KI26L_DROME
ID KI26L_DROME Reviewed; 1131 AA.
AC Q9VLW2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Kinesin-like protein CG14535;
GN ORFNames=CG14535;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIF26 subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00283}.
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DR EMBL; AE014134; AAF52569.2; -; Genomic_DNA.
DR EMBL; BT029102; ABJ17035.1; -; mRNA.
DR RefSeq; NP_001285726.1; NM_001298797.1.
DR RefSeq; NP_609156.1; NM_135312.2.
DR AlphaFoldDB; Q9VLW2; -.
DR SMR; Q9VLW2; -.
DR IntAct; Q9VLW2; 10.
DR STRING; 7227.FBpp0079186; -.
DR PaxDb; Q9VLW2; -.
DR DNASU; 34073; -.
DR EnsemblMetazoa; FBtr0079564; FBpp0079186; FBgn0031955.
DR EnsemblMetazoa; FBtr0343421; FBpp0310067; FBgn0031955.
DR GeneID; 34073; -.
DR KEGG; dme:Dmel_CG14535; -.
DR UCSC; CG14535-RA; d. melanogaster.
DR FlyBase; FBgn0031955; CG14535.
DR VEuPathDB; VectorBase:FBgn0031955; -.
DR eggNOG; KOG4280; Eukaryota.
DR HOGENOM; CLU_008498_0_0_1; -.
DR InParanoid; Q9VLW2; -.
DR OMA; KQSDVCA; -.
DR OrthoDB; 109126at2759; -.
DR PhylomeDB; Q9VLW2; -.
DR Reactome; R-DME-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-DME-983189; Kinesins.
DR BioGRID-ORCS; 34073; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 34073; -.
DR PRO; PR:Q9VLW2; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031955; Expressed in central nervous system and 4 other tissues.
DR ExpressionAtlas; Q9VLW2; baseline and differential.
DR Genevisible; Q9VLW2; DM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; ISS:FlyBase.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; PTHR24115; 2.
DR Pfam; PF00225; Kinesin; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Cytoskeleton; Microtubule; Motor protein;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..1131
FT /note="Kinesin-like protein CG14535"
FT /id="PRO_0000307303"
FT DOMAIN 44..396
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1131 AA; 120722 MW; CB8413CD0F79466C CRC64;
MATTSTSNMS RNGGFCGALQ RAPPPMPPTL IRRLSSRECY GVGKVKVMLR VADRDRNSGG
TEPDFMALDK KKRQVTLTDP RTACPPPQAA QERAPMVAAP KMFAFDNLFT GEDKQSDVCA
SALSEVIPAV LEGSDGCLLA MGYPATGQAQ TVLGELGGGS GSGSASGSGV ACSLGAAPCA
IAWLYKGIQE RRQKSGARFS VRVSAVGVSA TKPDALSQDL LISHAAESDD SPGIYLRDDF
LGGPTELRAP TAERAALFLD SALAGRLKSS GSTASGSSGC AAPLESALIF TLHVYQYSLS
RKGGVAGGRS RLHIIDLGGC ANRNGGLPLS GIGNILLAIL SGQRHPPHKD HPLTPLLKDC
LAPITCHVAI VAHVRPEQSY QDALSTIQIA SRIHRLRRRK HRVPMPLAVG LAQGLGGNGS
SAGSGADPSS SEISADTVIY MGPNDDATDG EHPPVYLPSL TAGDNRGVMS KALKGSGLEK
PPSKSASNSP MMMKKAMAAE KAKKLPGSHT GSLKRQAGAG ACSSPMIPHE QPQIQAMGSP
IPIPRHMVSK GSMVPSPKGS PMRRAHPGAA LEQLEAGMRK ITEEQWIDGP RVSRAKVAEA
RHLMREVNHV KQCETWVDGP KSQSCRSLTA CNLPAAGGSQ TQGYGFMDAH KKTMIRQWVE
NQTTQVFQST VSASNSPTAL HWKLSQLKQK SLDLPDRPAF NPEPSLDLNQ PCFESLPLLD
PAPPDGDEDE DSGPSEVPPA LPLLDDPLGS RDISQDNLHR MLSRHVSREQ LHEAELVASR
ASSSHHPSQR SIDCGLQVTE EEIARTMSRD RDHDPSAHPL SALSHCDNIS FVSSFNMACE
SFSECGERAR QQFDQLARLH EIFTSQLAMA EVTPSAALFR TDIGSVFSEP VYHFNVGQSS
VCSEPAYRLT PSPPKQPSHS PSQGSLPSLN GIMEIAGMDD YALLRQPDGA SDPNLQKGEK
RFTPQHDDIC ELDEKSMAAA VGKGNSLEDA QHKLNEITNI LPLAAQSRLP LLPLNTSSEA
YDSGHDSNST PRTSKHSGIS RRAESGYHSV ATVRDSDESS FASGMSKGQR HRITVSGTGA
VTSAGIGNYQ RQCHKKRHRQ DQAGNNKGLC NWLLTPFSCT YPETEGEISD F
