KIB4_ARATH
ID KIB4_ARATH Reviewed; 393 AA.
AC Q9SRV0;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=F-box protein KIB4 {ECO:0000303|PubMed:28575660};
DE AltName: Full=Protein KINK SUPPRESSED IN BZR1-1D 4 {ECO:0000303|PubMed:28575660};
GN Name=KIB4 {ECO:0000303|PubMed:28575660};
GN OrderedLocusNames=At3g03730 {ECO:0000312|Araport:AT3G03730};
GN ORFNames=F20H23.24 {ECO:0000312|EMBL:AAF00644.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia, and cv. Wassilewskija;
RX PubMed=28575660; DOI=10.1016/j.molcel.2017.05.012;
RA Zhu J.-Y., Li Y., Cao D.-M., Yang H., Oh E., Bi Y., Zhu S., Wang Z.-Y.;
RT "The F-box protein KIB1 mediates brassinosteroid-induced inactivation and
RT degradation of GSK3-like kinases in Arabidopsis.";
RL Mol. Cell 66:648-657(2017).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. Required for
CC brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21
CC inactivation both by competing with substrate binding (e.g. BZR1) and
CC by promoting its ubiquitination and subsequent proteasomal degradation.
CC {ECO:0000269|PubMed:28575660}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9SU05}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9SU05}.
CC -!- DISRUPTION PHENOTYPE: Abolished brassinosteroid (BR)-induced
CC ASK7/BIN2/SK21 degradation, and BR-insensitivity. Suppression of the
CC constitutive BR-response phenotype in the dominant mutant bzr1-1D, and
CC accumulation of phosphorylated BZR1. {ECO:0000269|PubMed:28575660}.
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DR EMBL; AC009540; AAF00644.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE73979.1; -; Genomic_DNA.
DR RefSeq; NP_187023.1; NM_111244.1.
DR AlphaFoldDB; Q9SRV0; -.
DR STRING; 3702.AT3G03730.1; -.
DR PaxDb; Q9SRV0; -.
DR PRIDE; Q9SRV0; -.
DR EnsemblPlants; AT3G03730.1; AT3G03730.1; AT3G03730.
DR GeneID; 821173; -.
DR Gramene; AT3G03730.1; AT3G03730.1; AT3G03730.
DR KEGG; ath:AT3G03730; -.
DR Araport; AT3G03730; -.
DR TAIR; locus:2079399; AT3G03730.
DR eggNOG; ENOG502S0MJ; Eukaryota.
DR HOGENOM; CLU_019286_7_1_1; -.
DR InParanoid; Q9SRV0; -.
DR OMA; SCLASYN; -.
DR OrthoDB; 820958at2759; -.
DR PhylomeDB; Q9SRV0; -.
DR PRO; PR:Q9SRV0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SRV0; baseline.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IGI:TAIR.
DR GO; GO:1900459; P:positive regulation of brassinosteroid mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
DR InterPro; IPR005174; DUF295.
DR InterPro; IPR001810; F-box_dom.
DR Pfam; PF03478; DUF295; 1.
DR Pfam; PF00646; F-box; 1.
PE 3: Inferred from homology;
KW Brassinosteroid signaling pathway; Cytoplasm; Nucleus; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..393
FT /note="F-box protein KIB4"
FT /id="PRO_0000283405"
FT DOMAIN 12..59
FT /note="F-box"
FT /evidence="ECO:0000255"
SQ SEQUENCE 393 AA; 44836 MW; 39374BA6D08FCEA7 CRC64;
MSDSNKKTCN DAKQPILVLD LVRLVLERLS FVDFHRARCV SSVWYSASKS CIGGTNPTAP
WIILFPNEHV KTNNDSCKSI DPRDHSSYTI RDLGFDMVRS RCLASSGSWF LMLDHKTDFH
LLNLFTRERI PLPSLESIDG LQMKFVRTGD CGFEMSMYYK AHGLISYGKN SDLRISDAVL
WVDEKNGDYF VVWFHHSTFA YHKKGGDNNS WKVFQPSKHQ GCINMVFKEG KLYVLNPARN
ISVFDFSGGH SPVEYATPPS PNDDYYVRNL AVTLSGEVLI ISSNPKKCFV KLYKIDPKSS
EWRLIKSIGD EALILDLGIT VAAKDGVMRN CIYFSHHELL RYKGVSLCND DKYGICIYHI
KTKKKVQEFE HLTTSSPILF KDARWFFPTF GGN
