ID   KHSE_RHOPA              Reviewed;         327 AA.
AC   Q6N1Y2;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Homoserine kinase {ECO:0000255|HAMAP-Rule:MF_00301};
DE            Short=HK {ECO:0000255|HAMAP-Rule:MF_00301};
DE            Short=HSK {ECO:0000255|HAMAP-Rule:MF_00301};
DE            EC=2.7.1.39 {ECO:0000255|HAMAP-Rule:MF_00301};
GN   Name=thrB {ECO:0000255|HAMAP-Rule:MF_00301}; OrderedLocusNames=RPA4270;
OS   Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=258594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-98 / CGA009;
RX   PubMed=14704707; DOI=10.1038/nbt923;
RA   Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L.,
RA   Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R.,
RA   Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C.,
RA   Harrison F.H., Gibson J., Harwood C.S.;
RT   "Complete genome sequence of the metabolically versatile photosynthetic
RT   bacterium Rhodopseudomonas palustris.";
RL   Nat. Biotechnol. 22:55-61(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39; Evidence={ECO:0000255|HAMAP-Rule:MF_00301};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 4/5. {ECO:0000255|HAMAP-Rule:MF_00301}.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00301}.
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DR   EMBL; BX572606; CAE29711.1; -; Genomic_DNA.
DR   RefSeq; WP_011159805.1; NC_005296.1.
DR   AlphaFoldDB; Q6N1Y2; -.
DR   SMR; Q6N1Y2; -.
DR   STRING; 258594.RPA4270; -.
DR   PRIDE; Q6N1Y2; -.
DR   EnsemblBacteria; CAE29711; CAE29711; RPA4270.
DR   GeneID; 66895396; -.
DR   KEGG; rpa:RPA4270; -.
DR   eggNOG; COG2334; Bacteria.
DR   HOGENOM; CLU_053300_1_0_5; -.
DR   OMA; DPTHFER; -.
DR   PhylomeDB; Q6N1Y2; -.
DR   BioCyc; RPAL258594:TX73_RS21775-MON; -.
DR   UniPathway; UPA00050; UER00064.
DR   Proteomes; UP000001426; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05153; HomoserineK_II; 1.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_II.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00938; thrB_alt; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Kinase; Nucleotide-binding;
KW   Reference proteome; Threonine biosynthesis; Transferase.
FT   CHAIN           1..327
FT                   /note="Homoserine kinase"
FT                   /id="PRO_0000172198"
SQ   SEQUENCE   327 AA;  35821 MW;  6574668FDE5BAD81 CRC64;
     MAVYTDVAAD ELADFLSRYD IGDLLSYKGI AEGVENSNFL LHTSRGYFIL TLYEKRVARD
     DLPFFLSLMT HLADSGINCP QPVADREGRT LATLAGRPAA IISFLDGVWP RKPSVVHCAG
     VGQALAKMHL AGRDFAMKRA NALSVAGWRP LFAAAEARAD EVQPGLRDFL AAELSYLESG
     VWPSDLPQGL IHADLFPDNV FFIGDEVSGI IDFTFACNDL LAYDVAICLN AWCFEADHAF
     NVTKARALLS AYTRERPLDA AEQAALPLLA RGAALRFLLT RLVDWLNVPE GALVKPKDPM
     EYVRKLRFQQ NVAGIRDYGV EIAGAVA