ID   KI3L1_RAT               Reviewed;         422 AA.
AC   P83556;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Killer cell immunoglobulin-like receptor 3DL1;
DE   AltName: CD_antigen=CD158e;
DE   Flags: Precursor;
GN   Name=Kir3dl1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000312|EMBL:AAO47865.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=PVG; TISSUE=Natural killer cell;
RX   PubMed=12594244; DOI=10.4049/jimmunol.170.5.2259;
RA   Hoelsbrekken S.E., Nylenna O., Saether P.C., Slettedal I.O., Ryan J.C.,
RA   Fossum S., Dissen E.;
RT   "Molecular cloning of a killer cell Ig-like receptor in the mouse and
RT   rat.";
RL   J. Immunol. 170:2259-2263(2003).
CC   -!- FUNCTION: Receptor on natural killer (NK) cells. Inhibits the activity
CC       of NK cells thus preventing cell lysis. {ECO:0000250|UniProtKB:P43629,
CC       ECO:0000269|PubMed:12594244}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR   EMBL; AF527797; AAO47865.1; -; mRNA.
DR   RefSeq; NP_852144.1; NM_181479.2.
DR   AlphaFoldDB; P83556; -.
DR   SMR; P83556; -.
DR   STRING; 10116.ENSRNOP00000031521; -.
DR   GlyGen; P83556; 5 sites.
DR   PaxDb; P83556; -.
DR   Ensembl; ENSRNOT00000039823; ENSRNOP00000031521; ENSRNOG00000027843.
DR   GeneID; 353253; -.
DR   KEGG; rno:353253; -.
DR   UCSC; RGD:727836; rat.
DR   CTD; 3811; -.
DR   RGD; 727836; Kir3dl1.
DR   eggNOG; ENOG502RU21; Eukaryota.
DR   GeneTree; ENSGT01000000214458; -.
DR   HOGENOM; CLU_021100_2_1_1; -.
DR   InParanoid; P83556; -.
DR   OMA; MACVETH; -.
DR   OrthoDB; 1055520at2759; -.
DR   PhylomeDB; P83556; -.
DR   TreeFam; TF352669; -.
DR   Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   PRO; PR:P83556; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000027843; Expressed in jejunum.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042267; P:natural killer cell mediated cytotoxicity; ISO:RGD.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..422
FT                   /note="Killer cell immunoglobulin-like receptor 3DL1"
FT                   /id="PRO_0000015089"
FT   TOPO_DOM        22..329
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        351..422
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..100
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          135..202
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          237..300
FT                   /note="Ig-like C2-type 3"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        200
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        239
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        299
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..95
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        142..195
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        244..293
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   422 AA;  48074 MW;  91E5CE3EFA2DDE70 CRC64;
     MMFEFLSLLC SGFFLVQRMS AHMGSYDKPF LCASPSYIVP QGQNVTLICD SHSKPNIFKV
     YKEDGFPILQ LHEKTFTKSL DIGPVTPEYA GTYRCFHHQY PNEISAHSEP LKIIISGIYM
     KPFLIAPQTP LANSGENVTL ECHSEIMFDT YILTSHRMEI LKETLQHFQE SHFSGSYASF
     TIGPMTPDHS GTYTCYGAYN HSLYEWSDSS DPVDIKITGE YKKPSLSSVM SPVLVSEQNM
     TLSCISNHQF EMFHLSREGV PQGKGIPAMQ SHSGKFEAKF LLSPVIQKGN YRCYGSFKNS
     SHVWSSPSDP LYLPAKDNLK NLHIQIGLLV TMVLVIVVII IIIIIIIIII YYYYFSKKSS
     ILEQESEVKA TINRQDPERQ EEHKVTYIEF EQRIFNKNLM PPISQSPKEF SIDTVVYTEV
     MI