KI2S2_HUMAN
ID KI2S2_HUMAN Reviewed; 304 AA.
AC P43631; Q14955; Q6H2G9;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Killer cell immunoglobulin-like receptor 2DS2 {ECO:0000305};
DE AltName: Full=CD158 antigen-like family member J;
DE AltName: Full=NK receptor 183 ActI;
DE AltName: Full=Natural killer-associated transcript 5;
DE Short=NKAT-5;
DE AltName: Full=p58 natural killer cell receptor clone CL-49;
DE Short=p58 NK receptor CL-49;
DE AltName: CD_antigen=CD158j;
DE Flags: Precursor;
GN Name=KIR2DS2 {ECO:0000312|HGNC:HGNC:6334}; Synonyms=CD158J, NKAT5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-304.
RC TISSUE=Natural killer cell;
RX PubMed=7749980; DOI=10.1016/1074-7613(95)90025-x;
RA Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M.,
RA Bottino C., Moretta L., Moretta A., Long E.O.;
RT "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related
RT molecules with diversity in both the extra- and intracellular domains.";
RL Immunity 2:439-449(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7716543; DOI=10.1126/science.7716543;
RA Colonna M., Samaridis J.;
RT "Cloning of immunoglobulin-superfamily members associated with HLA-C and
RT HLA-B recognition by human natural killer cells.";
RL Science 268:405-408(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lymphoid tissue;
RX PubMed=8627176; DOI=10.1084/jem.183.2.645;
RA Biassoni R., Cantoni C., Falco M., Verdiani S., Bottino C., Vitale M.,
RA Conte R., Poggi A., Moretta A., Moretta L.;
RT "The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory'
RT natural killer cell receptors display highly homologous extracellular
RT domains but differ in their transmembrane and intracytoplasmic portions.";
RL J. Exp. Med. 183:645-650(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14607943; DOI=10.4049/jimmunol.171.10.5396;
RA Artavanis-Tsakonas K., Eleme K., McQueen K.L., Cheng N.W., Parham P.,
RA Davis D.M., Riley E.M.;
RT "Activation of a subset of human NK cells upon contact with Plasmodium
RT falciparum-infected erythrocytes.";
RL J. Immunol. 171:5396-5405(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 22-221, AND DISULFIDE BONDS.
RX PubMed=12668644; DOI=10.1084/jem.20021624;
RA Saulquin X., Gastinel L.N., Vivier E.;
RT "Crystal structure of the human natural killer cell activating receptor
RT KIR2DS2 (CD158j).";
RL J. Exp. Med. 197:933-938(2003).
CC -!- FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does
CC not inhibit the activity of NK cells.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC50338.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U24079; AAC50338.1; ALT_INIT; mRNA.
DR EMBL; L41347; AAA65225.1; -; mRNA.
DR EMBL; X89893; CAA61983.1; -; mRNA.
DR EMBL; AY366243; AAR16201.1; -; mRNA.
DR EMBL; AL133414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001278624.1; NM_001291695.1.
DR RefSeq; NP_001278625.1; NM_001291696.1.
DR RefSeq; NP_001278629.1; NM_001291700.1.
DR RefSeq; NP_001278630.1; NM_001291701.1.
DR RefSeq; NP_036444.1; NM_012312.4.
DR RefSeq; XP_016885764.1; XM_017030275.1.
DR PDB; 1M4K; X-ray; 2.30 A; A=22-221.
DR PDB; 4N8V; X-ray; 2.50 A; G/I=22-221.
DR PDB; 7DUU; X-ray; 2.51 A; D=22-221.
DR PDBsum; 1M4K; -.
DR PDBsum; 4N8V; -.
DR PDBsum; 7DUU; -.
DR AlphaFoldDB; P43631; -.
DR SMR; P43631; -.
DR BioGRID; 110005; 63.
DR BioGRID; 110008; 41.
DR BioGRID; 125444; 50.
DR IntAct; P43631; 22.
DR GlyGen; P43631; 3 sites.
DR iPTMnet; P43631; -.
DR PhosphoSitePlus; P43631; -.
DR BioMuta; KIR2DS2; -.
DR DMDM; 13124793; -.
DR jPOST; P43631; -.
DR MassIVE; P43631; -.
DR PeptideAtlas; P43631; -.
DR PRIDE; P43631; -.
