KI3L3_HUMAN
ID KI3L3_HUMAN Reviewed; 410 AA.
AC Q8N743; A0A0B4J1R5; A9PL62; A9PL64; A9PL65; A9PL66; A9PL67; A9PL68; A9PZV4;
AC A9PZV7; A9PZV8; A9Q066; A9Q0R5; A9Q242; A9Q250; A9Q251; O95056; Q1X775;
AC Q1X777; Q1X778; Q1X779; Q1X780; Q1X781; Q1X782; Q1X783; Q7Z7N4; Q8NHI2;
AC Q8NHI3; Q9UEI4;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Killer cell immunoglobulin-like receptor 3DL3;
DE AltName: Full=CD158 antigen-like family member Z;
DE AltName: Full=Killer cell inhibitory receptor 1;
DE AltName: CD_antigen=CD158z;
DE Flags: Precursor;
GN Name=KIR3DL3; Synonyms=CD158Z, KIR3DL7, KIRC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000312|EMBL:CAC40702.1};
RN [1] {ECO:0000312|EMBL:AAC99763.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE KIR3DL3*00101), VARIANTS ILE-168
RP AND ASN-321, AND POLYMORPHISM.
RX PubMed=9862332;
RX DOI=10.1002/(sici)1521-4141(199812)28:12<3959::aid-immu3959>3.0.co;2-2;
RA Torkar M., Norgate Z., Colonna M., Trowsdale J., Wilson M.J.;
RT "Isotypic variation of novel immunoglobulin-like transcript/killer cell
RT inhibitory receptor loci in the leukocyte receptor complex.";
RL Eur. J. Immunol. 28:3959-3967(1998).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE KIR3DL3*00401), VARIANTS HIS-52 AND
RP TYR-321, POLYMORPHISM, AND REVIEW.
RC TISSUE=Peripheral blood {ECO:0000312|EMBL:AAK30258.1};
RX PubMed=11513144; DOI=10.1034/j.1600-065x.2001.1810119.x;
RA Long E.O., Barber D.F., Burshtyn D.N., Faure M., Peterson M.,
RA Rajagopalan S., Renard V., Sandusky M., Stebbins C.C., Wagtmann N.,
RA Watzl C.;
RT "Inhibition of natural killer cell activation signals by killer cell
RT immunoglobulin-like receptors (CD158).";
RL Immunol. Rev. 181:223-233(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TYR-321.
RA Roe D., Vierra-Green C., Pyo C.-W., Eng K., Hall R., Spellman S.,
RA Ranade S., Geraghty D.E., Maiers M.;
RT "Full haplotype sequences of the killer immunoglobulin-like receptor (kir)
RT region in several diverse diploid individuals using single molecule, real-
RT time sequencing.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-410 (ALLELES KIR3DL3*00101;
RP KIR3DL3*00202; KIR3DL3*0030101; KIR3DL3*00402; KIR3DL3*005; KIR3DL3*00601;
RP KIR3DL3*007; KIR3DL3*00801 AND KIR3DL3*00802), AND POLYMORPHISM.
RX PubMed=16634863; DOI=10.1111/j.1399-0039.2006.00567.x;
RA Steiner N.K., Hurley C.K.;
RT "KIR3DL3 allelic diversity: six new alleles exhibit both conservative and
RT non-conservative substitutions.";
RL Tissue Antigens 67:277-283(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-410 (ALLELES KIR3DL3*00101;
RP KIR3DL3*00102; KIR3DL3*00103; KIR3DL3*00206; KIR3DL3*00207;
RP KIR3DL3*0030101; KIR3DL3*00402; KIR3DL3*005; KIR3DL3*00602; KIR3DL3*007;
RP KIR3DL3*00901; KIR3DL3*00902; KIR3DL3*010; KIR3DL3*01101; KIR3DL3*01102;
RP KIR3DL3*01302; KIR3DL3*01305; KIR3DL3*01306; KIR3DL3*01307; KIR3DL3*01404;
RP KIR3DL3*01405; KIR3DL3*01501; KIR3DL3*01601; KIR3DL3*017; KIR3DL3*026;
RP KIR3DL3*027; KIR3DL3*028; KIR3DL3*029; KIR3DL3*030 AND KIR3DL3*031), AND
RP POLYMORPHISM.
