KIB3_ARATH
ID KIB3_ARATH Reviewed; 450 AA.
AC Q9ZW91;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=F-box protein KIB3 {ECO:0000303|PubMed:28575660};
DE AltName: Full=Protein KINK SUPPRESSED IN BZR1-1D 3 {ECO:0000303|PubMed:28575660};
GN Name=KIB3 {ECO:0000303|PubMed:28575660};
GN OrderedLocusNames=At1g67160 {ECO:0000312|Araport:AT1G67160};
GN ORFNames=F5A8.7 {ECO:0000312|EMBL:AAD10661.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia, and cv. Wassilewskija;
RX PubMed=28575660; DOI=10.1016/j.molcel.2017.05.012;
RA Zhu J.-Y., Li Y., Cao D.-M., Yang H., Oh E., Bi Y., Zhu S., Wang Z.-Y.;
RT "The F-box protein KIB1 mediates brassinosteroid-induced inactivation and
RT degradation of GSK3-like kinases in Arabidopsis.";
RL Mol. Cell 66:648-657(2017).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. Required for
CC brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21
CC inactivation both by competing with substrate binding (e.g. BZR1) and
CC by promoting its ubiquitination and subsequent proteasomal degradation.
CC {ECO:0000269|PubMed:28575660}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9SU05}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9SU05}.
CC -!- DISRUPTION PHENOTYPE: Abolished brassinosteroid (BR)-induced
CC ASK7/BIN2/SK21 degradation, and BR-insensitivity. Suppression of the
CC constitutive BR-response phenotype in the dominant mutant bzr1-1D, and
CC accumulation of phosphorylated BZR1. {ECO:0000269|PubMed:28575660}.
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DR EMBL; AC004146; AAD10661.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34607.1; -; Genomic_DNA.
DR PIR; E96695; E96695.
DR RefSeq; NP_176887.1; NM_105386.1.
DR AlphaFoldDB; Q9ZW91; -.
DR STRING; 3702.AT1G67160.1; -.
DR PaxDb; Q9ZW91; -.
DR PRIDE; Q9ZW91; -.
DR ProteomicsDB; 250690; -.
DR EnsemblPlants; AT1G67160.1; AT1G67160.1; AT1G67160.
DR GeneID; 843036; -.
DR Gramene; AT1G67160.1; AT1G67160.1; AT1G67160.
DR KEGG; ath:AT1G67160; -.
DR Araport; AT1G67160; -.
DR TAIR; locus:2033676; AT1G67160.
DR eggNOG; ENOG502S0MJ; Eukaryota.
DR HOGENOM; CLU_019286_7_1_1; -.
DR InParanoid; Q9ZW91; -.
DR OrthoDB; 820958at2759; -.
DR PhylomeDB; Q9ZW91; -.
DR PRO; PR:Q9ZW91; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZW91; baseline.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IGI:TAIR.
DR GO; GO:1900459; P:positive regulation of brassinosteroid mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
DR InterPro; IPR005174; DUF295.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR Pfam; PF03478; DUF295; 1.
DR Pfam; PF00646; F-box; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 3: Inferred from homology;
KW Brassinosteroid signaling pathway; Cytoplasm; Nucleus; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..450
FT /note="F-box protein KIB3"
FT /id="PRO_0000396033"
FT DOMAIN 20..50
FT /note="F-box"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 51240 MW; E4C886D9F7AB27C2 CRC64;
MSDSDGKNME GRFEAAYIVD LVRLILERLS FVDFHRARCV SSTWYVASKS VIGVTNPTTP
WIILFPNKNV ENNGSCKLFD PHENKTYIIR DLGFDMSTSR CLASSGSWFL MFDHRADFHL
LNLFTRERIL LPSLESIDGE RYMRFKRPIS GSHIEIDKAV LWVDDKSRDY FVFCNLSSYV
AYHHKRGDDN NSWKVLQPIK HQGCVDMVFK ESKLYMISAH QCLTVFDFSG GVSPVEMECA
SFGSSVCVNR FHMKYFSNLA VTLSGEVLII VGGKMDSSPE AKCVFTVNKM DPKSSEFTVL
IKSIGDEALL LDLGITVPAK DGVMRDCIYF SNDQYHRCCG ISLRDGYNAD RICVYQIGSD
YVVQEFEHLT TSSTKLFKDA RWFFPTFGDK CCFHLWILHP VILQAKKLQK SNLKGTKPVT
REKTTIVNNV DGTTTQREKT TKGKNMIGKK
