ID   KIF11_DICDI             Reviewed;         685 AA.
AC   Q6S001; Q54FA2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Kinesin-related protein 11;
DE   AltName: Full=Kinesin family member 11;
DE   AltName: Full=Kinesin-7;
GN   Name=kif11; ORFNames=DDB_G0291039;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, AND NOMENCLATURE.
RC   STRAIN=AX4;
RX   PubMed=14641909; DOI=10.1186/1471-2164-4-47;
RA   Kollmar M., Gloeckner G.;
RT   "Identification and phylogenetic analysis of Dictyostelium discoideum
RT   kinesin proteins.";
RL   BMC Genomics 4:47-47(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Microtubule-associated force-producing protein that plays a
CC       role in organelle transport. Its motor activity is directed toward the
CC       microtubule's plus end (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR   EMBL; AY484464; AAR39440.1; -; Genomic_DNA.
DR   EMBL; AAFI02000174; EAL61950.1; -; Genomic_DNA.
DR   RefSeq; XP_635435.1; XM_630343.1.
DR   AlphaFoldDB; Q6S001; -.
DR   SMR; Q6S001; -.
DR   STRING; 44689.DDB0201556; -.
DR   PaxDb; Q6S001; -.
DR   EnsemblProtists; EAL61950; EAL61950; DDB_G0291039.
DR   GeneID; 8627935; -.
DR   KEGG; ddi:DDB_G0291039; -.
DR   dictyBase; DDB_G0291039; kif11.
DR   eggNOG; KOG0242; Eukaryota.
DR   HOGENOM; CLU_001485_24_1_1; -.
DR   InParanoid; Q6S001; -.
DR   OMA; NNFEESH; -.
DR   PhylomeDB; Q6S001; -.
DR   PRO; PR:Q6S001; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0035371; C:microtubule plus-end; IDA:dictyBase.
DR   GO; GO:0005876; C:spindle microtubule; IDA:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IDA:dictyBase.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; Microtubule;
KW   Motor protein; Nucleotide-binding; Reference proteome; Transport.
FT   CHAIN           1..685
FT                   /note="Kinesin-related protein 11"
FT                   /id="PRO_0000365586"
FT   DOMAIN          4..405
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   REGION          36..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          411..488
FT                   /evidence="ECO:0000255"
FT   COILED          574..683
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        49..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         156..163
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   685 AA;  75439 MW;  F915440ED42B3967 CRC64;
     MNENISVSVR ARPFNEKEVK DKEHCLWQFG NNNTITSLPP PITQPVSSLP PISTPIKSSS
     SSSTSTSAGS LKTPLKTPLK TPLKTPLKTN STTTNTTVPA SPAPTSSLTS KFVSNSYTYD
     HLFPPTCDNY EVYDTVAREL VKSAMEGYNA SIMAYGITSS GKTFTMTGSG KKNPGIIPLS
     IQDIFTYIQE CKEREFLLRV SYLEIYNETV NDLLGVNQEN FNLKIHEHPV TGVYVAGLKE
     EIVLSVEHVL SLISAGEAHR HVGSTSYNLQ SSRSHTIFKM IIESKEVLPE GSGSGGLESP
     VRYSTLNLID LAGSEKASES TISAIRNKEG SYINKSLLTL GTVISKLSEK DTGYIPYRDS
     KLTRVLQNSL SGNSRVAIIC TITLASNNFE ESHNTLKFAS RAKKISNNAK VNEILDDKAL
     LKQYRNEIAE LKSKLSDALS TEKELQETLT EKEKMKITNQ ELLHKLVDAE KHRSLLESKI
     NNLNKLILVS TSVNNSASKG GSGSGNGNGS RSTFVSPSQN SHHHHGDLGS ITPNSFSNLL
     LQSPSQNNNN NSHISPLSQS TSSLTIGGGS GNGFESNELI QIQSKMAKLE LELEEKNKKI
     DFLTSFNQDS ALEKIKQLEG ELVQRDMDLG LYQRESTRLQ TLLSHKDEKI SSLESKLRDI
     LLKFKQIDSE NTSLKSKIQE YEVMY