KHT2_KLULC
ID KHT2_KLULC Reviewed; 566 AA.
AC P53387;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Hexose transporter 2;
GN Name=KHT2;
OS Kluyveromyces lactis (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=28985;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96263 / JA6;
RX PubMed=9363776; DOI=10.1111/j.1432-1033.1997.t01-1-00248.x;
RA Weirich J., Goffrini P., Kuger P., Ferrero I., Breunig K.D.;
RT "Influence of mutations in hexose-transporter genes on glucose repression
RT in Kluyveromyces lactis.";
RL Eur. J. Biochem. 249:248-257(1997).
CC -!- FUNCTION: Probable glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; Z47080; CAA87389.1; -; Genomic_DNA.
DR PIR; S51081; S51081.
DR AlphaFoldDB; P53387; -.
DR SMR; P53387; -.
DR VEuPathDB; FungiDB:KLLA0_D13310g; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Repeat; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..566
FT /note="Hexose transporter 2"
FT /id="PRO_0000050420"
FT TOPO_DOM 22..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..166
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..353
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..357
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379..385
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 407..428
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..465
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 487..492
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 514..566
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 566 AA; 62728 MW; 9784173EC2375444 CRC64;
MSELETGTAA HGTPVENKSV SSSQASTPTN VGSRDDLKVD DDNHSVDAIE LPKKPRSAYI
TVSILCLMVA FGGFVFGWDT GTISGFVNQT DFIRRFGQEK ADGSHYLSNV RTGLIVSIFN
IGCAIGGIIL SKLGDMYGRR IGLMIVVLIY VVGIIIQIAS IDKWYQYFIG RIISGLGVGG
ISVLSPMLIS ETAPKHIRGT LVSFYQLMIT FGIFLGYCTN YGTKTYSNSV QWRVPLGLCF
AWAIFMITGM LFVPESPRFL VEKDRIDEAK RSIAKSNKVS YEDPAVQAEV DLICAGVEAE
RLAGSASIKE LFSTKTKVFQ RLIMGMLIQS FQQLTGNNYF FYYGTTIFNS VGMDDSFETS
IVLGIVNFAS TFVAIYVVDK FGRRKCLLWG AAAMTACMVV FASVGVTRLW PDGANHPETA
SKGAGNCMIV FACFYIFCFA TSWAPIAYVV VAESYPLRVK AKCMAIATAS NWIWGFLNGF
FTPFITSAIH FYYGYVFMGC LVAMFFYVFF FVPETKGLTL EEVQEMWEEG VLPWKSSSWV
PSSRRNAGYD VDALQHDEKP WYKAML
