KIAS1_HUMAN
ID KIAS1_HUMAN Reviewed; 181 AA.
AC Q9Y6Z4; Q2M1U8; Q5SZV0; Q5SZV1; Q9Y6Z3;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Putative uncharacterized protein KIF25-AS1;
DE AltName: Full=KIF25 antisense RNA 1;
DE AltName: Full=KIF25 antisense gene protein 1;
DE AltName: Full=Protein HGC6.1;
GN Name=KIF25-AS1; Synonyms=C6orf54, NCRNA00300;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT ARG-24.
RC TISSUE=Skeletal muscle;
RX PubMed=10382971; DOI=10.1093/dnares/6.2.131;
RA Minaguchi T., Matsushima M., Saito S., Kanamori Y., Shirahama S.,
RA Okamoto S., Minami M., Taketani Y., Nakamura Y.;
RT "Complete DNA sequence and characterization of a 330-kb VNTR-rich region on
RT chromosome 6q27 that is commonly deleted in ovarian cancer.";
RL DNA Res. 6:131-136(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-24.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9Y6Z4; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-10329963, EBI-751260;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=HGC6.1.1;
CC IsoId=Q9Y6Z4-1; Sequence=Displayed;
CC Name=2; Synonyms=HGC6.1.2;
CC IsoId=Q9Y6Z4-2; Sequence=VSP_007375;
CC -!- CAUTION: Product of a dubious CDS prediction. Probable non-coding RNA.
CC {ECO:0000305}.
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DR EMBL; AB016899; BAA78634.1; -; mRNA.
DR EMBL; AB016900; BAA78635.1; -; mRNA.
DR EMBL; AL589733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112215; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q9Y6Z4; -.
DR IntAct; Q9Y6Z4; 1.
DR BioMuta; HGNC:20953; -.
DR PRIDE; Q9Y6Z4; -.
DR GeneCards; KIF25-AS1; -.
DR HGNC; HGNC:20953; KIF25-AS1.
DR neXtProt; NX_Q9Y6Z4; -.
DR InParanoid; Q9Y6Z4; -.
DR PathwayCommons; Q9Y6Z4; -.
DR ChiTaRS; KIF25-AS1; human.
DR Pharos; Q9Y6Z4; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9Y6Z4; protein.
PE 5: Uncertain;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..181
FT /note="Putative uncharacterized protein KIF25-AS1"
FT /id="PRO_0000089508"
FT REGION 162..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..85
FT /note="MGDIFKNNGVLQGRLRAVACAPHCFGPRLRCLHHDQGLTELAWGTWPHSHPV
FT RHQPQMPSARECCSIVCMAAKEVSAPKAPGSPW -> MESSRAGCVLWPVLLTALDPGC
FT AVSTTTKDSQSSPGGPGPTVTPSVISLKCHQPVNAAPSSAWQPRR (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:10382971"
FT /id="VSP_007375"
FT VARIANT 23
FT /note="H -> D (in dbSNP:rs9355149)"
FT /id="VAR_033051"
FT VARIANT 24
FT /note="C -> R (in dbSNP:rs2516801)"
FT /evidence="ECO:0000269|PubMed:10382971,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_033052"
FT VARIANT 57
FT /note="Q -> E (in dbSNP:rs9364382)"
FT /id="VAR_033053"
FT CONFLICT 133
FT /note="L -> F (in Ref. 1; BAA78635)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="R -> T (in Ref. 1; BAA78635)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 181 AA; 19411 MW; 7795C816E3BEA5DA CRC64;
MGDIFKNNGV LQGRLRAVAC APHCFGPRLR CLHHDQGLTE LAWGTWPHSH PVRHQPQMPS
ARECCSIVCM AAKEVSAPKA PGSPWMVPGD VAMSGHRVGA LDERGHPNPQ TGHCRGGSVS
VTWSSVSCCR GRLAAVRVMI ARDPSTCHLA KGCSPAWGFL PQARGPAGTR TPQRRCSSHE
A
