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KI3X1_HUMAN
ID   KI3X1_HUMAN             Reviewed;         352 AA.
AC   Q9H7L2; B7WNL0; Q8N0S4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Putative killer cell immunoglobulin-like receptor-like protein KIR3DX1;
DE   AltName: Full=Leukocyte receptor cluster member 12;
DE   Flags: Precursor;
GN   Name=KIR3DX1; Synonyms=KIR3DL0, LENG12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 117-333.
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=16911775; DOI=10.1186/1471-2164-7-209;
RA   Sambrook J.G., Bashirova A., Andersen H., Piatak M., Vernikos G.S.,
RA   Coggill P., Lifson J.D., Carrington M., Beck S.;
RT   "Identification of the ancestral killer immunoglobulin-like receptor gene
RT   in primates.";
RL   BMC Genomics 7:209-209(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in NK-cells.
CC       {ECO:0000269|PubMed:16911775}.
CC   -!- CAUTION: Could be the product of a pseudogene. According to
CC       PubMed:16911775, it could constitute the ancestral killer
CC       immunoglobulin-like receptor gene in primates. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB15757.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites and probable target of nonsense-mediated mRNA decay.; Evidence={ECO:0000305};
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DR   EMBL; AC009892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK024467; BAB15757.1; ALT_SEQ; mRNA.
DR   EMBL; CH471135; EAW72255.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9H7L2; -.
DR   SMR; Q9H7L2; -.
DR   IntAct; Q9H7L2; 1.
DR   GlyGen; Q9H7L2; 2 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9H7L2; -.
DR   PhosphoSitePlus; Q9H7L2; -.
DR   BioMuta; KIR3DX1; -.
DR   MassIVE; Q9H7L2; -.
DR   PaxDb; Q9H7L2; -.
DR   PeptideAtlas; Q9H7L2; -.
DR   PRIDE; Q9H7L2; -.
DR   Ensembl; ENST00000614511.4; ENSP00000479122.1; ENSG00000276848.4.
DR   Ensembl; ENST00000614591.1; ENSP00000484242.1; ENSG00000275918.4.
DR   Ensembl; ENST00000621920.4; ENSP00000481872.1; ENSG00000276033.4.
DR   UCSC; uc061crn.1; human.
DR   GeneCards; KIR3DX1; -.
DR   HGNC; HGNC:25043; KIR3DX1.
DR   neXtProt; NX_Q9H7L2; -.
DR   HOGENOM; CLU_021100_2_1_1; -.
DR   InParanoid; Q9H7L2; -.
DR   PhylomeDB; Q9H7L2; -.
DR   TreeFam; TF352669; -.
DR   PathwayCommons; Q9H7L2; -.
DR   SignaLink; Q9H7L2; -.
DR   Pharos; Q9H7L2; Tdark.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q9H7L2; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00409; IG; 3.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   5: Uncertain;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..352
FT                   /note="Putative killer cell immunoglobulin-like receptor-
FT                   like protein KIR3DX1"
FT                   /id="PRO_0000349175"
FT   DOMAIN          17..112
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          224..311
FT                   /note="Ig-like C2-type 2"
FT   CARBOHYD        78
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..94
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        244..295
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   352 AA;  38777 MW;  B7EBD744D0061035 CRC64;
     MAPKLITVLC LGFCLNQKIC PHAGAQDKFS LSAWPSPVVP LGGRVTLSCH SHLRFVIWTI
     FQTTGTRSHE LHTGLSNNIT ISPVTPEHAG TYRCVGIYKH ASKWSAESNS LKIIVTGLFT
     KPSISAHPSS LVHAGARVSL RCHSELAFDE FILYKEGHIQ HSQQLDQGME AGIHYVEAVF
     SMGPVTPAHA GAYRCCGCFS HSRYEWSAPS DPLDIVITGK YKKPSLSTQV DPMMRLGEKL
     TLFCSSEISF DQYHLFRHGV AHGQWLSGGQ RHREAFQANF SVGRATPVPG GTYRCYGSFN
     DSPYKPPVTR CNFTPQETLR VLLCHSQNPP LNLTHLALKD SPATCICSLD SQ
 
 
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