ID   KIBRA_XENTR             Reviewed;        1108 AA.
AC   A4IIJ3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein KIBRA;
DE   AltName: Full=WW domain-containing protein 1;
GN   Name=wwc1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the regulation of the Hippo signaling
CC       pathway. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The C2-domain mediates homodimerization. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WWC family. KIBRA subfamily. {ECO:0000305}.
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DR   EMBL; BC136041; AAI36042.1; -; mRNA.
DR   RefSeq; NP_001096212.1; NM_001102742.1.
DR   AlphaFoldDB; A4IIJ3; -.
DR   SMR; A4IIJ3; -.
DR   STRING; 8364.ENSXETP00000035914; -.
DR   PRIDE; A4IIJ3; -.
DR   DNASU; 100124763; -.
DR   GeneID; 100124763; -.
DR   KEGG; xtr:100124763; -.
DR   CTD; 23286; -.
DR   Xenbase; XB-GENE-985007; wwc1.
DR   eggNOG; KOG3209; Eukaryota.
DR   InParanoid; A4IIJ3; -.
DR   OrthoDB; 364990at2759; -.
DR   Reactome; R-XTR-2028269; Signaling by Hippo.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019900; F:kinase binding; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0046621; P:negative regulation of organ growth; IBA:GO_Central.
DR   GO; GO:0035330; P:regulation of hippo signaling; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd08680; C2_Kibra; 1.
DR   CDD; cd00201; WW; 2.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037771; C2_WWC.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00397; WW; 2.
DR   SMART; SM00456; WW; 2.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF51045; SSF51045; 2.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1108
FT                   /note="Protein KIBRA"
FT                   /id="PRO_0000309489"
FT   DOMAIN          6..39
FT                   /note="WW 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT   DOMAIN          53..86
FT                   /note="WW 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT   DOMAIN          653..776
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          434..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          828..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          111..247
FT                   /evidence="ECO:0000255"
FT   COILED          294..329
FT                   /evidence="ECO:0000255"
FT   COILED          360..434
FT                   /evidence="ECO:0000255"
FT   COILED          998..1065
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        523..546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        835..849
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1108 AA;  125267 MW;  1B3994E1332E2AE1 CRC64;
     MIRKELPLPE GWEEARDVDG KVYYIDHTSK TTSWIDPRDR FTKPLTFADC IGDELPLGWE
     ESYDTQVGVY YIDHNSQTTQ IEDPRVQWRR EQERMLKDYL VLAQEALLAQ KEIYQVKQQR
     LELAQKEYRT LNDVWKHKVG SQTSLVSGSS SSSKYDPDIL KAEIATTKSR VNKLKREMVF
     LRQELQYKEN GYQTLKEIDL KMSKNHCAYK LDEAQAILNE MKTIKKAITS GEREKQDLIQ
     SLAELKNGFL VDKGSQSDLW ASNTSLASSA NSLSRQYLNV SSQTDISGNL SVVSNNHLAE
     KVRLQLRYEE AKRRIANIKI QLAKIDSDAW PGVLDSERDR LILISEKEEL LKEMRFISPR
     KWSQSEVERL ESEKKQLEED LQAARDTQSK ALTERLKMSS KRNQLVKELE ETTRLIASLQ
     AQLKCLSTSM QSLSSGSSPG SLASSRGSLV TSSQDSSTSA SVSDLYYEQL DHLDSEYQNK
     VDFLIQEGAM GYRPSGCITT IHENEVVRSQ KTDPANRVKA LRSLSGTPKS MTSLSPRSSL
     SSPSPPCSPL VTDPLLTVDA FLSQIDFEDI DLPLSFTELN VNAGGDSYQH ETDEEPSGQG
     LSCLGVSSLS VAGVSAAVSD ESVTGDSGVY EATNQRTLME NAVFDGEDSE MMDTAKIKIG
     MKYDEKNKHF AVFVIQLDNL AALLLHQNEK LYIRVAVLPC SESTSCLFRT RTLEQSDTLL
     YNEMFLVSTS HSALRQKTLR VDVCTRQSNH HEECLGGSQI SLADVCHSEE QEAHWYNLLS
     YRYLKRQSKT SKQKISCCEE SGIENPDSVS ALLKQTAAEL EAVRKQIGES TDPPEYIWPE
     KKDNVPDEDG ISENEGEEEF DGDVQCETEE SDMQAATDSA SVKVDKETNT EGLAMSLSSV
     RPKDKRAATP MQAPFIRGNT IIRSKTFSPG PQSQYICRLN RSDSESSTLS KKPPFVRNAM
     ERRSVRVKRP SVKSTGSERL IRTSLDLELD LQASRTWHHQ LTQEISVLRE LKEQLEQAKR
     LGENELPQRV KDDETFKVML RQVEKQVQKI EQKYEMQADK MMRAAAKDVH RLRGQSSKEP
     LEVQSFREKM AFFTRPRMNL PTLTADDV