RX PubMed=17900289; DOI=10.1111/j.1399-0039.2007.00930.x;
RA Hou L., Chen M., Steiner N.K., Belle I., Turino C., Ng J., Hurley C.K.;
RT "Seventeen novel alleles add to the already extensive KIR3DL3 diversity.";
RL Tissue Antigens 70:449-454(2007).
RN [7] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-316, AND VARIANT THR-290.
RX PubMed=11960306; DOI=10.1038/sj.gene.6363836;
RA Norman P.J., Carrington C.V.F., Byng M., Maxwell L.D., Curran M.D.,
RA Stephens H.A.F., Chandanayingyong D., Verity D.H., Hameed K., Ramdath D.D.,
RA Vaughan R.W.;
RT "Natural killer immunoglobulin-like receptor (KIR) locus profiles in
RT African and South Asian populations.";
RL Genes Immun. 3:86-95(2002).
CC -!- FUNCTION: Receptor on natural killer cells. May inhibit the activity of
CC NK cells thus preventing cell lysis. {ECO:0000303|PubMed:11513144}.
CC -!- INTERACTION:
CC Q8N743; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-17272405, EBI-10225815;
CC Q8N743; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-17272405, EBI-11522760;
CC Q8N743; P78348: ASIC1; NbExp=3; IntAct=EBI-17272405, EBI-79189;
CC Q8N743; P01031: C5; NbExp=3; IntAct=EBI-17272405, EBI-8558308;
CC Q8N743; P19397: CD53; NbExp=3; IntAct=EBI-17272405, EBI-6657396;
CC Q8N743; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-17272405, EBI-11522780;
CC Q8N743; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-17272405, EBI-12019274;
CC Q8N743; P56851: EDDM3B; NbExp=3; IntAct=EBI-17272405, EBI-10215665;
CC Q8N743; P54852: EMP3; NbExp=3; IntAct=EBI-17272405, EBI-3907816;
CC Q8N743; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-17272405, EBI-6166686;
CC Q8N743; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-17272405, EBI-10266796;
CC Q8N743; Q13571: LAPTM5; NbExp=3; IntAct=EBI-17272405, EBI-2865663;
CC Q8N743; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-17272405, EBI-10317425;
CC Q8N743; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-17272405, EBI-2804156;
CC Q8N743; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-17272405, EBI-10329948;
CC Q8N743; P78382: SLC35A1; NbExp=3; IntAct=EBI-17272405, EBI-12870360;
CC Q8N743; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-17272405, EBI-10290130;
CC Q8N743; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-17272405, EBI-741850;
CC Q8N743; Q8N2H4: SYS1; NbExp=3; IntAct=EBI-17272405, EBI-13075176;
CC Q8N743; Q9H2S6-2: TNMD; NbExp=3; IntAct=EBI-17272405, EBI-12003398;
CC Q8N743; O00526: UPK2; NbExp=3; IntAct=EBI-17272405, EBI-10179682;
CC Q8N743; O95183: VAMP5; NbExp=3; IntAct=EBI-17272405, EBI-10191195;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- POLYMORPHISM: Various different KIR3DL3 alleles are known:
CC KIR3DL3*00101, KIR3DL3*00102, KIR3DL3*00103, KIR3DL3*00201,
CC KIR3DL3*00202, KIR3DL3*00203, KIR3DL3*00204, KIR3DL3*00205,
CC KIR3DL3*00206, KIR3DL3*00207, KIR3DL3*0030101 KIR3DL3*0030102,
CC KIR3DL3*00401, KIR3DL3*00402, KIR3DL3*005, KIR3DL3*00601,
CC KIR3DL3*00602, KIR3DL3*007, KIR3DL3*00801, KIR3DL3*00802,
CC KIR3DL3*00901, KIR3DL3*00902, KIR3DL3*010, KIR3DL3*01101,
CC KIR3DL3*01102, KIR3DL3*012, KIR3DL3*01301, KIR3DL3*01302,
CC KIR3DL3*01303, KIR3DL3*01304, KIR3DL3*01305, KIR3DL3*01306,
CC KIR3DL3*01307, KIR3DL3*01401, KIR3DL3*01402, KIR3DL3*01403,
CC KIR3DL3*01404, KIR3DL3*01405, KIR3DL3*015 KIR3DL3*016, KIR3DL3*017,
CC KIR3DL3*018, KIR3DL3*019, KIR3DL3*020, KIR3DL3*021, KIR3DL3*022,
CC KIR3DL3*023, KIR3DL3*024, KIR3DL3*025, KIR3DL3*026, KIR3DL3*027,
CC KIR3DL3*028, KIR3DL3*029, KIR3DL3*030 and KIR3DL3*031. The sequence
CC shown corresponds to the alleles KIR3DL3*002.
