ID   KHSE_ZYMMO              Reviewed;         320 AA.
AC   O69015; Q5NM36;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Homoserine kinase {ECO:0000255|HAMAP-Rule:MF_00301};
DE            Short=HK {ECO:0000255|HAMAP-Rule:MF_00301};
DE            Short=HSK {ECO:0000255|HAMAP-Rule:MF_00301};
DE            EC=2.7.1.39 {ECO:0000255|HAMAP-Rule:MF_00301};
GN   Name=thrB {ECO:0000255|HAMAP-Rule:MF_00301}; OrderedLocusNames=ZMO1600;
OS   Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Zymomonadaceae; Zymomonas.
OX   NCBI_TaxID=264203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RA   Lee J., Jin S., Kang H.S.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   PubMed=15592456; DOI=10.1038/nbt1045;
RA   Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA   Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA   Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA   Kang H.S.;
RT   "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT   ZM4.";
RL   Nat. Biotechnol. 23:63-68(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39; Evidence={ECO:0000255|HAMAP-Rule:MF_00301};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine
CC       from L-aspartate: step 4/5. {ECO:0000255|HAMAP-Rule:MF_00301}.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00301}.
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DR   EMBL; AF086791; AAC70365.1; -; Genomic_DNA.
DR   EMBL; AE008692; AAV90224.1; -; Genomic_DNA.
DR   PIR; T33726; T33726.
DR   RefSeq; WP_011241354.1; NZ_CP035711.1.
DR   AlphaFoldDB; O69015; -.
DR   SMR; O69015; -.
DR   STRING; 264203.ZMO1600; -.
DR   EnsemblBacteria; AAV90224; AAV90224; ZMO1600.
DR   GeneID; 58027319; -.
DR   KEGG; zmo:ZMO1600; -.
DR   eggNOG; COG2334; Bacteria.
DR   HOGENOM; CLU_053300_1_0_5; -.
DR   OMA; DPTHFER; -.
DR   OrthoDB; 1003984at2; -.
DR   UniPathway; UPA00050; UER00064.
DR   Proteomes; UP000001173; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05153; HomoserineK_II; 1.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_II.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00938; thrB_alt; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Kinase; Nucleotide-binding;
KW   Reference proteome; Threonine biosynthesis; Transferase.
FT   CHAIN           1..320
FT                   /note="Homoserine kinase"
FT                   /id="PRO_0000172199"
FT   CONFLICT        109..127
FT                   /note="RWTPTPNAEQTRATGEMLG -> VGRPPLMRNRPVLPVKCWV (in Ref.
FT                   1; AAC70365)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   320 AA;  36738 MW;  A83813C635812EF0 CRC64;
     MAVYTSVSDE EVSSFLDLYP DSGRLLSIKG ITEGVENSNY LITTDVRSYI LTLYEKRVNP
     EELPFFMALT DHLAAENLPV PKAWKSRDGK QIQTLAGRPA CLIEFLQGRW TPTPNAEQTR
     ATGEMLGKMH KSLTHFSENR KNSLDLENWH ILAEKCGFEA MNQIEAHMGD EVKKELDYLD
     KFWPKDLPRS VIHADLFPDN VLFEGDSLKG VIDFYFACTE VRAWDLAITY SAWCFDQEDH
     FLADHAKALI KGYHQSFALT EEERAAFIVL LRGAALRFLL TRAWDWVNTP PDALVVPKDP
     RDFFKRLRFY REASLESLGF