ID   KI3L1_MOUSE             Reviewed;         432 AA.
AC   P83555;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Killer cell immunoglobulin-like receptor 3DL1;
DE   AltName: CD_antigen=CD158e;
DE   Flags: Precursor;
GN   Name=Kir3dl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000312|EMBL:AAN05414.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Natural killer cell;
RX   PubMed=12594244; DOI=10.4049/jimmunol.170.5.2259;
RA   Hoelsbrekken S.E., Nylenna O., Saether P.C., Slettedal I.O., Ryan J.C.,
RA   Fossum S., Dissen E.;
RT   "Molecular cloning of a killer cell Ig-like receptor in the mouse and
RT   rat.";
RL   J. Immunol. 170:2259-2263(2003).
CC   -!- FUNCTION: Receptor on natural killer (NK) cells. Inhibits the activity
CC       of NK cells thus preventing cell lysis. {ECO:0000250|UniProtKB:P43629,
CC       ECO:0000269|PubMed:12594244}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR   EMBL; AY130461; AAN05414.1; -; mRNA.
DR   AlphaFoldDB; P83555; -.
DR   SMR; P83555; -.
DR   STRING; 10090.ENSMUSP00000108729; -.
DR   GlyGen; P83555; 3 sites.
DR   PaxDb; P83555; -.
DR   PeptideAtlas; P83555; -.
DR   PRIDE; P83555; -.
DR   MGI; MGI:2652397; Kir3dl1.
DR   eggNOG; ENOG502RU21; Eukaryota.
DR   InParanoid; P83555; -.
DR   PhylomeDB; P83555; -.
DR   Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   PRO; PR:P83555; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P83555; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 2.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..432
FT                   /note="Killer cell immunoglobulin-like receptor 3DL1"
FT                   /id="PRO_0000015088"
FT   TOPO_DOM        22..335
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        357..432
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..100
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          135..202
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          238..301
FT                   /note="Ig-like C2-type 3"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        300
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..95
FT                   /evidence="ECO:0000250"
FT   DISULFID        142..195
FT                   /evidence="ECO:0000250"
FT   DISULFID        245..294
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   432 AA;  48618 MW;  449C2B4EDDF67D95 CRC64;
     MLLWFLSLVC SGFFLVQRMS AHVGSHDKPF LSAWPSYVVP LGQNVTLTCD SHRGSNIFKL
     YKEEGSPNHQ LHETTFQKSQ VFGPVTTEHA GTYRCFHPQY ANVLSAHSEP LKIIISGIYM
     KPFLLILQSP LVDTGGNVTL ECHSENMFDT YILISHRMGI IKNSVQVSAE HHESGSHVTY
     SIGPMTPDLV GTYTCYGANS YYPYEWSDSS DPIDIKITGV YKKPSLSALM GPVLMMSGET
     MALSCISDHQ FDTFHMSREG VPRGQGMPAV QSHSGKFEAK FLLSPMIQKG NYRCYGSFRN
     ASHVWSSPSD PLYLPAKGNC PAYTEADTKT NNYKNLHILT GLLVTMVLVV IIIFYSCYFS
     KQNKSQKQAA ASMEQEYEVK NTINTQNFEG QERQEVTYTE LEQRIFNQNL MPPISRISEF
     SADTIVYMEI MK