CC {ECO:0000269|PubMed:11513144, ECO:0000269|PubMed:16634863,
CC ECO:0000269|PubMed:17900289, ECO:0000269|PubMed:9862332}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=IPD-KIR Database; Note=KIR Allele Nomenclature;
CC URL="https://www.ebi.ac.uk/cgi-bin/ipd/kir/view_nomenclature.cgi?kir.3dl3";
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DR EMBL; AF072410; AAC99763.1; -; Genomic_DNA.
DR EMBL; AF072407; AAC99763.1; JOINED; Genomic_DNA.
DR EMBL; AF072408; AAC99763.1; JOINED; Genomic_DNA.
DR EMBL; AF072409; AAC99763.1; JOINED; Genomic_DNA.
DR EMBL; AF352324; AAK30258.1; -; mRNA.
DR EMBL; KU842452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC245128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006293; AAD03159.1; -; Genomic_DNA.
DR EMBL; AL133414; CAC40702.1; -; Genomic_DNA.
DR EMBL; AY987937; ABC03227.1; -; Genomic_DNA.
DR EMBL; AY987938; ABC03228.1; -; Genomic_DNA.
DR EMBL; AY987939; ABC03229.1; -; Genomic_DNA.
DR EMBL; AY987940; ABC03230.1; -; Genomic_DNA.
DR EMBL; AY987941; ABC03231.1; -; Genomic_DNA.
DR EMBL; AY987942; ABC03232.1; -; Genomic_DNA.
DR EMBL; AY987943; ABC03233.1; -; Genomic_DNA.
DR EMBL; AH015397; ABC03234.1; -; Genomic_DNA.
DR EMBL; AH015396; ABC03226.1; -; Genomic_DNA.
DR EMBL; EF153459; ABM98078.1; -; Genomic_DNA.
DR EMBL; EF153460; ABM98079.1; -; Genomic_DNA.
DR EMBL; EF153461; ABM98080.1; -; Genomic_DNA.
DR EMBL; EF153462; ABM98081.1; -; Genomic_DNA.
DR EMBL; EF153463; ABM98082.1; -; Genomic_DNA.
DR EMBL; EF153464; ABM98083.1; -; Genomic_DNA.
DR EMBL; EF153465; ABM98084.1; -; Genomic_DNA.
DR EMBL; EF153466; ABM98085.1; -; Genomic_DNA.
DR EMBL; EF153467; ABM98086.1; -; Genomic_DNA.
DR EMBL; EF165005; ABM98087.1; -; Genomic_DNA.
DR EMBL; EF165006; ABM98088.1; -; Genomic_DNA.
DR EMBL; EF165007; ABM98089.1; -; Genomic_DNA.
DR EMBL; EF165008; ABM98090.1; -; Genomic_DNA.
DR EMBL; EF165009; ABM98091.1; -; Genomic_DNA.
DR EMBL; EF175456; ABM98092.1; -; Genomic_DNA.
DR EMBL; EF175457; ABM98093.1; -; Genomic_DNA.
DR EMBL; EF175458; ABM98094.1; -; Genomic_DNA.
DR EMBL; EF175459; ABM98095.1; -; Genomic_DNA.
DR EMBL; EF175460; ABM98096.1; -; Genomic_DNA.
DR EMBL; EF379094; ABM92653.1; -; Genomic_DNA.
DR EMBL; EF379095; ABM92654.1; -; Genomic_DNA.
DR EMBL; EF492034; ABS30929.1; -; Genomic_DNA.
DR EMBL; EF492035; ABS30930.1; -; Genomic_DNA.
DR EMBL; EF492036; ABS30931.1; -; Genomic_DNA.
DR EMBL; EF492037; ABS30932.1; -; Genomic_DNA.
DR EMBL; EF492038; ABS30933.1; -; Genomic_DNA.
DR EMBL; EF492039; ABS30934.1; -; Genomic_DNA.
DR EMBL; EF492040; ABS30935.1; -; Genomic_DNA.
DR EMBL; EF492041; ABS30936.1; -; Genomic_DNA.
DR EMBL; EF492042; ABS30937.1; -; Genomic_DNA.
DR EMBL; EF492043; ABS30938.1; -; Genomic_DNA.
