKSIQHRPSS LLT
