KI3L1_RAT
ID KI3L1_RAT Reviewed; 422 AA.
AC P83556;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Killer cell immunoglobulin-like receptor 3DL1;
DE AltName: CD_antigen=CD158e;
DE Flags: Precursor;
GN Name=Kir3dl1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000312|EMBL:AAO47865.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=PVG; TISSUE=Natural killer cell;
RX PubMed=12594244; DOI=10.4049/jimmunol.170.5.2259;
RA Hoelsbrekken S.E., Nylenna O., Saether P.C., Slettedal I.O., Ryan J.C.,
RA Fossum S., Dissen E.;
RT "Molecular cloning of a killer cell Ig-like receptor in the mouse and
RT rat.";
RL J. Immunol. 170:2259-2263(2003).
CC -!- FUNCTION: Receptor on natural killer (NK) cells. Inhibits the activity
CC of NK cells thus preventing cell lysis. {ECO:0000250|UniProtKB:P43629,
CC ECO:0000269|PubMed:12594244}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR EMBL; AF527797; AAO47865.1; -; mRNA.
DR RefSeq; NP_852144.1; NM_181479.2.
DR AlphaFoldDB; P83556; -.
DR SMR; P83556; -.
DR STRING; 10116.ENSRNOP00000031521; -.
DR GlyGen; P83556; 5 sites.
DR PaxDb; P83556; -.
DR Ensembl; ENSRNOT00000039823; ENSRNOP00000031521; ENSRNOG00000027843.
DR GeneID; 353253; -.
DR KEGG; rno:353253; -.
DR UCSC; RGD:727836; rat.
DR CTD; 3811; -.
DR RGD; 727836; Kir3dl1.
DR eggNOG; ENOG502RU21; Eukaryota.
DR GeneTree; ENSGT01000000214458; -.
DR HOGENOM; CLU_021100_2_1_1; -.
DR InParanoid; P83556; -.
DR OMA; MACVETH; -.
DR OrthoDB; 1055520at2759; -.
DR PhylomeDB; P83556; -.
DR TreeFam; TF352669; -.
DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR PRO; PR:P83556; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000027843; Expressed in jejunum.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..422
FT /note="Killer cell immunoglobulin-like receptor 3DL1"
FT /id="PRO_0000015089"
FT TOPO_DOM 22..329
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..422
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..100
FT /note="Ig-like C2-type 1"
FT DOMAIN 135..202
FT /note="Ig-like C2-type 2"
FT DOMAIN 237..300
FT /note="Ig-like C2-type 3"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 239
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 142..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 244..293
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 422 AA; 48074 MW; 91E5CE3EFA2DDE70 CRC64;
MMFEFLSLLC SGFFLVQRMS AHMGSYDKPF LCASPSYIVP QGQNVTLICD SHSKPNIFKV
YKEDGFPILQ LHEKTFTKSL DIGPVTPEYA GTYRCFHHQY PNEISAHSEP LKIIISGIYM
KPFLIAPQTP LANSGENVTL ECHSEIMFDT YILTSHRMEI LKETLQHFQE SHFSGSYASF
TIGPMTPDHS GTYTCYGAYN HSLYEWSDSS DPVDIKITGE YKKPSLSSVM SPVLVSEQNM
TLSCISNHQF EMFHLSREGV PQGKGIPAMQ SHSGKFEAKF LLSPVIQKGN YRCYGSFKNS
SHVWSSPSDP LYLPAKDNLK NLHIQIGLLV TMVLVIVVII IIIIIIIIII YYYYFSKKSS
ILEQESEVKA TINRQDPERQ EEHKVTYIEF EQRIFNKNLM PPISQSPKEF SIDTVVYTEV
MI