KICS2_DANRE
ID KICS2_DANRE Reviewed; 449 AA.
AC Q1L8F9; Q1JQ61; Q5RIG9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=KICSTOR subunit 2 {ECO:0000305};
GN Name=kics2; ORFNames=si:ch211-125a15.1, zgc:136251;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As part of the KICSTOR complex may function in the amino
CC acid-sensing branch of the TORC1 signaling pathway.
CC {ECO:0000250|UniProtKB:Q96MD2}.
CC -!- SUBUNIT: May be part of the KICSTOR complex.
CC {ECO:0000250|UniProtKB:Q96MD2}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96MD2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1L8F9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1L8F9-2; Sequence=VSP_034841;
CC -!- SIMILARITY: Belongs to the KICS2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI16473.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BX255922; CAI11582.2; -; Genomic_DNA.
DR EMBL; CR790375; CAK04780.1; -; Genomic_DNA.
DR EMBL; BC116472; AAI16473.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001025261.3; NM_001030090.3. [Q1L8F9-1]
DR AlphaFoldDB; Q1L8F9; -.
DR SMR; Q1L8F9; -.
DR STRING; 7955.ENSDARP00000117810; -.
DR PaxDb; Q1L8F9; -.
DR Ensembl; ENSDART00000148155; ENSDARP00000117810; ENSDARG00000045790. [Q1L8F9-1]
DR GeneID; 555715; -.
DR KEGG; dre:555715; -.
DR CTD; 144577; -.
DR ZFIN; ZDB-GENE-041210-104; kics2.
DR eggNOG; ENOG502QTBE; Eukaryota.
DR GeneTree; ENSGT00390000009583; -.
DR HOGENOM; CLU_050627_0_0_1; -.
DR InParanoid; Q1L8F9; -.
DR OMA; PQKFINA; -.
DR PhylomeDB; Q1L8F9; -.
DR TreeFam; TF329125; -.
DR Reactome; R-DRE-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q1L8F9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000045790; Expressed in mature ovarian follicle and 21 other tissues.
DR ExpressionAtlas; Q1L8F9; baseline and differential.
DR GO; GO:0140007; C:KICSTOR complex; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034198; P:cellular response to amino acid starvation; ISS:UniProtKB.
DR GO; GO:0042149; P:cellular response to glucose starvation; ISS:UniProtKB.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; ISS:UniProtKB.
DR GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR Gene3D; 1.10.3450.30; -; 1.
DR InterPro; IPR038060; C12orf66-like_central_sf.
DR InterPro; IPR018544; KICS_2.
DR PANTHER; PTHR31581; PTHR31581; 1.
DR Pfam; PF09404; C12orf66_like; 1.
DR SUPFAM; SSF158548; SSF158548; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Lysosome; Membrane; Reference proteome.
FT CHAIN 1..449
FT /note="KICSTOR subunit 2"
FT /id="PRO_0000321904"
FT VAR_SEQ 153..187
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_034841"
FT CONFLICT 14
FT /note="P -> S (in Ref. 1; CAK04780)"
FT /evidence="ECO:0000305"
FT CONFLICT 438
FT /note="K -> E (in Ref. 2; AAI16473)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 51167 MW; 661463986B0E587F CRC64;
MCDPQRDEEL RPVPKERAVL ESFFTQLGMF WFDRAKDYVE KEKDASKSAG AIWGSLLAAL
AHLAAAEKAY HNMTFLGQKL GGQSFFSRKD SIRTIYTSLH NELKKVVSMG RHAPGGSTPN
LEELLPHLSE QLCHFTQARM EIADFYEKMH TLGSQKTVNS EELVGALDSI LQKYSSRFHH
PILSRLESSF QVEVDVLTQL LRCQAQISEW HFLPSLLNLH GAHSKLQAWG QVFERQRETR
KHLFGGQSQK AVQPPHLFLW LQRLQATLLA KFSFYFHEAL SRQTSQSEMK TLTARTSLDY
FGKISGFIRK YDASNVSLVF DNRGSESFQG HGYHHPQSYR EAPKGVDQFP AVVSLPGGER
PVTHWPNVIM IMSDRSTELN TLDKVVHFYD DKVQSTYFLA RPEPHFTIVV IFDGRKSERD
SYIVAFLQEL IGSLRNSKPF TSLKPGSKG
