ID   KICS2_XENLA             Reviewed;         442 AA.
AC   Q6IR80;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=KICSTOR subunit 2;
GN   Name=kics2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the KICSTOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q96MD2}.
CC   -!- SUBUNIT: May be part of the KICSTOR complex.
CC       {ECO:0000250|UniProtKB:Q96MD2}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96MD2}.
CC   -!- SIMILARITY: Belongs to the KICS2 family. {ECO:0000305}.
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DR   EMBL; BC071020; AAH71020.1; -; mRNA.
DR   RefSeq; NP_001085035.1; NM_001091566.1.
DR   AlphaFoldDB; Q6IR80; -.
DR   SMR; Q6IR80; -.
DR   DNASU; 432102; -.
DR   GeneID; 432102; -.
DR   KEGG; xla:432102; -.
DR   CTD; 432102; -.
DR   Xenbase; XB-GENE-959001; kics2.L.
DR   OrthoDB; 365605at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 432102; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0140007; C:KICSTOR complex; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; ISS:UniProtKB.
DR   GO; GO:0042149; P:cellular response to glucose starvation; ISS:UniProtKB.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   Gene3D; 1.10.3450.30; -; 1.
DR   InterPro; IPR038060; C12orf66-like_central_sf.
DR   InterPro; IPR018544; KICS_2.
DR   PANTHER; PTHR31581; PTHR31581; 1.
DR   Pfam; PF09404; C12orf66_like; 1.
DR   SUPFAM; SSF158548; SSF158548; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..442
FT                   /note="KICSTOR subunit 2"
FT                   /id="PRO_0000321905"
SQ   SEQUENCE   442 AA;  50525 MW;  EE5C89D8E526D057 CRC64;
     MIPPTSAQVT AEQNVLQTFF SHLGNFSYDK AKDHVEKEKE GNKSAGASWS LMLAALAHLA
     AAQKAYHSMS FLGQKQGGQL FFSRKDSIRT NYTSLYNELK KVVTTGRNAV GGTAPHLEEL
     LSHLSEQLCY FVQAHMEIAD FYEKMYTLSS QKFINAEELV KILEAILKKY SSRFHHPTLS
     PLESGFQLEV DVLAHLLKAQ FLIYEWKFLP ALVNLHNAHT KLQTWGQIFE KQKETKKHLF
     GGQSQKVAQP PHLFLWLMKF KNLLLAKFSF YFHEALSRQT SEMKTLTAKT NPDYFGKISS
     FIRKYDAVNV SLIYDTRGSE NFQGHGYHHP DSYREAPKGM DQYPAVVSLP NDRPIMHWPN
     VIMIMTDKSA DLNTLEKVVH FYDDKVQSTY FLTRPEPNFT IVVIFESKKS ERDSHFTSFL
     NELSQSLKGS RAFASLKPGS KV