KHSE_METGL
ID KHSE_METGL Reviewed; 318 AA.
AC O32378;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Homoserine kinase;
DE Short=HK;
DE Short=HSK;
DE EC=2.7.1.39;
GN Name=thrB;
OS Methylobacillus glycogenes.
OC Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylobacillus.
OX NCBI_TaxID=406;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATR80;
RA Motoyama H., Anazawa H., Ishino S., Teshiba S.;
RT "Production of l-threonine by fermentation method.";
RL Patent number JP1993207886, 20-AUG-1993.
RN [2]
RP IDENTIFICATION OF PROBABLE FRAMESHIFTS.
RA Bairoch A.;
RL Unpublished observations (DEC-2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC EC=2.7.1.39;
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC from L-aspartate: step 4/5.
CC -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA21850.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; D14072; BAA21850.1; ALT_FRAME; Genomic_DNA.
DR UniPathway; UPA00050; UER00064.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd05153; HomoserineK_II; 1.
DR HAMAP; MF_00301; Homoser_kinase_2; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR005280; Homoserine_kinase_II.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR TIGRFAMs; TIGR00938; thrB_alt; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Kinase; Nucleotide-binding;
KW Threonine biosynthesis; Transferase.
FT CHAIN 1..318
FT /note="Homoserine kinase"
FT /id="PRO_0000172191"
SQ SEQUENCE 318 AA; 35622 MW; B3C23E33176E81C9 CRC64;
MSVFTAVSFE QMQQWLKGYD LGELLDLQGI ASGITNTNYF VATGTGRYVL TLFEEHSAEE
LPNFLDLMTH LAERGIPCPY PVKNIAGQAL GELNGKPAAL VSCLAGKSLD NPSPQHCAAI
GEVLARMHLA GASFEVSIIN LRCQRWRIAR LPRWAPFLDA ENXRMLDAQL EFEQAFDTSA
LSRGVIHADL FRDNVLMDGD KVGGVLDFYY AWNDVLFYDI AIAVXDWCVN ADGTRDVGRV
RAFLDAYHAV RPLTEEEHAA WPGMLRVAGI RFWLSRLNDL HFPQAGELIH AKDPAYFERI
LRKAIAAREQ LLTMWVDS