KI2LA_HUMAN
ID KI2LA_HUMAN Reviewed; 375 AA.
AC Q8N109;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Killer cell immunoglobulin-like receptor 2DL5A;
DE AltName: CD_antigen=CD158f1;
DE Flags: Precursor;
GN Name=KIR2DL5A; Synonyms=CD158F, CD158F1, KIR2DL5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP GENE FAMILY.
RX PubMed=12185535; DOI=10.1007/s00251-002-0476-2;
RA Gomez-Lozano N., Gardiner C.M., Parham P., Vilches C.;
RT "Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and
RT KIR2DL5B.";
RL Immunogenetics 54:314-319(2002).
CC -!- FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles.
CC Inhibits the activity of NK cells thus preventing cell lysis.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR EMBL; AL133414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_065396.1; NM_020535.3.
DR AlphaFoldDB; Q8N109; -.
DR SMR; Q8N109; -.
DR BioGRID; 110007; 2.
DR GlyGen; Q8N109; 3 sites.
DR iPTMnet; Q8N109; -.
DR PhosphoSitePlus; Q8N109; -.
DR BioMuta; KIR2DL5A; -.
DR DMDM; 74759760; -.
DR MassIVE; Q8N109; -.
DR PeptideAtlas; Q8N109; -.
DR PRIDE; Q8N109; -.
DR DNASU; 57292; -.
DR Ensembl; ENST00000611422.1; ENSP00000479384.1; ENSG00000274676.1.
DR Ensembl; ENST00000612730.1; ENSP00000483324.1; ENSG00000274143.1.
DR Ensembl; ENST00000613155.1; ENSP00000484296.1; ENSG00000275596.1.
DR GeneID; 57292; -.
DR KEGG; hsa:57292; -.
DR UCSC; uc032ivi.2; human.
DR CTD; 57292; -.
DR DisGeNET; 57292; -.
DR GeneCards; KIR2DL5A; -.
DR HGNC; HGNC:16345; KIR2DL5A.
DR MIM; 605305; gene.
DR neXtProt; NX_Q8N109; -.
DR OpenTargets; ENSG00000274143; -.
DR PharmGKB; PA142671590; -.
DR InParanoid; Q8N109; -.
DR OrthoDB; 1055520at2759; -.
DR PathwayCommons; Q8N109; -.
DR SignaLink; Q8N109; -.
DR BioGRID-ORCS; 57292; 1 hit in 27 CRISPR screens.
DR GenomeRNAi; 57292; -.
DR Pharos; Q8N109; Tdark.
DR PRO; PR:Q8N109; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N109; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..375
FT /note="Killer cell immunoglobulin-like receptor 2DL5A"
FT /id="PRO_0000300638"
FT TOPO_DOM 22..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..102
FT /note="Ig-like C2-type 1"
FT DOMAIN 137..200
FT /note="Ig-like C2-type 2"
FT REGION 213..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..95
FT /evidence="ECO:0000250"
FT DISULFID 144..193
FT /evidence="ECO:0000250"
SQ SEQUENCE 375 AA; 40678 MW; 84B53DFCEE473293 CRC64;
MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL
YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL
FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVNGTFQADF
PLGPATHGGT YTCFGSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH
ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ
LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL
SQNRVASSHV PAAGI