DR EMBL; EF492044; ABS30939.1; -; Genomic_DNA.
DR EMBL; AH011562; AAM00023.1; -; Genomic_DNA.
DR EMBL; AY083462; AAM00024.1; -; Genomic_DNA.
DR CCDS; CCDS12903.1; -.
DR RefSeq; NP_703144.3; NM_153443.4.
DR AlphaFoldDB; Q8N743; -.
DR SMR; Q8N743; -.
DR BioGRID; 125444; 50.
DR IntAct; Q8N743; 22.
DR STRING; 9606.ENSP00000291860; -.
DR GlyGen; Q8N743; 3 sites.
DR PhosphoSitePlus; Q8N743; -.
DR BioMuta; KIR3DL3; -.
DR DMDM; 269849611; -.
DR jPOST; Q8N743; -.
DR MassIVE; Q8N743; -.
DR PaxDb; Q8N743; -.
DR PeptideAtlas; Q8N743; -.
DR PRIDE; Q8N743; -.
DR Antibodypedia; 52727; 121 antibodies from 16 providers.
DR DNASU; 115653; -.
DR Ensembl; ENST00000613010.1; ENSP00000482580.1; ENSG00000274639.1.
DR Ensembl; ENST00000614568.1; ENSP00000478200.1; ENSG00000276196.1.
DR GeneID; 115653; -.
DR KEGG; hsa:115653; -.
DR UCSC; uc032msg.2; human.
DR CTD; 115653; -.
DR GeneCards; KIR3DL3; -.
DR HGNC; HGNC:16312; KIR3DL3.
DR MIM; 610095; gene.
DR neXtProt; NX_Q8N743; -.
DR PharmGKB; PA134887375; -.
DR VEuPathDB; HostDB:ENSG00000242019; -.
DR eggNOG; ENOG502RU21; Eukaryota.
DR HOGENOM; CLU_021100_2_1_1; -.
DR InParanoid; Q8N743; -.
DR OMA; GTCKADF; -.
DR OrthoDB; 1055520at2759; -.
DR PhylomeDB; Q8N743; -.
DR TreeFam; TF352669; -.
DR PathwayCommons; Q8N743; -.
DR SignaLink; Q8N743; -.
DR BioGRID-ORCS; 115653; 9 hits in 1056 CRISPR screens.
DR GeneWiki; KIR3DL3; -.
DR GenomeRNAi; 115653; -.
DR Pharos; Q8N743; Tbio.
DR PRO; PR:Q8N743; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N743; protein.
DR Bgee; ENSG00000242019; Expressed in hindlimb stylopod muscle and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; SSF48726; 3.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..410
FT /note="Killer cell immunoglobulin-like receptor 3DL3"
FT /evidence="ECO:0000255"
FT /id="PRO_0000015091"
FT TOPO_DOM 26..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..410
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..97
FT /note="Ig-like C2-type 1"
FT /evidence="ECO:0000305"
FT DOMAIN 137..197
FT /note="Ig-like C2-type 2"
FT /evidence="ECO:0000305"
FT DOMAIN 237..295
FT /note="Ig-like C2-type 3"
FT /evidence="ECO:0000305"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT CARBOHYD 239
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT CARBOHYD 273
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 49..95
FT /evidence="ECO:0000305"
FT DISULFID 144..195
FT /evidence="ECO:0000250|UniProtKB:Q8NHL6"
FT DISULFID 244..293
FT /evidence="ECO:0000250|UniProtKB:Q8NHL6"
FT VARIANT 52
FT /note="R -> H (in allele KIR3DL3*00401, allele
FT KIR3DL3*00402, allele KIR3DL3*00801, allele KIR3DL3*00802
FT and allele KIR3DL3*026; dbSNP:rs113988102)"
FT /evidence="ECO:0000269|PubMed:11513144"
FT /id="VAR_060610"
FT VARIANT 56
FT /note="N -> K (in allele KIR3DL3*00601, allele
FT KIR3DL3*00602, allele KIR3DL3*01501 and allele
FT KIR3DL3*01601; dbSNP:rs2075731)"
FT /id="VAR_060611"
FT VARIANT 77