DR DNASU; 100132285; -.
DR Ensembl; ENST00000610441.1; ENSP00000484281.1; ENSG00000277885.1.
DR Ensembl; ENST00000611495.1; ENSP00000484082.1; ENSG00000276425.1.
DR Ensembl; ENST00000612182.1; ENSP00000478509.1; ENSG00000274438.1.
DR Ensembl; ENST00000613378.1; ENSP00000482725.1; ENSG00000274518.1.
DR Ensembl; ENST00000614231.1; ENSP00000482770.1; ENSG00000275253.1.
DR Ensembl; ENST00000614727.4; ENSP00000483792.1; ENSG00000276139.4.
DR Ensembl; ENST00000616472.1; ENSP00000482637.1; ENSG00000275452.2.
DR Ensembl; ENST00000616541.4; ENSP00000484771.1; ENSG00000278300.4.
DR Ensembl; ENST00000617284.4; ENSP00000478014.1; ENSG00000278300.4.
DR Ensembl; ENST00000617984.1; ENSP00000477892.1; ENSG00000275737.1.
DR Ensembl; ENST00000618364.1; ENSP00000483804.1; ENSG00000275735.1.
DR Ensembl; ENST00000619473.1; ENSP00000484400.1; ENSG00000276258.1.
DR Ensembl; ENST00000622127.1; ENSP00000481307.1; ENSG00000278152.2.
DR GeneID; 100132285; -.
DR KEGG; hsa:100132285; -.
DR UCSC; uc032izx.2; human.
DR CTD; 100132285; -.
DR DisGeNET; 100132285; -.
DR GeneCards; KIR2DS2; -.
DR HGNC; HGNC:6334; KIR2DS2.
DR MIM; 604953; gene.
DR neXtProt; NX_P43631; -.
DR PharmGKB; PA30119; -.
DR InParanoid; P43631; -.
DR OrthoDB; 1055520at2759; -.
DR PathwayCommons; P43631; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-HSA-2172127; DAP12 interactions.
DR SignaLink; P43631; -.
DR BioGRID-ORCS; 100132285; 0 hits in 35 CRISPR screens.
DR EvolutionaryTrace; P43631; -.
DR GenomeRNAi; 100132285; -.
DR Pharos; P43631; Tdark.
DR PRO; PR:P43631; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P43631; protein.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; NAS:UniProtKB.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR GO; GO:0002222; P:stimulatory killer cell immunoglobulin-like receptor signaling pathway; IDA:UniProtKB.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..304
FT /note="Killer cell immunoglobulin-like receptor 2DS2"
FT /id="PRO_0000015083"
FT TOPO_DOM 22..245
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..107
FT /note="Ig-like C2-type 1"
FT DOMAIN 142..205
FT /note="Ig-like C2-type 2"
FT REGION 220..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 211
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..100
FT /evidence="ECO:0000269|PubMed:12668644"
FT DISULFID 149..198
FT /evidence="ECO:0000269|PubMed:12668644"
FT VARIANT 9
FT /note="A -> V (in dbSNP:rs189739973)"
FT /id="VAR_059420"
FT VARIANT 66
FT /note="Y -> F (in dbSNP:rs1049626616)"
FT /id="VAR_059421"
FT VARIANT 237
FT /note="K -> E (in dbSNP:rs2262065)"
FT /id="VAR_020090"
FT VARIANT 254
FT /note="K -> N (in dbSNP:rs1063326)"
FT /id="VAR_059422"
FT CONFLICT 20
FT /note="W -> G (in Ref. 3; CAA61983)"
FT /evidence="ECO:0000305"
FT STRAND 30..35
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 37..40
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 45..53
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 56..62
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 68..73
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 75..79
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 81..87
FT /evidence="ECO:0007829|PDB:1M4K"
FT HELIX 92..94
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 96..103
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 105..108
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 118..123
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 130..135
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 137..139
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 143..162
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 169..172
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 180..189
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 194..201
FT /evidence="ECO:0007829|PDB:1M4K"
FT STRAND 205..209
FT /evidence="ECO:0007829|PDB:4N8V"
FT STRAND 216..220
FT /evidence="ECO:0007829|PDB:1M4K"
SQ SEQUENCE 304 AA; 33502 MW; 186C77DD9E86BA28 CRC64;
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFEHFLL
HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT
FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN
PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE
VSYA
