KI2LB_HUMAN
ID KI2LB_HUMAN Reviewed; 375 AA.
AC Q8NHK3; B0L651; Q8NHK4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Killer cell immunoglobulin-like receptor 2DL5B;
DE AltName: Full=CD158 antigen-like family member F2;
DE AltName: Full=Killer cell immunoglobulin-like receptor 2DLX;
DE AltName: CD_antigen=CD158f2;
DE Flags: Precursor;
GN Name=KIR2DL5B; Synonyms=CD158F, CD158F2, KIR2DL5, KIR2DLX;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=18461314; DOI=10.1007/s00251-008-0273-7;
RA Mulrooney T.J., Hou L., Steiner N.K., Chen M., Belle I., Ng J.,
RA Hurley C.K.;
RT "Promoter variants of KIR2DL5 add to diversity and may impact gene
RT expression.";
RL Immunogenetics 60:287-294(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=21206914; DOI=10.1371/journal.pone.0015115;
RA Pyo C.W., Guethlein L.A., Vu Q., Wang R., Abi-Rached L., Norman P.J.,
RA Marsh S.G., Miller J.S., Parham P., Geraghty D.E.;
RT "Different patterns of evolution in the centromeric and telomeric regions
RT of group A and B haplotypes of the human killer cell Ig-like receptor
RT locus.";
RL PLoS ONE 5:E15115-E15115(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=23394822; DOI=10.1186/1471-2164-14-89;
RA Pyo C.W., Wang R., Vu Q., Cereb N., Yang S.Y., Duh F.M., Wolinsky S.,
RA Martin M.P., Carrington M., Geraghty D.E.;
RT "Recombinant structures expand and contract inter and intragenic
RT diversification at the KIR locus.";
RL BMC Genomics 14:89-89(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS ILE-6; ALA-141 AND
RP GLY-276.
RA Selvakumar A., Dupont B.;
RT "KIR2DLX is a member of a KIR gene family encoding both activating and
RT inhibiting receptor genes.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nemat-Gorgani N., Norman P.J., Parham P.;
RT "KIR Diversity in Africans.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Roe D., Vierra-Green C., Pyo C.-W., Eng K., Hall R., Spellman S.,
RA Ranade S., Geraghty D.E., Maiers M.;
RT "Full haplotype sequences of the killer immunoglobulin-like receptor (kir)
RT region in several diverse diploid individuals using single molecule, real-
RT time sequencing.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [8]
RP GENE FAMILY.
RX PubMed=12185535; DOI=10.1007/s00251-002-0476-2;
RA Gomez-Lozano N., Gardiner C.M., Parham P., Vilches C.;
RT "Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and
RT KIR2DL5B.";
RL Immunogenetics 54:314-319(2002).
CC -!- FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles.
CC Inhibits the activity of NK cells thus preventing cell lysis.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
CC -!- CAUTION: The KIR2DL5B gene is not directly represented on the GRCh38
CC primary reference genome assembly but on alternate loci of that
CC assembly. {ECO:0000305}.
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DR EMBL; EF379093; ABM92652.1; -; Genomic_DNA.
DR EMBL; GU182339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GU182347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GU182351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JX008030; AFV74764.1; -; Genomic_DNA.
DR EMBL; AF272157; AAG44797.1; -; Genomic_DNA.
DR EMBL; AF271608; AAG44778.1; -; mRNA.
DR EMBL; LM656213; CDX48185.1; -; Genomic_DNA.
DR EMBL; KP420440; AJI81002.1; -; Genomic_DNA.
DR RefSeq; XP_016885731.1; XM_017030242.1.
DR RefSeq; XP_016885761.1; XM_017030272.1.
DR AlphaFoldDB; Q8NHK3; -.
DR SMR; Q8NHK3; -.
DR GlyGen; Q8NHK3; 1 site.
DR iPTMnet; Q8NHK3; -.
DR PhosphoSitePlus; Q8NHK3; -.
DR BioMuta; KIR2DL5B; -.
DR DMDM; 74760352; -.
DR MassIVE; Q8NHK3; -.
DR PRIDE; Q8NHK3; -.
DR DNASU; 553128; -.
DR Ensembl; ENST00000615475.1; ENSP00000480935.1; ENSG00000278481.1.
DR Ensembl; ENST00000615969.1; ENSP00000479965.1; ENSG00000275937.1.
DR Ensembl; ENST00000620281.4; ENSP00000478053.1; ENSG00000275436.5.
DR Ensembl; ENST00000638620.1; ENSP00000492850.1; ENSG00000284089.3.
DR Ensembl; ENST00000647415.1; ENSP00000495717.1; ENSG00000284089.3.
DR GeneID; 553128; -.
DR UCSC; uc032lsl.2; human.
DR CTD; 553128; -.
DR GeneCards; KIR2DL5B; -.
DR HGNC; HGNC:16346; KIR2DL5B.
DR MIM; 615727; gene.
DR neXtProt; NX_Q8NHK3; -.
DR PharmGKB; PA142671591; -.
DR InParanoid; Q8NHK3; -.
DR OrthoDB; 1055520at2759; -.
DR BioGRID-ORCS; 553128; 1 hit in 32 CRISPR screens.
DR GenomeRNAi; 553128; -.
DR Pharos; Q8NHK3; Tdark.
DR PRO; PR:Q8NHK3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NHK3; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..375
FT /note="Killer cell immunoglobulin-like receptor 2DL5B"
FT /id="PRO_5000058328"
FT TOPO_DOM 22..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..102
FT /note="Ig-like C2-type 1"
FT DOMAIN 137..200
FT /note="Ig-like C2-type 2"
FT REGION 213..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..95
FT /evidence="ECO:0000250"
FT DISULFID 144..193
FT /evidence="ECO:0000250"
FT VARIANT 6
FT /note="V -> I"
FT /evidence="ECO:0000269|Ref.4"
FT /id="VAR_080174"
FT VARIANT 141
FT /note="T -> A"
FT /evidence="ECO:0000269|Ref.4"
FT /id="VAR_080175"
FT VARIANT 276
FT /note="E -> G"
FT /evidence="ECO:0000269|Ref.4"
FT /id="VAR_080176"
FT CONFLICT 320
FT /note="T -> A (in Ref. 4; AAG44778)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 40695 MW; 190E7A36FD9BD487 CRC64;
MSLMVVSMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL
YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL
FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVDGTFQADF
PLGPATHGGT YTCFSSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH
ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ
LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL
SQNRVASSHV PAAGI