FT /note="R -> W (in allele KIR3DL3*010 and allele
FT KIR3DL3*028; dbSNP:rs202170060)"
FT /id="VAR_060612"
FT VARIANT 149
FT /note="R -> S (in allele KIR3DL3*00601, allele
FT KIR3DL3*00602, allele KIR3DL3*01501 and allele
FT KIR3DL3*01601; dbSNP:rs62132665)"
FT /id="VAR_060613"
FT VARIANT 152
FT /note="R -> H (in allele KIR3DL3*007, allele KIR3DL3*030
FT and allele KIR3DL3*031; dbSNP:rs199609975)"
FT /id="VAR_060614"
FT VARIANT 168
FT /note="V -> I (in allele KIR3DL3*00101, allele
FT KIR3DL3*00102, allele KIR3DL3*00103, allele
FT KIR3DL3*0030101, allele KIR3DL3*00901, allele
FT KIR3DL3*00902, allele KIR3DL3*010 and allele KIR3DL3*028;
FT dbSNP:rs270790)"
FT /evidence="ECO:0000269|PubMed:9862332"
FT /id="VAR_019426"
FT VARIANT 231
FT /note="G -> D (in allele KIR3DL3*005; dbSNP:rs112412050)"
FT /id="VAR_060615"
FT VARIANT 290
FT /note="N -> T (in allele KIR3DL3*00601, allele
FT KIR3DL3*00602, allele KIR3DL3*01101, allele KIR3DL3*01102,
FT allele KIR3DL3*01501, allele KIR3DL3*01601 and allele
FT KIR3DL3*017; dbSNP:rs2302422)"
FT /evidence="ECO:0000269|PubMed:11960306"
FT /id="VAR_060616"
FT VARIANT 321
FT /note="H -> N (in allele KIR3DL3*00101, allele
FT KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*00601,
FT allele KIR3DL3*00602, allele KIR3DL3*01302, allele
FT KIR3DL3*01305, allele KIR3DL3*01306, allele KIR3DL3*01307,
FT allele KIR3DL3*017 and allele KIR3DL3*026; dbSNP:rs602444)"
FT /evidence="ECO:0000269|PubMed:9862332, ECO:0000269|Ref.3"
FT /id="VAR_060617"
FT VARIANT 321
FT /note="H -> Y (in allele KIR3DL3*00101, allele
FT KIR3DL3*0030101, allele KIR3DL3*00401, allele
FT KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404,
FT allele KIR3DL3*01405, allele KIR3DL3*01601 and allele
FT KIR3DL3*028; dbSNP:rs602444)"
FT /evidence="ECO:0000269|PubMed:11513144"
FT /id="VAR_060618"
FT VARIANT 324
FT /note="V -> A (in allele KIR3DL3*0030101, allele
FT KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007,
FT allele KIR3DL3*01404, allele KIR3DL3*01405, allele
FT KIR3DL3*01601 and allele KIR3DL3*028; dbSNP:rs662386)"
FT /id="VAR_060366"
FT VARIANT 324
FT /note="V -> D (in allele KIR3DL3*029; dbSNP:rs662386)"
FT /id="VAR_060619"
FT VARIANT 348
FT /note="A -> P (in allele KIR3DL3*027, allele KIR3DL3*029
FT and allele KIR3DL3*031; dbSNP:rs16985907)"
FT /id="VAR_056092"
FT VARIANT 373
FT /note="E -> D (in allele KIR3DL3*027, allele KIR3DL3*029
FT and allele KIR3DL3*031; dbSNP:rs28504993)"
FT /id="VAR_060620"
SQ SEQUENCE 410 AA; 44928 MW; D1C4D06DE8FEF35E CRC64;
MSLMVVSMAC VGFFLLEGPW PHVGGQDKPF LSAWPGTVVS EGQHVTLQCR SRLGFNEFSL
SKEDGMPVPE LYNRIFRNSF LMGPVTPAHA GTYRCCSSHP HSPTGWSAPS NPVVIMVTGV
HRKPSLLAHP GPLVKSGETV ILQCWSDVRF ERFLLHREGI TEDPLRLVGQ LHDAGSQVNY
SMGPMTPALA GTYRCFGSVT HLPYELSAPS DPLDIVVVGL YGKPSLSAQP GPTVQAGENV
TLSCSSRSLF DIYHLSREAE AGELRLTAVL RVNGTFQANF PLGPVTHGGN YRCFGSFRAL
PHAWSDPSDP LPVSVTGNSR HLHVLIGTSV VIIPFAILLF FLLHRWCANK KNAVVMDQEP
AGNRTVNRED SDEQDPQEVT YAQLNHCVFT QRKITRPSQR PKTPPTDTSV
