KIBRA_DROER
ID KIBRA_DROER Reviewed; 1283 AA.
AC B3P3M8;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Protein kibra;
GN Name=Kibra; ORFNames=GG21121;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a
CC signaling pathway that plays a pivotal role in organ size control and
CC tumor suppression by restricting proliferation and promoting apoptosis.
CC The core of this pathway is composed of a kinase cascade wherein Hippo
CC (Hpo), in complex with its regulatory protein Salvador (Sav),
CC phosphorylates and activates Warts (Wts) in complex with its regulatory
CC protein Mats, which in turn phosphorylates and inactivates the Yorkie
CC (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to
CC regulate the Hippo signaling pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms a complex with Mer and Ex. Interacts (via domain WW 1)
CC with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and Wts (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Apical cell membrane
CC {ECO:0000250}. Note=Localizes at the apical cortex of epithelial cells
CC and cytoplasmic, punctate. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WWC family. KIBRA subfamily. {ECO:0000305}.
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DR EMBL; CH954181; EDV48916.1; -; Genomic_DNA.
DR RefSeq; XP_001979958.1; XM_001979922.2.
DR AlphaFoldDB; B3P3M8; -.
DR SMR; B3P3M8; -.
DR STRING; 7220.FBpp0139667; -.
DR EnsemblMetazoa; FBtr0141175; FBpp0139667; FBgn0113304.
DR GeneID; 6552773; -.
DR KEGG; der:6552773; -.
DR eggNOG; KOG0940; Eukaryota.
DR eggNOG; KOG3209; Eukaryota.
DR HOGENOM; CLU_005420_1_0_1; -.
DR OMA; HHTHIPR; -.
DR OrthoDB; 364990at2759; -.
DR PhylomeDB; B3P3M8; -.
DR ChiTaRS; kibra; fly.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0106037; C:apicomedial cortex; IEA:EnsemblMetazoa.
DR GO; GO:0005911; C:cell-cell junction; IEA:EnsemblMetazoa.
DR GO; GO:0098592; C:cytoplasmic side of apical plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0036375; C:Kibra-Ex-Mer complex; IEA:EnsemblMetazoa.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0060253; P:negative regulation of glial cell proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0046621; P:negative regulation of organ growth; IEA:EnsemblMetazoa.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:EnsemblMetazoa.
DR GO; GO:0035332; P:positive regulation of hippo signaling; ISS:UniProtKB.
DR GO; GO:0045463; P:R8 cell development; IEA:EnsemblMetazoa.
DR GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:EnsemblMetazoa.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; SSF49562; 1.
DR SUPFAM; SSF51045; SSF51045; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 3: Inferred from homology;
KW Cell membrane; Coiled coil; Cytoplasm; Membrane; Phosphoprotein; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..1283
FT /note="Protein kibra"
FT /id="PRO_0000392970"
FT DOMAIN 53..86
FT /note="WW 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 100..133
FT /note="WW 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 690..810
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 200..228
FT /evidence="ECO:0000255"
FT COILED 334..462
FT /evidence="ECO:0000255"
FT COILED 1048..1075
FT /evidence="ECO:0000255"
FT COMPBIAS 31..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..910
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1283 AA; 143670 MW; A2128BC76FC54E37 CRC64;
MPNLQQTASQ SQHHLYPPHL RPHHHHQQQQ HHQQQQQQQH THHQQQQQHH SDFPLPDGWD
IAKDFDGKTY YIDHINKKTT WLDPRDCYTK PQTFEDCVGD ELPMGWEESY DPNIGPYYIN
HLAQSTQLED PRQEWKTVQE QMLSDYLSAA QDQLENKREM LDVKQQRLLW AQEEYNHLKL
AASRSSLCSS SSSMSRHDPE LLRADLMLAR ERVHQLKQEL THITNDISYT ERGMNTLYSV
GEKINARENG CYDIAEVQAI REEMLKVHKS LVSGEKVREE LMRSLVQIKN ELGRQQISEE
NSDLASPFDR VCVASQTDLC GSSGDNLNGG ARFAEMAKTK LQYAEWRKHI KKLQQQLADH
VERIEPGQLE SDKDRILLIQ EKEKLLNDLN SISLKSRSEE EKRVIHQTRH KLEEDLKEAY
EANNTCVANR LRFHEEKQLL LDKLQEALKS TKLLEERLKS FSSESTFSIS SGSSLGSLST
ASSKSALSFT DIYIDPFAVD SPIDVVDLRR RSQRLFQQHQ QQRLLPVHPV LQQQQSAEVT
LSPRSSLSME TPPASPMKYN AGADQTPQAL KEEPTYANAL PAPPAYTAPP PVPISGVRAR
PYDLDSTVLD CMMLEAKLQK LNMGTPLNLA AAPLSPISEK PSLLDLPQEM LSRSSSTSNT
RSVSAAVSNE SVAGDSGVFE ASRAHLPRKE LAQVQIGLKY LKQEGVLVVS LERANNLLAL
WTASADNSQV YLRAALLPNS LTSIRTKALG DFQKPFFNDT FAVPITLDKL LTKSLQVTVV
TMTGQKEEII GTVQISMAEF NPEDSTLKWY NVLSSKFIPS FESLDIPSTS AAAAAAAVAA
SNAPSSGNNR EESSDESTIT SSQTSTLTRN QAPCMELQEQ ITAELLELGP LNEPECSDDD
DEDEEEELDD KQLVSDVGLM NSSGMLDAYL QNMKQEFADK ETNTDRAYLP EKSRGQSQLM
DDRPVKRSQT FTPSAAVSKN RYNCRLNRSD SDSAMHCGVA PHTFQRGAAE RRSLRFHTKA
PKSVTKLHHT HIPRTSLDLE LDLQAQHSKL YFLNDQIAKL QNLKEVLQKA CENKDPLVAA
WAIENEEFQR LVARADPAKC PEERQLQKLL MKTAKEIHKL RKTKVPKGCP DLVSFKEKIT
FFTRKGLSVP ELPSEFTLPE ANPIEEEEEE EDEDEFYNSP ETAIAINTAL VASSNRNKNL
SEHPHRSTSG AVPKLPAPVA TPAATPAATP AATPVATPAA TPVVATAAQP EAKPAAAPIP
VASNDAEQQR FDYVVDRNYG VEV
