KI2S3_HUMAN
ID KI2S3_HUMAN Reviewed; 304 AA.
AC Q14952; O00644;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Killer cell immunoglobulin-like receptor 2DS3 {ECO:0000305};
DE AltName: Full=Natural killer-associated transcript 7;
DE Short=NKAT-7;
DE Flags: Precursor;
GN Name=KIR2DS3 {ECO:0000312|HGNC:HGNC:6335}; Synonyms=NKAT7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8662091; DOI=10.1007/bf02602590;
RA Doehring C., Samaridis J., Colonna M.;
RT "Alternatively spliced forms of human killer inhibitory receptors.";
RL Immunogenetics 44:227-230(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lymphoid tissue;
RA Biassoni R.;
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9430221; DOI=10.1016/s1074-7613(00)80394-5;
RA Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K.,
RA Corliss B., Tyan D., Lanier L.L., Parham P.;
RT "Human diversity in killer cell inhibitory receptor genes.";
RL Immunity 7:753-763(1997).
CC -!- FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does
CC not inhibit the activity of NK cells.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR EMBL; L76670; AAB36598.1; -; mRNA.
DR EMBL; X97231; CAA65870.1; -; mRNA.
DR EMBL; AF022047; AAB95320.1; -; mRNA.
DR RefSeq; NP_036445.1; NM_012313.1.
DR AlphaFoldDB; Q14952; -.
DR SMR; Q14952; -.
DR BioGRID; 110009; 32.
DR IntAct; Q14952; 1.
DR GlyGen; Q14952; 3 sites.
DR iPTMnet; Q14952; -.
DR PhosphoSitePlus; Q14952; -.
DR BioMuta; KIR2DS3; -.
DR jPOST; Q14952; -.
DR MassIVE; Q14952; -.
DR PeptideAtlas; Q14952; -.
DR PRIDE; Q14952; -.
DR ProteomicsDB; 60255; -.
DR DNASU; 3808; -.
DR Ensembl; ENST00000611193.1; ENSP00000479108.1; ENSG00000277657.1.
DR Ensembl; ENST00000613265.1; ENSP00000480969.1; ENSG00000278306.1.
DR Ensembl; ENST00000614725.1; ENSP00000483315.1; ENSG00000277163.1.
DR Ensembl; ENST00000638688.2; ENSP00000491727.1; ENSG00000284039.3.
DR Ensembl; ENST00000646148.2; ENSP00000496477.1; ENSG00000284039.3.
DR GeneID; 3808; -.
DR KEGG; hsa:3808; -.
DR UCSC; uc032lso.2; human.
DR CTD; 3808; -.
DR DisGeNET; 3808; -.
DR GeneCards; KIR2DS3; -.
DR HGNC; HGNC:6335; KIR2DS3.
DR MIM; 604954; gene.
DR neXtProt; NX_Q14952; -.
DR PharmGKB; PA30120; -.
DR InParanoid; Q14952; -.
DR OrthoDB; 1055520at2759; -.
DR PhylomeDB; Q14952; -.
DR PathwayCommons; Q14952; -.
DR SignaLink; Q14952; -.
DR BioGRID-ORCS; 3808; 1 hit in 30 CRISPR screens.
DR GenomeRNAi; 3808; -.
DR Pharos; Q14952; Tdark.
DR PRO; PR:Q14952; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q14952; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..304
FT /note="Killer cell immunoglobulin-like receptor 2DS3"
FT /id="PRO_0000015084"
FT TOPO_DOM 22..245
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..107
FT /note="Ig-like C2-type 1"
FT DOMAIN 142..205
FT /note="Ig-like C2-type 2"
FT REGION 220..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..100
FT /evidence="ECO:0000250|UniProtKB:P43626"
FT DISULFID 149..198
FT /evidence="ECO:0000250|UniProtKB:P43626"
SQ SEQUENCE 304 AA; 33717 MW; 80693F79844F9E7E CRC64;
MSLMVISMAC VGFFWLQGAW PHEGFRRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL
HREGTFNDTL RLIGEHIDGV SKANFSIGRM RQDLAGTYRC YGSVPHSPYQ FSAPSDPLDI
VITGLYEKPS LSAQPGPTVL AGESVTLSCS SWSSYDMYHL STEGEAHERR FSAGPKVNGT
FQADFPLGPA TQGGTYRCFG SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN
PRHLHVLIGT SVVKLPFTIL LFFLLHRWCS DKKNASVMDQ GPAGNRTVNR EDSDEQDHQE
VSYA
